Results 11 to 20 of about 3,311,882 (262)

Is HIV short-sighted? Insights from a multistrain nested model [PDF]

, 2013
An important component of pathogen evolution at the population level is evolution within hosts. Unless evolution within hosts is very slow compared to the duration of infection, the composition of pathogen genotypes within a host is likely to change ...
Lythgoe, KA, Pellis, Lorenzo; id_orcid, Lythgoe, Katrina A, Lythgoe, Katrina A., Pellis, L, Lythgoe, Katrina Abigail, Pellis, Lorenzo, Fraser, C, Fraser, Christophe   +8 more
core   +1 more source

Evolution is Viral: The Theory of Collective Discontinuous Evolution [PDF]

, 2010
Herein will be discussed the problems associated with the origin of species according to Darwinist processes of individual mutations. We will argue that individual mutations cannot be the driving force of species origination.
Iosif M. Gershteyn, Mikhail L. Gershteyn, Mikhail L. Gershteyn, Iosif Gershteyn   +3 more
core   +1 more source

Viral dynamics during structured treatment interruptions of chronic human immunodeficiency virus type 1 infection [PDF]

, 2002
Although antiviral agents which block human immunodeficiency virus (HIV) replication can result in long-term suppression of viral loads to undetectable levels in plasma, long-term therapy fails to eradicate virus, which generally rebounds after a single ...
Ruiz, L, Javier Martinez-Picado, Clotet, B, Frost, SDW, Martinez-Picado, J, Lidia Ruiz, Leigh Brown, AJ, Simon D. W. Frost, Bonaventura Clotet, Andrew J. Leigh Brown   +9 more
core   +1 more source

Lethal Synergism of 2009 Pandemic H1N1 Influenza Virus and Streptococcus pneumoniae Coinfection Is Associated with Loss of Murine Lung Repair Responses

mBio, 2011
Secondary bacterial infections increase disease severity of influenza virus infections and contribute greatly to increased morbidity and mortality during pandemics.
John C. Kash, Kathie-Anne Walters, A. Sally Davis, Aline Sandouk, Louis M. Schwartzman, Brett W. Jagger, Daniel S. Chertow, Li Qi, Rolf E. Kuestner, Adrian Ozinsky, Jeffery K. Taubenberger   +10 more
doaj   +1 more source

Alvira : comparative genomics of viral strains [PDF]

, 2007
The Alvira tool is a general purpose multiple sequence alignment viewer with a special emphasis on the comparative analysis of viral genomes. This new tool has been devised specifically to address the problem of the simultaneous analysis of a large ...
Fremez, Romain, Faraut, Thomas, Thomas Faraut, Romain Fremez, Eric Baranowski, François Enault, Baranowski, Eric, Enault, François   +7 more
core   +1 more source

Identification of CX3CR1+ mononuclear phagocyte subsets involved in HIV-1 and SIV colorectal transmission

iScience, 2022
Summary: The difficulty to unambiguously identify the various subsets of mononuclear phagocytes (MNPs) of the intestinal lamina propria has hindered our understanding of the initial events occurring after mucosal exposure to HIV-1.Here, we compared the ...
Mariangela Cavarelli, Chiara Foglieni, Naima Hantour, Tilo Schorn, Antonello Ferrazzano, Stefania Dispinseri, Delphine Desjardins, Ugo Elmore, Nathalie Dereuddre-Bosquet, Gabriella Scarlatti, Roger Le Grand   +10 more
doaj   +1 more source

454-Pyrosequencing: A Molecular Battiscope for Freshwater Viral Ecology [PDF]

, 2010
Viruses, the most abundant biological entities on the planet, are capable of infecting organisms from all three branches of life, although the majority infect bacteria where the greatest degree of cellular diversity lies.
Allison, Heather E, Woodward, Martin J, Rooks, David, Rooks, D. J., Smith, Darren L, McCarthy, Alan J, McDonald, James E; id_orcid, Woodward, Martin J., Darren L. Smith, Smith, Darren, Rooks, David J, David J. Rooks, Martin J. Woodward, McCarthy, Alan, McCarthy, A. J., Smith, D. L., Heather E. Allison, McDonald, James, Allison, Heather, James E. McDonald, Woodward, Martin, Alan J. McCarthy, McDonald, J. E., Allison, H. E.   +23 more
core   +1 more source

Evaluation of Preexisting Anti-Hemagglutinin Stalk Antibody as a Correlate of Protection in a Healthy Volunteer Challenge with Influenza A/H1N1pdm Virus

mBio, 2018
Influenza virus hemagglutinin (HA) surface glycoprotein is currently the primary target of licensed influenza vaccines. Recently, broadly reactive antibodies that target the stalk region of the HA have become a major focus of current novel vaccine ...
Jae-Keun Park, Alison Han, Lindsay Czajkowski, Susan Reed, Rani Athota, Tyler Bristol, Luz Angela Rosas, Adriana Cervantes-Medina, Jeffery K. Taubenberger, Matthew J. Memoli   +9 more
doaj   +1 more source

Phylogeographic analysis reveals an ancient East African origin of human herpes simplex virus 2 dispersal out-of-Africa

Nature Communications, 2022
There are competing hypotheses for human herpes simplex virus 2’s migration out-of-Africa. Here, the authors sequence 65 new herpes simplex virus 2 genomes with a focus on under-sampled sub-Saharan African countries, suggesting an Eastern African origin ...
Jennifer L. Havens, Sébastien Calvignac-Spencer, Kevin Merkel, Sonia Burrel, David Boutolleau, Joel O. Wertheim   +5 more
doaj   +1 more source

Contemporary Avian Influenza A Virus Subtype H1, H6, H7, H10, and H15 Hemagglutinin Genes Encode a Mammalian Virulence Factor Similar to the 1918 Pandemic Virus H1 Hemagglutinin

mBio, 2014
Zoonotic avian influenza virus infections may lead to epidemics or pandemics. The 1918 pandemic influenza virus has an avian influenza virus-like genome, and its H1 hemagglutinin was identified as a key mammalian virulence factor.
Li Qi, Lindsey M. Pujanauski, A. Sally Davis, Louis M. Schwartzman, Daniel S. Chertow, David Baxter, Kelsey Scherler, Kevan L. Hartshorn, Richard D. Slemons, Kathie-Anne Walters, John C. Kash, Jeffery K. Taubenberger   +11 more
doaj   +1 more source