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Viral evolution and epidemiology [PDF]

Current Opinion in Infectious Diseases, 1997
This review highlights recent research on viral evolution and its use towards understanding disease pathogenesis and epidemiology. The development of techniques such as enzymatic amplification of viral genomes and automated sequencing has led to a dramatic increase in the amount of sequence information from clinical samples. These sequences (RNA or DNA,
Katrin, Leitmeyer, Rebeca, Rico-Hesse
openaire   +2 more sources

Intradermal needle-free injection prevents African Swine Fever transmission, while intramuscular needle injection does not

Scientific Reports, 2023
Shared needles are a possible iatrogenic and hematogenous inanimate vector of African Swine Fever virus (ASFV) in farm conditions. To evaluate that possible transmission, sixty, 4-week-old pigs were procured from an ASF free herd free. Upon arrival, pigs
Muhammad Salman, Hongyao Lin, Roypim Suntisukwattana, Parin Watcharavongtip, Patumporn Jermsutjarit, Angkana Tantituvanont, Dachrit Nilubol   +6 more
doaj   +1 more source

Topology of viral evolution [PDF]

Proceedings of the National Academy of Sciences, 2013
SignificanceEvolution is mediated not only by random mutations over a number of generations (vertical evolution), but also through the mixture of genomic material between individuals of different lineages (horizontal evolution). The standard evolutionary representation, the phylogenetic tree, faithfully represents the former but not the latter scenario.
Chan, Joseph Minhow, Carlsson, Gunnar, Rabadan, Raul   +2 more
openaire   +3 more sources

Computationally designed proteins mimic antibody immune evasion in viral evolution [PDF]

Immunity
Jeremy Luban, Michael S Seaman, Debora S Marks   +2 more
exaly   +2 more sources

Continuous HIV-1 Escape from Autologous Neutralization and Development of Cross-Reactive Antibody Responses Characterizes Slow Disease Progression of Children

Vaccines, 2021
The antibodies with different effector functions evoked by Human Immunodeficiency Virus type 1 (HIV-1) transmitted from mother to child, and their role in the pathogenesis of infected children remain unresolved. So, too, the kinetics and breadth of these
Stefania Dispinseri, Mariangela Cavarelli, Monica Tolazzi, Anna Maria Plebani, Marianne Jansson, Gabriella Scarlatti   +5 more
doaj   +1 more source

Intranasal delivery of inactivated PRRSV loaded cationic nanoparticles coupled with enterotoxin subunit B induces PRRSV-specific immune responses in pigs

Scientific Reports, 2022
This study was conducted to evaluate the induction of systemic and mucosal immune responses and protective efficacy following the intranasal administration of inactivated porcine reproductive and respiratory syndrome virus (PRRSV) loaded in polylactic ...
Puwich Chaikhumwang, Adthakorn Madapong, Kepalee Saeng-chuto, Dachrit Nilubol, Angkana Tantituvanont   +4 more
doaj   +1 more source

Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival

Nature Communications, 2021
Antibody responses are critical for protection from developing severe COVID-19 following SARS-CoV-2 infection. Here the authors show that antibody responses against SARS-CoV-2 spike protein correlate with neutralizing capacity and protection, are not ...
Stefania Dispinseri, Massimiliano Secchi, Maria Franca Pirillo, Monica Tolazzi, Martina Borghi, Cristina Brigatti, Maria Laura De Angelis, Marco Baratella, Elena Bazzigaluppi, Giulietta Venturi, Francesca Sironi, Andrea Canitano, Ilaria Marzinotto, Cristina Tresoldi, Fabio Ciceri, Lorenzo Piemonti, Donatella Negri, Andrea Cara, Vito Lampasona, Gabriella Scarlatti   +19 more
doaj   +1 more source

Is HIV short-sighted? Insights from a multistrain nested model [PDF]

, 2013
An important component of pathogen evolution at the population level is evolution within hosts. Unless evolution within hosts is very slow compared to the duration of infection, the composition of pathogen genotypes within a host is likely to change ...
Lythgoe, KA, Pellis, Lorenzo; id_orcid, Lythgoe, Katrina A, Lythgoe, Katrina A., Pellis, L, Lythgoe, Katrina Abigail, Pellis, Lorenzo, Fraser, C, Fraser, Christophe   +8 more
core   +1 more source

Co-infection of porcine deltacoronavirus and porcine epidemic diarrhea virus induces early TRAF6-mediated NF-κB and IRF7 signaling pathways through TLRs

Scientific Reports, 2022
Porcine deltacoronavirus (PDCoV) and porcine epidemic diarrhea virus (PEDV) infect the small intestine and cause swine enteric coronavirus disease. The mucosal innate immune system is the first line of defense against viral infection.
Kepalee Saeng-chuto, Adthakorn Madapong, Kampon Kaeoket, Pablo Enrique Piñeyro, Angkana Tantituvanont, Dachrit Nilubol   +5 more
doaj   +1 more source

The PB2-E627K Mutation Attenuates Viruses Containing the 2009 H1N1 Influenza Pandemic Polymerase

mBio, 2010
The swine-origin H1N1 influenza A virus emerged in early 2009 and caused the first influenza pandemic in 41 years. The virus has spread efficiently to both the Northern and the Southern Hemispheres and has been associated with over 16,000 deaths.
Brett W. Jagger, Matthew J. Memoli, Zong-Mei Sheng, Li Qi, Rachel J. Hrabal, Genevieve L. Allen, Vivien G. Dugan, Ruixue Wang, Paul Digard, John C. Kash, Jeffery K. Taubenberger   +10 more
doaj   +1 more source