Results 11 to 20 of about 220,643 (261)

Continuous HIV-1 Escape from Autologous Neutralization and Development of Cross-Reactive Antibody Responses Characterizes Slow Disease Progression of Children

Vaccines, 2021
The antibodies with different effector functions evoked by Human Immunodeficiency Virus type 1 (HIV-1) transmitted from mother to child, and their role in the pathogenesis of infected children remain unresolved. So, too, the kinetics and breadth of these
Stefania Dispinseri, Mariangela Cavarelli, Monica Tolazzi, Anna Maria Plebani, Marianne Jansson, Gabriella Scarlatti   +5 more
doaj   +1 more source

Intranasal delivery of inactivated PRRSV loaded cationic nanoparticles coupled with enterotoxin subunit B induces PRRSV-specific immune responses in pigs

Scientific Reports, 2022
This study was conducted to evaluate the induction of systemic and mucosal immune responses and protective efficacy following the intranasal administration of inactivated porcine reproductive and respiratory syndrome virus (PRRSV) loaded in polylactic ...
Puwich Chaikhumwang, Adthakorn Madapong, Kepalee Saeng-chuto, Dachrit Nilubol, Angkana Tantituvanont   +4 more
doaj   +1 more source

Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival

Nature Communications, 2021
Antibody responses are critical for protection from developing severe COVID-19 following SARS-CoV-2 infection. Here the authors show that antibody responses against SARS-CoV-2 spike protein correlate with neutralizing capacity and protection, are not ...
Stefania Dispinseri, Massimiliano Secchi, Maria Franca Pirillo, Monica Tolazzi, Martina Borghi, Cristina Brigatti, Maria Laura De Angelis, Marco Baratella, Elena Bazzigaluppi, Giulietta Venturi, Francesca Sironi, Andrea Canitano, Ilaria Marzinotto, Cristina Tresoldi, Fabio Ciceri, Lorenzo Piemonti, Donatella Negri, Andrea Cara, Vito Lampasona, Gabriella Scarlatti   +19 more
doaj   +1 more source

The PB2-E627K Mutation Attenuates Viruses Containing the 2009 H1N1 Influenza Pandemic Polymerase

mBio, 2010
The swine-origin H1N1 influenza A virus emerged in early 2009 and caused the first influenza pandemic in 41 years. The virus has spread efficiently to both the Northern and the Southern Hemispheres and has been associated with over 16,000 deaths.
Brett W. Jagger, Matthew J. Memoli, Zong-Mei Sheng, Li Qi, Rachel J. Hrabal, Genevieve L. Allen, Vivien G. Dugan, Ruixue Wang, Paul Digard, John C. Kash, Jeffery K. Taubenberger   +10 more
doaj   +1 more source

Co-infection of porcine deltacoronavirus and porcine epidemic diarrhea virus induces early TRAF6-mediated NF-κB and IRF7 signaling pathways through TLRs

Scientific Reports, 2022
Porcine deltacoronavirus (PDCoV) and porcine epidemic diarrhea virus (PEDV) infect the small intestine and cause swine enteric coronavirus disease. The mucosal innate immune system is the first line of defense against viral infection.
Kepalee Saeng-chuto, Adthakorn Madapong, Kampon Kaeoket, Pablo Enrique Piñeyro, Angkana Tantituvanont, Dachrit Nilubol   +5 more
doaj   +1 more source

Modelling the evolution of viral oncogenesis [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2019
Most human oncogenic viruses share several characteristics, such as being DNA viruses, having long (co)evolutionary histories with their hosts and causing either latent or chronic infections. They can reach high prevalences while causing relatively low case mortality, which makes them quite fit according to virulence evolution theory.
Murall, Carmen Lia, Alizon, Samuel
openaire   +2 more sources

R5 HIV‐1 envelope attracts dendritic cells to cross the human intestinal epithelium and sample luminal virions via engagement of the CCR5

EMBO Molecular Medicine, 2013
The gastrointestinal tract is a principal route of entry and site of persistence of human immunodeficiency virus type 1 (HIV‐1). The intestinal mucosa, being rich of cells that are the main target of the virus, represents a primary site of viral ...
Mariangela Cavarelli, Chiara Foglieni, Maria Rescigno, Gabriella Scarlatti   +3 more
doaj   +1 more source

An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus

mBio, 2015
Influenza virus infections are a global public health problem, with a significant impact of morbidity and mortality from both annual epidemics and pandemics.
Louis M. Schwartzman, Andrea L. Cathcart, Lindsey M. Pujanauski, Li Qi, John C. Kash, Jeffery K. Taubenberger   +5 more
doaj   +1 more source

Evolution of Viral Structure

Theoretical Population Biology, 2002
Viruses vastly outnumber their host cells and must present a huge selective pressure. It is also becoming evident that only a small percent of the eukaryotic genome codes for molecules involved in cellular structures and functions, and that much of the remainder may have a viral origin.
Bamford, D, Burnett, R, Stuart, D
openaire   +3 more sources

Lethal Synergism of 2009 Pandemic H1N1 Influenza Virus and Streptococcus pneumoniae Coinfection Is Associated with Loss of Murine Lung Repair Responses

mBio, 2011
Secondary bacterial infections increase disease severity of influenza virus infections and contribute greatly to increased morbidity and mortality during pandemics.
John C. Kash, Kathie-Anne Walters, A. Sally Davis, Aline Sandouk, Louis M. Schwartzman, Brett W. Jagger, Daniel S. Chertow, Li Qi, Rolf E. Kuestner, Adrian Ozinsky, Jeffery K. Taubenberger   +10 more
doaj   +1 more source