Results 61 to 70 of about 3,311,882 (262)

Evolution and virulence of porcine epidemic diarrhea virus following in vitro and in vivo propagation

Scientific Reports
Practice of inoculating porcine epidemic diarrhea virus (PEDV) in piglets generating feedback material might influence the genetic evolution and attenuation of PEDV.
Patumporn Jermsutjarit, Sunit Mebumroong, Parin Watcharavongtip, Hongyao Lin, Angkana Tantituvanont, Kampon Kaeoket, Pablo Piñeyro, Dachrit Nilubol   +7 more
doaj   +1 more source

Using the Influenza Patient-reported Outcome (FLU-PRO) diary to evaluate symptoms of influenza viral infection in a healthy human challenge model

BMC Infectious Diseases, 2018
Background In clinical studies involving a healthy volunteer human challenge model, a valid and reliable measure to assess the evolution of patient-reported symptom type and severity following viral exposure is necessary.
Alison Han, Jiat-Ling Poon, John H. Powers, Nancy K. Leidy, Ren Yu, Matthew J. Memoli   +5 more
doaj   +1 more source

Broadly neutralizing antibodies potently inhibit cell-to-cell transmission of semen leukocyte-derived SHIV162P3

EBioMedicine, 2020
Background: HIV-1 sexual transmission occurs mostly through infected semen, which contains both free virions and infected leukocytes. Transmission initiated by infected cells has been shown by several in vitro and in vivo studies and a reduced capacity ...
Karunasinee Suphaphiphat, Monica Tolazzi, Stéphane Hua, Delphine Desjardins, Valerie Lorin, Nathalie Dereuddre-Bosquet, Hugo Mouquet, Gabriella Scarlatti, Roger Le Grand, Mariangela Cavarelli   +9 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

AUTO-TUNE: selecting the distance threshold for inferring HIV transmission clusters

Frontiers in Bioinformatics
Molecular surveillance of viral pathogens and inference of transmission networks from genomic data play an increasingly important role in public health efforts, especially for HIV-1.
Steven Weaver, Vanessa M. Dávila Conn, Daniel Ji, Hannah Verdonk, Santiago Ávila-Ríos, Andrew J. Leigh Brown, Joel O. Wertheim, Sergei L. Kosakovsky Pond   +7 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The evolution of viral diversity [PDF]

, 2012
This thesis focuses on the population dynamics of three antigenically diverse RNA viruses: dengue, influenza and HIV-1. It comprises a set of studies highlighting the roles of structural constraints on critical antigenic determinants, interactions ...
Wikramaratna, Paul Silva
core   +1 more source

Genetic Sequencing of a Bacterial Pneumonia Vaccine Produced in 1916

Vaccines
Background/Objectives: Bacterial vaccines were first developed and used in the late 1800s to prevent chicken cholera and anthrax. Bacterial pneumonia vaccines were widely used during the 1918 influenza pandemic, despite the influenza A/H1N1 virus not yet
Yongli Xiao, Sebastian M. Gygli, Tomoko Y. Steen, Jeffery K. Taubenberger   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Field Investigation Evaluating the Efficacy of Porcine Reproductive and Respiratory Syndrome Virus Type 2 (PRRSV-2) Modified Live Vaccines in Nursery Pigs Exposed to Multiple Heterologous PRRSV Strains

Animals
This study was conducted to evaluate the protective efficacy of modified live vaccines (MLVs) against porcine reproductive and respiratory syndrome (PRRS) in nursery pigs in a worst case scenario where MLV does not match the genetic profile of the field ...
Sunit Mebumroong, Hongyao Lin, Patumporn Jermsutjarit, Angkana Tantituvanont, Dachrit Nilubol   +4 more
doaj   +1 more source