Results 81 to 90 of about 4,157,307 (334)
Origin and evolution of pathogenic coronaviruses
Nature Reviews Microbiology, 2018 Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two highly transmissible and pathogenic viruses that emerged in humans at the beginning of the 21st century.
Jie Cui, Fang Li, Zhènglì Shí
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip
Microbiology Spectrum, 2021 Human-to-human transmission of viruses, such as influenza viruses and coronaviruses, can promote virus evolution and the emergence of new strains with increased potential for creating pandemics.
Longlong Si +5 more
doaj +1 more source
Co-Evolution of quasispecies: B-cell mutation rates maximize viral error catastrophes
, 2001 Co-evolution of two coupled quasispecies is studied, motivated by the competition between viral evolution and adapting immune response. In this co-adaptive model, besides the classical error catastrophe for high virus mutation rates, a second ...
A. Aigner +29 more
core +1 more source
Proceedings of the Royal Society A, 2020 By modelling the evaporation and settling of droplets emitted during respiratory releases and using previous measurements of droplet size distributions and SARS-CoV-2 viral load, estimates of the evolution of the liquid mass and the number of viral ...
P. M. Oliveira +4 more
semanticscholar +1 more source
Stochastic Modeling and Simulation of Viral Evolution [PDF]
Bulletin of Mathematical Biology, 2018 34 pages, 10 figures, 4 tables, 1 ...
Luiza Guimarães Fabreti +4 more
openaire +4 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
A novel mechanism underlying the innate immune response induction upon viral-dependent replication of host cell mRNA: A mistake of +sRNA viruses' replicases [PDF]
, 2017 Viruses are lifeless particles designed for setting virus-host interactome assuring a new generation of virions for dissemination. This interactome generates a pressure on host organisms evolving mechanisms to neutralize viral infection, which places the
Colombo, Maria Isabel +1 more
core +2 more sources
Endogenous viruses: Connecting recent and ancient viral evolution.
Virology, 2015 The rapid rates of viral evolution allow us to reconstruct the recent history of viruses in great detail. This feature, however, also results in rapid erosion of evolutionary signal within viral molecular data, impeding studies of their deep history ...
P. Aiewsakun, A. Katzourakis
semanticscholar +1 more source
Evolution of viral quasispecies during SARS-CoV-2 infection
Clinical Microbiology and Infection, 2020 Objectives Studies are needed to better understand the genomic evolution of the recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to describe genomic diversity of SARS-CoV-2 by next-generation sequencing (NGS)
A. Jary +14 more
semanticscholar +1 more source