Results 201 to 210 of about 216,108 (259)

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Zika virus and host protein interactions for understanding molecular mechanisms of pathogenesis and therapeutic development. [PDF]

Front Cell Infect Microbiol
Han X, Du J, Li W, Yang S, Sun H, Wang G, Cong H.   +6 more
europepmc   +1 more source

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

Advanced Science, EarlyView.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin, Zepeng Su, Yipeng Zeng, Yi Zhou, Chenying Zeng, Weihao Zhang, Qibo Li, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Guan Zheng, Wenhui Yu, Zhongyu Xie   +13 more
wiley   +1 more source

Cell-cell fusion limits activation of the unfolded protein response induced by the Nipah virus glycoproteins. [PDF]

J Virol
Jordan P, Heyer S, Hüther J, Fischer I, Becker N, Maisner A.   +5 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Host-Microbe Interactions: Understanding the Mechanism of Autophagy in Viral Replication and Immune Evasion. [PDF]

Vet Sci
Fu Z, Li X, Abd El-Aty AM, Yagan R, Ju X, Yong Y.   +5 more
europepmc   +1 more source

TGM2 Aggravates Acute Pancreatitis by Impairing Macrophage Efferocytosis Through Inhibition of the STAT6–GAS6 Axis

Advanced Science, EarlyView.
This study shows TGM2 is upregulated in AP, impairing macrophage efferocytosis by inhibiting the STAT6–GAS6 axis. The lactoferrin‐modified, ROS‐responsive LF‐LNP@si‐TGM2 targets pancreatic macrophages, silences TGM2, restores the axis, and alleviates AP.
Xuxu Liu, Zhiwei Du, Liyi Wang, Zhihong Xie, Ziang Meng, Yi Zheng, Heming Wang, Yuanhang He, Dongbo Xue   +8 more
wiley   +1 more source

Effect of pH on small-molecule inhibitor binding to influenza virus hemagglutinin. [PDF]

J Biol Chem
Anirudhan V, Gaisina I, Shimon A, Lee H, Alqarni S, Manicassamy B, Moore TW, Xu K, Caffrey M, Rong L.   +9 more
europepmc   +1 more source

From <i>Ex Vivo</i> to <i>In Vivo</i>: Advances in Lentiviral Vector Engineering for CAR-T Therapy. [PDF]

Immune Netw
Baek Y, Seo YR, Kim S, Jung S, Kim CH, Lee YH.   +5 more
europepmc   +1 more source