Results 221 to 230 of about 216,108 (259)

Membrane rearrangements in fusion mediated by viral proteins

Trends in Microbiology, 1997
Diverse enveloped viruses enter host cells by fusing their envelopes with cell membranes. The mechanisms of merger of lipid bilayers of two membranes mediated by influenza hemagglutinin and other viral fusion proteins apparently involve local lipidic connections that evolve into a bilayer septum in which a pore forms and expands.
G B, Melikyan, L V, Chernomordik
openaire   +2 more sources

Fusion inhibition: Bioassay of a Type C viral protein

Virology, 1975
Abstract Based on the observation that concentrated RD-114 virus directly induces fusion in a Rous sarcoma virus-transformed human glioma cell line, KC, an RD-114 virus protein was identified which had the property of inhibiting this fusion. The protein was irreversibly denatured by 2-mercaptoethanol, reacted with neutralizing sera to RD-114 virus ...
K, Rand, J, Davis, R V, Gilden, S, Oroszlan, C, Long   +4 more
openaire   +2 more sources

Inhibition of Measles Viral Fusion Is Enhanced by Targeting Multiple Domains of the Fusion Protein

ACS Nano, 2021
Measles virus (MeV) infection remains a significant public health threat despite ongoing global efforts to increase vaccine coverage. As eradication of MeV stalls, and vulnerable populations expand, effective antivirals against MeV are in high demand.
Francesca T. Bovier, Ksenia Rybkina, Sudipta Biswas, Olivia Harder, Tara C. Marcink, Stefan Niewiesk, Anne Moscona, Christopher A. Alabi, Matteo Porotto   +8 more
openaire   +3 more sources

Properties of a Viral Fusion Protein

1988
The mechanisms by which proteins mediate biological membrane fusion are not clearly understood. We have analyzed acid-induced changes in influenza hemagglutinin (HA), a viral membrane fusion factor, and correlated them with its acid-triggered fusion activity.
Robert W. Doms, Ari Helenius
openaire   +1 more source

Histidine protonation and the activation of viral fusion proteins

Biochemical Society Transactions, 2008
Many viral fusion proteins only become activated under mildly acidic condition (pH 4.5–6.5) close to the pKa of histidine side-chain protonation. Analysis of the sequences and structures of influenza HA (haemagglutinin) and flaviviral envelope glycoproteins has led to the identification of a number of histidine residues that are not only fully ...
Mueller, D., Kampmann, T., Yennamalli, R., Young, P.R., Kobe, B., Mark, A. E.   +5 more
openaire   +4 more sources

Peripherin-2:  An Intracellular Analogy to Viral Fusion Proteins

Biochemistry, 2007
The C-terminus of the intracellular retinal rod outer segment disk protein peripherin-2 binds to membranes, adopts a helical conformation, and promotes membrane fusion, which suggests an analogy to the structure and function of viral envelope fusion proteins. Nuclear magnetic resonance (NMR) data and fluorescence data show that a 63-residue polypeptide
T C, Edrington, R, Lapointe, P L, Yeagle, C L, Gretzula, K, Boesze-Battaglia   +4 more
openaire   +2 more sources

Viral proteins in cell fusion.

The Tokai journal of experimental and clinical medicine, 1983
F (fusion) and HANA (hemagglutinin and neuraminidase) glycoproteins of HVJ (Sendai virus) were purified and characterized. The NH2-terminal hydrophobic region of the F1 (larger) subunit of F (fusion)-glycoprotein seems to be required for the hemolytic and cell fusion-inducing activity of the virus for the following reasons.
A, Asano, K, Asano
openaire   +1 more source

Viral Fusion Protein TM-TM Interactions

2017
Enveloped viruses, such as HIV, influenza, and Ebola, utilize surface glycoproteins to bind and fuse with a target cell membrane. This fusion event is necessary for release of viral genomic material so the virus can ultimately reproduce and spread.
openaire   +1 more source

Pore Formation in Target Liposomes by Viral Fusion Proteins

2003
Publisher Summary This chapter introduces methodologies to characterize plasma-membrane and viral-membrane interactions in a model system using liposomes as target membranes. It focuses on hemagglutinin (HA), a trimeric integral membrane protein that protrudes from the viral membrane as a spike, with a long stem and a globular tip.
Pierre, Bonnafous, Toon, Stegmann
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Patch clamp studies of single cell-fusion events mediated by a viral fusion protein

Nature, 1989
To enter cells, viruses must fuse their envelope with a host cell membrane. Fusion is mediated by specific, membrane-spanning fusion proteins, of which the influenza virus haemagglutinins (HA) are the best characterized. Several HAs have been sequenced, and the crystal structure of the major part of one HA is known.
A E, Spruce, A, Iwata, J M, White, W, Almers   +3 more
openaire   +2 more sources