Results 221 to 230 of about 603,967 (361)

Intercellular trafficking and enhanced in vivo antitumour activity of a non-virally delivered P27-VP22 fusion protein [PDF]

, 2003
David Zavaglia, M-C Favrot, Béatrice Eymin, Christian Tenaud, Jean‐Luc Coll   +4 more
openalex   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Structure-Function Studies Link Class II Viral Fusogens with the Ancestral Gamete Fusion Protein HAP2

, 2017
Jennifer F. Pinello, Alex L. Lai, Jean K. Millet, Donna Cassidy-Hanley, Jack H. Freed, Theodore G. Clark   +5 more
openalex   +1 more source

NAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR

Advanced Science, EarlyView.
Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou, Xi Xiong, Jialong Hou, Qi Duan, Yi Zheng, Tao Jiang, Jiani Huang, Haijun He, Jiaxue Xu, Keke Chen, Wenwen Wang, Jinlai Cai, Jingjing Qian, Huijun Chen, Weihong Song, XinShi Wang, Chenglong Xie   +16 more
wiley   +1 more source

Screening and Identification of Multiple Peptides Homologous to the Fusion Glycoprotein Gc of Schmallenberg Virus Able to Inhibit Viral Infection. [PDF]

Transbound Emerg Dis
Zannella C, Grazioso R, Chianese A, Iovane V, Santella B, Montagnaro S, Greco G, Pagnini U, Franci G, Filippis A, Iovane G, Isernia C, Galdiero M.   +12 more
europepmc   +1 more source

Cell-surface expression of a mutated Epstein–Barr virus glycoprotein B allows fusion independent of other viral proteins [PDF]

, 2004
Marisa P. McShane, Richard Longnecker
openalex   +1 more source

Viral fusion protein transmembrane domain adopts β-strand structure to facilitate membrane topological changes for virus–cell fusion

Proceedings of the National Academy of Sciences of the United States of America, 2015
H. Yao, Michelle W. Lee, A. Waring, G. Wong, M. Hong   +4 more
semanticscholar   +1 more source

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source

Harnessing Antiviral Peptides: From Molecular Mechanisms to Clinical Translation. [PDF]

Curr Res Pharmacol Drug Discov
Raj A, Sharmin S, Ahmed Z, Maha TT, Bishakha AC, Akter H, Husna A, Ripa FA, Rumi F.   +8 more
europepmc   +1 more source

Proteomics computational analyses suggest that the carboxyl terminal glycoproteins of Bunyaviruses are class II viral fusion protein (beta-penetrenes). [PDF]

, 2004
Courtney E. Garry, Robert F. Garry
openalex   +1 more source