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Hepatitis Vaccines: Recent Advances and Challenges [PDF]

Vaccines
Viral hepatitis constitutes a substantial global public health challenge. The etiological agents, referred to as hepatitis viruses, are primarily categorized into five types: hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV ...
Mei Lu, Yakun Liu, Lele Li, Xueke Liu, Bin Wu, Yingping Wu   +5 more
doaj   +2 more sources

Phylodynamic Analysis Suggests That Deer Species May Be a True Reservoir for Hepatitis E Virus Genotypes 3 and 4

Microorganisms, 2023
Hepatitis E virus (HEV) genotypes 3 and 4 (HEV-3 and HEV-4) cause zoonotic infection in humans, with domestic pigs and wild boars being the main reservoirs of infection.
Anastasia A. Karlsen, Vera S. Kichatova, Karen K. Kyuregyan, Mikhail I. Mikhailov   +3 more
doaj   +1 more source

Coverage with Timely Administered Vaccination against Hepatitis B Virus and Its Influence on the Prevalence of HBV Infection in the Regions of Different Endemicity

Vaccines, 2021
Universal hepatitis B vaccination of newborns was implemented in Russia starting from 1998. From 1998 to 2019, the incidence of acute hepatitis B reduced from 43.8 to 0.57 cases per 100,000 population.
Karen K. Kyuregyan, Vera S. Kichatova, Olga V. Isaeva, Ilya A. Potemkin, Elena Yu. Malinnikova, Maria A. Lopatukhina, Anastasia A. Karlsen, Fedor A. Asadi Mobarhan, Eugeniy V. Mullin, Olga S. Slukinova, Margarita E. Ignateva, Snezhana S. Sleptsova, Elena E. Oglezneva, Elena V. Shibrik, Maria G. Isaguliants, Mikhail I. Mikhailov   +15 more
doaj   +1 more source

Geographic and Temporal Variability of Hepatitis E Virus Circulation in the Russian Federation

Viruses, 2022
The factors influencing hepatitis E virus (HEV) circulation remain largely unexplored. We investigated HEV seroprevalence in humans and the prevalence of infection in farm pigs and rabbits in different regions of the Russian Federation, as well as the ...
Mikhail I. Mikhailov, Anastasia A. Karlsen, Ilya A. Potemkin, Olga V. Isaeva, Vera S. Kichatova, Elena Yu. Malinnikova, Fedor A. Asadi Mobarkhan, Eugeniy V. Mullin, Maria A. Lopatukhina, Victor A. Manuylov, Elena P. Mazunina, Evgeniia N. Bykonia, Denis A. Kleymenov, Liubov I. Popova, Vladimir A. Gushchin, Artem P. Tkachuk, Andrey D. Polyakov, Ahmed Mohammed Eladly, Sergey A. Solonin, Ilya V. Gordeychuk, Karen K. Kyuregyan   +20 more
doaj   +1 more source

Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections [PDF]

, 2021
Background. Chronic hepatitis B and D virus (HBV/HDV) infections can cause cancer. Current HBV therapy using nucleoside analogues (NAs) is life-long and reduces but does not eliminate the risk of cancer.
Ahlén, G, Frelin, L, Jagya, N, Johansson, M, Maravelia, P, Meuleman, Philip, Ni, Y, Pasetto, A, Pater, L, Pérez, NC, Sällberg, M, Urban, S, Verch, G, Verhoye, Lieven   +13 more
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Dynamic Changes in Hepatitis A Immunity in Regions with Different Vaccination Strategies and Different Vaccination Coverage

Vaccines, 2022
The data on hepatitis A virus (HAV) seroprevalence are critical for the implementation of a universal mass vaccination (UMV) strategy. The latter has not been implemented in Russia; however, regional child vaccination programs have been adopted in some ...
Karen K. Kyuregyan, Maria A. Lopatukhina, Fedor A. Asadi Mobarkhan, Vera S. Kichatova, Ilya A. Potemkin, Olga V. Isaeva, Anastasia A. Karlsen, Elena Yu. Malinnikova, Alla N. Kaira, Tatyana V. Kozhanova, Victor A. Manuylov, Elena P. Mazunina, Evgeniia N. Bykonia, Denis A. Kleymenov, Margarita E. Ignateva, Olga E. Trotsenko, Anna V. Kuznetsova, Anna A. Saryglar, Natalia D. Oorzhak, Victor V. Romanenko, Mikhail I. Mikhailov   +20 more
doaj   +1 more source

Transfusion Transmissible Infections in Blood Donors in the Province of Bié, Angola, during a 15-Year Follow-Up, Imply the Need for Pathogen Reduction Technologies

Pathogens, 2021
Transfusion transmissible infections (TTIs), caused by hepatitis B virus (HBV), human immunode-ficiency virus (HIV), hepatitis C virus (HCV), and syphilis, have a high global impact, especially in sub-Saharan Africa.
Luis Baião Peliganga, Vinicius Motta Mello, Paulo Sergio Fonseca de Sousa, Marco Aurelio Pereira Horta, Álvaro Domingos Soares, João Pedro da Silva Nunes, Miguel Nobrega, Lia Laura Lewis-Ximenez   +7 more
doaj   +1 more source

The Inaugural Australian Centre for Hepatitis Virology Public Panel Discussion on Viral Hepatitis Research—Lessons in Scientific Community Outreach

Viruses, 2021
Viral hepatitis remains one of the most significant health issues globally, directly responsible for over 1 million deaths each year and affecting almost 300 million people around the world.
Thomas Tu, Chaturaka Rodrigo, Simone I Strasser, D Scott Bowden, Jennifer H MacLachlan, Heidi E Drummer   +5 more
doaj   +1 more source

HBV Vaccines: Advances and Development

Vaccines, 2023
Hepatitis B virus (HBV) infection is a global public health problem that is closely related to liver cirrhosis and hepatocellular carcinoma (HCC). The prevalence of acute and chronic HBV infection, liver cirrhosis, and HCC has significantly decreased as ...
Faisal Mahmood, Ruixian Xu, Maher Un Nisa Awan, Yuzhu Song, Qinqin Han, Xueshan Xia, Jia Wei, Jun Xu, Juan Peng, Jinyang Zhang   +9 more
doaj   +1 more source

Universal Single-Dose Vaccination against Hepatitis A in Children in a Region of High Endemicity

Vaccines, 2020
Since August 2012, universal single-dose vaccination in children aged at least three years has been implemented in the Republic of Tuva, which was previously the region most affected by hepatitis A in Russia.
Mikhail I. Mikhailov, Maria A. Lopatukhina, Fedor A. Asadi Mobarhan, Lyudmila Yu. Ilchenko, Tatyana V. Kozhanova, Olga V. Isaeva, Anastasiya A. Karlsen, Ilya A. Potemkin, Vera S. Kichatova, Anna A. Saryglar, Natalia D. Oorzhak, Karen K. Kyuregyan   +11 more
doaj   +1 more source