Results 41 to 50 of about 57,246 (250)

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

TLR agonists as vaccine adjuvants in the prevention of viral infections: an overview

Frontiers in Microbiology, 2023
Tol-like receptor (TLR) agonists, as potent adjuvants, have gained attention in vaccine research for their ability to enhance immune responses. This study focuses on their application in improving vaccine efficacy against key viral infections, including ...
Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara   +2 more
doaj   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

Recent advancements in combination subunit vaccine development

Human Vaccines & Immunotherapeutics, 2017
Viral structural proteins share a common nature of homotypic interactions that drive viral capsid formation. This natural process has been mimicked in vitro through recombinant technology to generate various virus-like particles (VLPs) and small subviral
Ming Tan, Xi Jiang
doaj   +1 more source

Liver disease during pregnancy: acute viral hepatitis

Annals of Hepatology, 2006
Acute viral hepatitis is the most common cause of jaundice in pregnancy. The course of most viral hepatitis infections (e.g., hepatitis A, B, C and D) is unaffected by pregnancy, however, a more severe course of viral hepatitis in pregnancy has been ...
Silvia Sookoian
doaj   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

The roles of different microRNAs in the regulation of cholesterol in viral hepatitis

Cell Communication and Signaling, 2023
Cholesterol plays a significant role in stabilizing lipid or membrane rafts, which are specific cellular membrane structures. Cholesterol is involved in numerous cellular processes, including regulating virus entry into the host cell.
Xuan Meng, Yeganeh Eslami, Ehsan Derafsh, Anwar Saihood, Nikoo Emtiazi, Saman Yasamineh, Omid Gholizadeh, Renzon Daniel Cosme Pecho   +7 more
doaj   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

Therapeutic Vaccines for Chronic Viral Infections: From Immune Modulation to Clinical Translation

Vaccines
Therapeutic vaccines are a key strategy to achieve the goal of “functional cure” of chronic viral infections, including hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), human papillomavirus (HPV), and Epstein–Barr ...
Zhuang Li, Yuan Zhang, Yiyang Zheng, Hongyu Wang, Chenyang Xu, Qing He   +5 more
doaj   +1 more source

Research progress of therapeutic vaccines for treating chronic hepatitis B

Human Vaccines & Immunotherapeutics, 2017
Hepatitis B virus (HBV) is a member of Hepadnavirus family, which leads to chronic infection in around 5% of patients with a high risk of developing liver cirrhosis, liver failure, and hepatocellular carcinoma.
Jianqiang Li, Mengru Bao, Jun Ge, Sulin Ren, Tong Zhou, Fengchun Qi, Xiuying Pu, Jia Dou   +7 more
doaj   +1 more source