Results 71 to 80 of about 57,246 (250)

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Prospects for the application of individualized integrated analysis of adverse events in vaccine clinical trials

Реальная клиническая практика: данные и доказательства
Introduction. This work is a continuation of the study of the safety of drug therapy in clinical trials, within the framework of which a decision-making algorithm based on the quantitative integral analysis of adverse events (AE) was proposed.
A. B. Verveda, G. I. Syraeva, V. B. Vasilyuk, M. V. Faraponova   +3 more
doaj   +1 more source

Association of IFN‐γ +874 T/A Polymorphism With COVID‐19 Susceptibility, Severity, and Inflammatory Response: A Case–Control Study From Southern Iran

Journal of Clinical Laboratory Analysis, EarlyView.
Graphical abstract illustrating the association between IFN‐γ +874 T/A polymorphism and COVID‐19 outcomes. TA and AA genotypes are linked to increased susceptibility, higher inflammatory markers (notably IL‐6), greater disease severity, and longer hospitalization.
Nasir Arefinia, Bahman Aghcheli, Seyed Mohammad Ali Hashemi, Zohreh‐al‐sadat Ghoreshi, Emad Behboudi   +4 more
wiley   +1 more source

Trends in hospitalizations for vaccine‐preventable diseases in the United States from 2014 to 2024

Journal of Hospital Medicine, EarlyView.
Abstract Background and Objectives Vaccination rates have declined in recent years, resulting in outbreaks of vaccine‐preventable diseases (VPDs) among children. We aimed to evaluate VPD hospitalization rates from 2014 to 2024 and to report associated trends in outcomes including intensive care utilization, mortality, readmissions, and costs.
Nathan M. Money, Erin Sullivan, Hannah Rector, Corrie E. McDaniel, Jessica L. Markham, Mersine A. Bryan   +5 more
wiley   +1 more source

Research advances in replication-deficient viral vector vaccines

Frontiers in Veterinary Science
In recent years, replication-deficient viral vector vaccines have attracted much attention in the field of vaccine research and development due to their high safety and immunogenicity.
Junna Wang, Junna Wang, Jin Cui, Guoxin Li, Lingxue Yu, Lingxue Yu   +5 more
doaj   +1 more source

Clinical progress note: Mumps

Journal of Hospital Medicine, EarlyView.
Abstract Mumps was a common childhood viral illness before the implementation of the measles, mumps, and rubella (MMR) vaccination in 1967. There was a significant decrease in mumps cases in the postvaccine era; however, there has been an increase in outbreaks in the United States over the past two decades.
Sarah Ludvigsen, Mati Segev
wiley   +1 more source

VLP (Virus-Like Particles) Vaccines - Current Knowledge and Future Directions [PDF]

Brazilian Archives of Biology and Technology
Viruses are acellular, potential pathogenic agents causing infections, ranging from acute to chronic. A wide range of conventional immunization methodologies have been employed to control viral diseases. But, their ability to mutate or remain inactive in
Prakash Meghana, Mangalam Achuthananda Iyer Jayasri, Krishnamurthy Suthindhiran   +2 more
doaj   +1 more source

Immunization and the hepatitis B virus: A view from the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Hepatology Committee

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Hepatitis B virus (HBV) infection remains a global health challenge, with more than 250 million people chronically infected worldwide and >2000 daily deaths from HBV‐related disease. Early‐life acquisition is the primary driver of chronic infection; up to 90% of infants infected perinatally progress to chronic HBV infection compared with ...
Benno Kohlmaier, Giuseppe Indolfi, Ulrich Baumann, Cristina Gonçalves, Emmanuel Gonzales, Norman Junge, Emanuele Nicastro, Tudor Lucian Pop, Jesus Quintero, Xavier Stephenne, Bethany Tucker, Hubert Van Der Doef, Orith Waisbourd‐Zinman, Emer Fitzpatrick   +13 more
wiley   +1 more source

Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections

Frontiers in Immunology, 2018
For many years, the focus of prophylactic vaccines was to elicit neutralizing antibodies, but it has become increasingly evident that T cell-mediated immunity plays a central role in controlling persistent viral infections such as with human ...
Eleni Panagioti, Eleni Panagioti, Paul Klenerman, Lian N. Lee, Sjoerd H. van der Burg, Ramon Arens   +5 more
doaj   +1 more source

Atypical Varicella‐Like Presentation of an Imported Mpox Case in Austria Confirmed to be Infected With Clade Ib

JEADV Clinical Practice, EarlyView.
ABSTRACT The recent upsurge of cases caused by the newly identified Clade Ib monkeypox virus (MPXV) in the Democratic Republic of the Congo and other countries has emerged as a significant public health concern. A 34‐year‐old male tourist from Venezuela presented in Vienna, Austria, during his travels through Europe with fever, pharyngitis and an ...
Amélie Hampel, David N. Springer, Jeremy V. Camp, Stephan W. Aberle, Maximilian Egg, Luigi Segagni Lusignani, Katharina Grabmeier‐Pfistershammer, Robert Strassl, Judith Wendt, Tamar Kinaciyan, Alessandra Handisurya   +10 more
wiley   +1 more source