Results 1 to 10 of about 3,717,929 (382)

The relationship between COVID‐19 viral load and disease severity: A systematic review

Immunity, Inflammation and Disease, 2021
Patients with COVID‐19 may present different viral loads levels. However, the relationship between viral load and disease severity in COVID‐19 is still unknown. Therefore, this study aimed to systematically review the association between SARS‐CoV‐2 viral
O. Dadras, A. Afsahi, Z. Pashaei, Hengameh Mojdeganlou, A. Karimi, Pedram Habibi, A. Barzegary, Amirata Fakhfouri, P. Mirzapour, Nazanin Janfaza, Soheil Dehghani, Fatemeh Afroughi, Mohsen Dashti, S. Khodaei, E. Mehraeen, F. Voltarelli, J. Sabatier, Seyedahmad Seyedalinaghi   +17 more
semanticscholar   +2 more sources

High Heritability Is Compatible with the Broad Distribution of Set Point Viral Load in HIV Carriers. [PDF]

PLoS Pathogens, 2015
Set point viral load in HIV patients ranges over several orders of magnitude and is a key determinant of disease progression in HIV. A number of recent studies have reported high heritability of set point viral load implying that viral genetic factors ...
Bonhoeffer, S, Fraser, C, Leventhal, GE
core   +5 more sources

Modelling upper respiratory viral load dynamics of SARS-CoV-2

BMC Medicine, 2021
Relationships between viral load, severity of illness, and transmissibility of virus are fundamental to understanding pathogenesis and devising better therapeutic and prevention strategies for COVID-19. Here we present within-host modelling of viral load
J. D. Challenger, C. Y. Foo, Yue Wu, A. Yan, M. M. Marjaneh, F. Liew, R. Thwaites, L. Okell, A. Cunnington   +8 more
semanticscholar   +2 more sources

Viral Loads in Clinical Specimens and SARS Manifestations

Emerging Infectious Diseases, 2004
A retrospective viral load study was performed on clinical specimens from154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS), prospectively collected during patients’ illness.
I.F.N. Hung, V.C.C. Cheng, A.K.L. Wu, B.S.F. Tang, K.H. Chan, C.M. Chu, M.M.L. Wong, W.T. Hui, L.L.M. Poon, D.M.W. Tse, K.S. Chan, P.C.Y. Woo, S.K.P. Lau, J.S.M. Peiris, K.Y. Yuen   +14 more
doaj   +5 more sources

How Can Viral Dynamics Models Inform Endpoint Measures in Clinical Trials of Therapies for Acute Viral Infections? [PDF]

, 2016
Acute viral infections pose many practical challenges for the accurate assessment of the impact of novel therapies on viral growth and decay. Using the example of influenza A, we illustrate how the measurement of infection-related quantities that ...
Anderson, RM, Cauët, E, Cori, A, De Wolf, F, Hadjichrysanthou, C, Lawrence, E, Vegvari, C   +6 more
core   +23 more sources

Mathematical modeling indicates that regulatory inhibition of CD8+ T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load

bioRxiv, 2023
Immunotherapeutic cytokines can activate immune cells against cancers and chronic infections. N-803 is an IL-15 superagonist that expands CD8+ T cells and increases their cytotoxicity.
J. Cody, Amy L. Ellis-Connell, Shelby L. O’Connor, E. Pienaar   +3 more
semanticscholar   +1 more source

SARS-CoV-2 viral RNA levels are not 'viral load' [PDF]

Trends in Microbiology, 2021
Ct values are commonly used as proxy of SARS-CoV-2 “viral load”. Because of the (+)ssRNA nature of coronaviruses, current RT-qPCR target amplification does not distinguish replicative from transcriptional RNA. Although Ct values analyses through time, space and biological backgrounds remain informative, equating Ct with viral load may generate ...
Michalakis, Yannis, Sofonea, Mircea, Alizon, Samuel, Bravo, Ignacio G.   +3 more
openaire   +5 more sources

Community viral load – an optimal alternative index of population viral load for HIV/AIDS surveillance

Zhongguo gonggong weisheng, 2022
ObjectiveTo explore an optimal alternative index of population viral load (PVL) suitable for assessing potential human immunodeficiency virus (HIV) transmission in the population of Yining city, Xinjiang Uygur Autonomous Region.
Qian HE, Aizimaiti·Aikebaier, Xiao-min HU   +2 more
doaj   +1 more source

SARS-CoV-2 viral load and shedding kinetics

Nature Reviews Microbiology, 2022
SARS-CoV-2 viral load and detection of infectious virus in the respiratory tract are the two key parameters for estimating infectiousness. As shedding of infectious virus is required for onward transmission, understanding shedding characteristics is ...
O. Puhach, B. Meyer, I. Eckerle
semanticscholar   +1 more source

Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2021
Importance Coronavirus disease 2019 (COVID-19) continues to spread rapidly worldwide. Neutralizing antibodies are a potential treatment for COVID-19.
R. Gottlieb, A. Nirula, Peter Chen, J. Boscia, B. Heller, J. Morris, G. Huhn, Jose Cardona, Bharat Mocherla, V. Stosor, Imad Shawa, Princy N. Kumar, A. Adams, Jacob Van Naarden, Kenneth L Custer, M. Durante, G. Oakley, A. Schade, T. Holzer, P. Ebert, R. Higgs, N. Kallewaard, J. Sabo, D. Patel, P. Klekotka, Lei-Bin Shen, D. Skovronsky   +26 more
semanticscholar   +1 more source