Results 121 to 130 of about 3,717,929 (382)

Transmissibility of COVID-19 depends on the viral load around onset in adult and symptomatic patients

PLoS ONE, 2020
Objective To investigate the relationship between viral load and secondary transmission in novel coronavirus disease 2019 (COVID-19). Methods Epidemiological and clinical data were obtained from immunocompetent laboratory-confirmed patients with COVID-19
H. Kawasuji, Y. Takegoshi, M. Kaneda, A. Ueno, Y. Miyajima, Koyomi Kawago, Y. Fukui, Y. Yoshida, Miyuki Kimura, H. Yamada, I. Sakamaki, H. Tani, Y. Morinaga, Yoshihiro Yamamoto   +13 more
semanticscholar   +1 more source

Determination of HCV genotypes and viral loads in chronic HCV infected patients of Hazara Pakistan

Virology Journal, 2011
Hepatitis C Virus (HCV) genotype and viral load are two significant predictive variables knowledge of which might persuade treatment decisions. The objective of the present study was to identify the distribution of different HCV genotypes circulating in ...
Ahmad Habib, Saif Nausheen, Nisar Muhammad, Ali Amjad, Idrees Muhammad, Bajwa Mohammad A   +5 more
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Changing how the third 95 is counted: suitable indicators for measuring U = U with findings from Taiwan

AIDS Research and Therapy
Introduction The World Health Organisation has implemented multiple HIV prevention policies and strived to achieve the 90-90-90 goal by 2020, achieving the 95-95-95 goal by 2030, which refers to 95% of patients living with HIV knowing their HIV status ...
Hsun-Yin Huang, Yu-Ching Huang, Hsiu-Yun Lo, Pei-Chun Chan, Chia-Chi Lee   +4 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

HIV Viral Load Response to Antiretroviral Therapy According to the Baseline CD4 Cell Count and Viral Load [PDF]

JAMA, 2001
It is unclear whether delay in initiation of antiretroviral therapy (ART) may lead to a poorer viral load response for patients with human immunodeficiency virus (HIV).To characterize the relationship of viral load response to ART with baseline CD4 cell count and baseline viral load.Inception cohort of 3430 therapy-naive patients with HIV, of whom 3226
Phillips, AN, Staszewski, S, Weber, R, Kirk, O, Francioli, P, Miller, V, Vernazza, P, Lundgren, Jens Dilling, Ledergerber, B   +8 more
openaire   +3 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Predicting virological decay in patients starting combination antiretroviral therapy. [PDF]

, 2016
OBJECTIVE: Model trajectories of viral load measurements from time of starting combination antiretroviral therapy (cART), and use the model to predict whether patients will achieve suppressed viral load (≤200 copies/ml) within 6-months of starting cART ...
Anastos, Andrade, Cescon, Cozzi Lepri, Diggle, Glas, Grabar, Gunthard, Hartzell, Haubrich, Herz, Ho, Knobel, Kuritzkes, Marconi, McGinnis, Mittler, Mueller, Notermans, Pence, Perelson, Polis, Riddler, Royston, Rubin, Simoni, Smith, Spector, Taylor, Taylor, Taylor, Tucker, Wei, Weintrob, Weintrob, Williams, Wu, Wu, Wu, Wu, Yamashita   +40 more
core   +4 more sources

Is Higher Viral Load in SARS-CoV-2 Associated with Death?

medRxiv, 2020
There is no proven prognostic marker or adequate number of studies in patients hospitalized for coronavirus disease 2019 (COVID19). We conducted a retrospective cohort study of patients hospitalized with COVID19 from March 14 to June 17, 2020, at Sao ...
K. Faíco-Filho, V. Passarelli, N. Bellei   +2 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source