High heritability is compatible with the broad distribution of set point viral load in HIV carriers. [PDF]
PLoS Pathogens, 2015 Set point viral load in HIV patients ranges over several orders of magnitude and is a key determinant of disease progression in HIV. A number of recent studies have reported high heritability of set point viral load implying that viral genetic factors ...
Sebastian Bonhoeffer +2 more
doaj +13 more sources
How Can Viral Dynamics Models Inform Endpoint Measures in Clinical Trials of Therapies for Acute Viral Infections? [PDF]
, 2016 Acute viral infections pose many practical challenges for the accurate assessment of the impact of novel therapies on viral growth and decay. Using the example of influenza A, we illustrate how the measurement of infection-related quantities that ...
Anderson, RM +6 more
core +11 more sources
Viral load detection and management on first line ART in rural Rwanda
BMC Infectious Diseases, 2019 Background To achieve the ambitious 90–90-90 UNAIDS targets, access to routine viral load (VL) is critical. To measure VL, Rwanda has relied on a national reference laboratory for years.
Jean de Dieu Ndagijimana Ntwali +6 more
doaj +1 more source
Trends in detectable viral load by calendar year in the Australian HIV observational database [PDF]
, 2011 Background Recent papers have suggested that expanded combination antiretroviral treatment (cART) through lower viral load may be a strategy to reduce HIV transmission at a population level.
Canavan, P. +10 more
core +3 more sources
The relationship between COVID‐19 viral load and disease severity: A systematic review
Immunity, Inflammation and Disease, 2022 Introduction Patients with COVID‐19 may present different viral loads levels. However, the relationship between viral load and disease severity in COVID‐19 is still unknown.
Omid Dadras +17 more
doaj +1 more source
Benefit of viral load testing for confirmation of immunological failure in HIV patients treated in rural Malawi. [PDF]
, 2011 Objective Viral load testing is used in the HIV programme of Chiradzulu, Malawi, to confirm the diagnosis of immunological failure to prevent unnecessary switching to second-line therapy.
Badri +14 more
core +2 more sources
Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoring. [PDF]
, 2009 In high-income countries, viral load is routinely measured to detect failure of antiretroviral therapy (ART) and guide switching to second-line ART. Viral load monitoring is not generally available in resource-limited settings. We examined switching from
Boulle, A +18 more
core +4 more sources
Initiation of HIV therapy [PDF]
, 2010 In this paper, we numerically show that the dynamics of the HIV system is sensitive to both the initial condition and the system parameters. These phenomena imply that the system is chaotic and exhibits a bifurcation behavior.
BINGO WING-KUEN LING +2 more
core +1 more source
Understanding HIV Viral Load [PDF]
Canadian Journal of Public Health, 2008 This paper provides an overview of HIV viral loads in blood and genital fluids and how these relate to HIV transmission during sexual activity. Current knowledge around HIV viral loads and transmission are then discussed in relation to HIV disclosure laws in Canada.
Patrick, O'Byrne, Paul A, MacPherson
openaire +2 more sources
Measuring Population Transmission Potential for HIV: An Alternative Metric of Transmission Risk in Men who have Sex with Men (MSM) in the US [PDF]
, 2012 Background Various metrics for HIV burden and treatment success [e.g. HIV prevalence, community viral load (CVL), population viral load (PVL), percent of HIV-positive persons with undetectable viral load] have important public health limitations for ...
del Rio, Carlos +7 more
core +2 more sources