Results 201 to 210 of about 266,755 (262)

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Dynamic Changes of T Lymphocyte Subsets in Chronic Hepatitis B and Their Predictive Significance for HBV Viral Load

Huang Y, Zhang Q, Cheng X, Lei L, Xu Q, Zhang L.   +5 more
europepmc   +1 more source

Enhancing Data-Driven Decision-Making in HIV Care With Viral Load and Early Infant Diagnosis Data Dashboards in Côte d'Ivoire: Qualitative Study. [PDF]

JMIR Hum Factors
He Y, Kouabenan YR, Assoa PH, Puttkammer N, Gloyd S, Hoffman N, Wagenaar BH, Iiams-Hauser C, Komena P, Kamelan NPF, Pongathie AS, Flowers J, Abiola N, Kohemun N, Amani JK, Adje-Toure C, Perrone LA.   +16 more
europepmc   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

A luminescence-based point-of-care HIV viral load test for antiretroviral therapy monitoring. [PDF]

Lab Chip
Kim S, Hong HR, Oh JM, Chun J, Chellappaa A, Yoo J, Husain SM, Lee J, Kim J, Thirumalaraju P, Song Y, Kanakasabapathy MK, Gwak J, Hardie JM, Kuritzkes DR, Li JZ, Tsibris AM, Shafiee H.   +17 more
europepmc   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Point-of-care HIV viral load testing in a community antiretroviral therapy delivery programme: A randomised controlled trial (PHILA). [PDF]

PLOS Glob Public Health
Dorward J, Tlhaku K, Sookrajh Y, Munatsi P, Naidoo J, Tselana E, Maphumulo A, Mbambo N, Mhlongo-Gumbi T, Brown JA, Lewis L, Moodley P, Samsunder N, Drain PK, Butler CC, Hayward G, Garrett N.   +16 more
europepmc   +1 more source

AIM2-mediated pyroptosis correlates with viral load and liver injury in children with primary Epstein-Barr virus infection. [PDF]

BMC Pediatr
Wu Y, Huang J, Zheng W, Shi H, Wen Z, Jin L, Sun Y.   +6 more
europepmc   +1 more source

Comparative Assessment of Viral Load Retention in Surgical and Fabric Masks Worn by COVID-19 Patients. [PDF]

Viruses
Eller CM, Rebello MP, Sálvio A, Silva ESRF, Belo VS, Lemos ERE, Giovanetti M, De Barros JJF, Horta MA.   +8 more
europepmc   +1 more source

Correlates of quality of life in people living with HIV infection beyond viral load suppression in Africa: a scoping review. [PDF]

BMJ Public Health
Nomatshila ZB, Apalata TR, Crockett R, O'Donnell R.   +3 more
europepmc   +1 more source