Results 251 to 260 of about 2,160,512 (289)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

Viral Load Suppression Associated With Undisclosed HIV Status Among Adolescents Aged 10 to 19 Years Living With HIV in Low- and Middle-Income Countries: Protocol for a Scoping Review. [PDF]

JMIR Res Protoc
Lowane MP, Oladimeji O.
europepmc   +1 more source

Finger Prick dried blood spot for HIV viral load measurement in field conditions in Zimbabwe [PDF]

, 2015
Cowan, FM
core  

Determinants of HIV viral load suppression rates in Amhara region, Ethiopia with a large number of internally displaced people. [PDF]

J Migr Health
Yismaw G, Yenesew MA, Kebebaw T, Hinyard L, Gizaw A, Mequanint A, Hendrix C, Abate G.   +7 more
europepmc   +1 more source

Barriers and facilitators to HIV viral load suppression among adolescents living with HIV in Lubumbashi, Democratic Republic of the Congo: A qualitative study. [PDF]

PLoS One
Mukuku O, Govender K, Wembonyama SO.
europepmc   +1 more source

Viral load suppression and HIV-1 drug resistance mutations in persons with HIV on TLD/TAFED in Zambia. [PDF]

PLoS One
Luwaya EL, Mwape L, Bwalya K, Siakabanze C, Hamooya BM, Masenga SK.   +5 more
europepmc   +1 more source