A comparative analysis of viral matrix proteins using disorder predictors [PDF]
Virology Journal, 2008 Background A previous study (Goh G.K.-M., Dunker A.K., Uversky V.N. (2008) Protein intrinsic disorder toolbox for comparative analysis of viral proteins. BMC Genomics. 9 (Suppl.
Dunker A Keith +2 more
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A calcium-fortified viral matrix protein. [PDF]
Structure, 2014 In this issue of Structure, Leyrat and colleagues provide the first structural analysis of the human metapneumovirus (HMPV) matrix protein, a key regulator of viral assembly. Though structurally similar to other matrix proteins, two calcium binding sites suggest intriguing differences in regulation.
Amarasinghe GK, Dutch RE.
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Restriction of Viral Replication by Mutation of the Influenza Virus Matrix Protein [PDF]
Journal of Virology, 2002 ABSTRACT The matrix protein (M1) of influenza virus plays an essential role in viral assembly and has a variety of functions, including association with influenza virus ribonucleoprotein (RNP). Our previous studies show that the association of M1 with viral RNA and nucleoprotein not only promotes formation of helical RNP but also is required ...
Teresa Liu, Zhiping Ye
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The ATPase ATP6V1A facilitates rabies virus replication by promoting virion uncoating and interacting with the viral matrix protein. [PDF]
J Biol Chem, 2021 Rabies virus (RABV) causes severe rabies, which still poses a great threat to human and animal health worldwide due to its almost 100% mortality rate. There is no effective therapy for this lethal disease. A better understanding of the mechanism of RABV infection is important to develop effective therapies.
Liu X +11 more
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Association of Influenza Virus Proteins with Membrane Rafts [PDF]
Advances in Virology, 2011 Assembly and budding of influenza virus proceeds in the viral budozone, a domain in the plasma membrane with characteristics of cholesterol/sphingolipid-rich membrane rafts.
Michael Veit, Bastian Thaa
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The Human Respiratory Syncytial Virus Matrix Protein Is Required for Maturation of Viral Filaments [PDF]
Journal of Virology, 2012 ABSTRACT An experimental system was developed to generate infectious human respiratory syncytial virus (HRSV) lacking matrix (M) protein expression (M-null virus) from cDNA. The role of the M protein in virus assembly was then examined by infecting HEp-2 and Vero cells with the M-null virus and assessing the impact on infectious virus ...
Ruchira Mitra +4 more
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Mechanisms of phosphatidylserine influence on viral production: A computational model of Ebola virus matrix protein assembly [PDF]
Journal of Biological Chemistry, 2022 AbstractEbola virus (EBOV) infections continue to pose a global public health threat, with high mortality rates and sporadic outbreaks in Central and Western Africa. A quantitative understanding of the key processes driving EBOV assembly and budding could provide valuable insights to inform drug development.
Xiao Liu +5 more
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Efficient SIVcpz replication in human lymphoid tissue requires viral matrix protein adaptation [PDF]
Journal of Clinical Investigation, 2012 SIVs infecting wild-living apes in west central Africa have crossed the species barrier to humans on at least four different occasions, one of which spawned the AIDS pandemic. Although the chimpanzee precursor of pandemic HIV-1 strains must have been able to infect humans, the capacity of SIVcpz strains to replicate in human lymphoid tissues (HLTs) is ...
Frédéric Bibollet‐Ruche +9 more
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Chicken bromodomain-containing protein 2 interacts with the Newcastle disease virus matrix protein and promotes viral replication [PDF]
Veterinary Research, 2020 Bromodomain-containing protein 2 (BRD2) is a nucleus-localized serine-threonine kinase that plays pivotal roles in the transcriptional control of diverse genes.
Zhiqiang Duan +7 more
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Purified matrix protein of vesicular stomatitis virus blocks viral transcription in vitro. [PDF]
Proceedings of the National Academy of Sciences, 1982 One of the major structural proteins of vesicular stomatitis virus is a small, nonglycosylated, matrix protein which associates with the nucleocapsid core during final stages of morphogenesis and budding. Biochemical and genetic studies suggested that the matrix protein regulates RNA synthesis both in vitro and in vivo.
Bishnu P. De +3 more
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