Chicken bromodomain-containing protein 2 interacts with the Newcastle disease virus matrix protein and promotes viral replication [PDF]
Veterinary Research, 2020 Bromodomain-containing protein 2 (BRD2) is a nucleus-localized serine-threonine kinase that plays pivotal roles in the transcriptional control of diverse genes.
Zhiqiang Duan +7 more
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Computational Drug Design against Ebola Virus Targeting Viral Matrix Protein VP30
Borneo Journal of Pharmacy, 2019 Ebola viral disease (EVD) is a deadly infectious hemorrhagic viral fever caused by the Ebola virus with a high mortality rate. Until date, there is no effective drug or vaccination available to combat this condition.
Arthi Venkatesan +2 more
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Paramyxovirus matrix protein redirects METTL3 for dual regulation of viral replication and immune evasion. [PDF]
PLoS PathogensN6-methyladenosine (m6A) epitranscriptomic modifications play crucial roles in regulating both host and viral gene expression. Here, we revealed a novel mechanism by which paramyxoviruses exploit host m6A machinery to simultaneously enhance viral ...
Takashi Okura +15 more
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A calcium-fortified viral matrix protein. [PDF]
Structure, 2014 In this issue of Structure, Leyrat and colleagues provide the first structural analysis of the human metapneumovirus (HMPV) matrix protein, a key regulator of viral assembly. Though structurally similar to other matrix proteins, two calcium binding sites suggest intriguing differences in regulation.
Amarasinghe GK, Dutch RE.
europepmc +4 more sources
Restriction of Viral Replication by Mutation of the Influenza Virus Matrix Protein [PDF]
Journal of Virology, 2002 ABSTRACT The matrix protein (M1) of influenza virus plays an essential role in viral assembly and has a variety of functions, including association with influenza virus ribonucleoprotein (RNP). Our previous studies show that the association of M1 with viral RNA and nucleoprotein not only promotes formation of helical RNP but also is required ...
Teresa Liu, Zhiping Ye
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The Interactions of Viral Matrix Proteins with Membranes [PDF]
Biophysical Journal, 2011 Matrix proteins form the main structure of an enveloped virus, connecting the nucleocapsid to the phospholipid membrane. We have studied the M1 proteins from HRSV and Influenza A to determine their structural characteristics and the nature of their lipid binding.
James A. Freeth +2 more
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Annexin A2 gene interacting with viral matrix protein to promote bovine ephemeral fever virus release. [PDF]
J Vet Sci, 2020 Bovine ephemeral fever virus (BEFV) causes bovine ephemeral fever, which can produce considerable economic damage to the cattle industry. However, there is limited experimental evidence regarding the underlying mechanisms of BEFV. Annexin A2 (AnxA2) is a calcium and lipid-conjugated protein that binds phospholipids and the cytoskeleton in a Ca2 ...
Chen L, Li X, Wang H, Hou P, He H.
europepmc +4 more sources
Interaction of Human Parainfluenza Virus Type 3 Nucleoprotein with Matrix Protein Mediates Internal Viral Protein Assembly [PDF]
Journal of Virology, 2015 ABSTRACT Human parainfluenza virus type 3 (HPIV3) belongs to the Paramyxoviridae family. Its three internal viral proteins, the nucleoprotein (N), the phosphoprotein (P), and the polymerase (L), form the ribonucleoprotein (RNP) complex, which encapsidates the viral genome and associates with the matrix ...
Guangyuan Zhang +3 more
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Matrix protein 1 (M1) of influenza A virus: structural and functional insights [PDF]
Emerging Microbes and InfectionsEnveloped viruses rely on matrix proteins for structural integrity and lifecycle progression. Matrix protein 1 (M1) is the most abundant structural protein of influenza A virus (IAV), playing a multifaceted role in viral uncoating, polymerase activity ...
Yanting Zhu +7 more
doaj +2 more sources
Salinomycin Inhibits Influenza Virus Infection by Disrupting Endosomal Acidification and Viral Matrix Protein 2 Function. [PDF]
J Virol, 2018 Influenza virus is a main cause of viral respiratory infection in humans as well as animals, occasionally with high mortality. Circulation of influenza viruses resistant to the matrix protein 2 (M2) inhibitor, amantadine, is highly prevalent. Moreover, the frequency of detection of viruses resistant to the neuraminidase inhibitors, including ...
Jang Y +8 more
europepmc +4 more sources