Nuclear localization of Newcastle disease virus matrix protein promotes virus replication by affecting viral RNA synthesis and transcription and inhibiting host cell transcription [PDF]
Veterinary Research, 2019 Nuclear localization of paramyxovirus proteins is crucial for virus life cycle, including the regulation of viral replication and the evasion of host immunity.
Zhiqiang Duan +5 more
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Purified matrix protein of vesicular stomatitis virus blocks viral transcription in vitro. [PDF]
Proceedings of the National Academy of Sciences, 1982 One of the major structural proteins of vesicular stomatitis virus is a small, nonglycosylated, matrix protein which associates with the nucleocapsid core during final stages of morphogenesis and budding. Biochemical and genetic studies suggested that the matrix protein regulates RNA synthesis both in vitro and in vivo.
Bishnu P. De +3 more
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The Matrix Protein of Measles Virus Regulates Viral RNA Synthesis and Assembly by Interacting with the Nucleocapsid Protein [PDF]
Journal of Virology, 2009 ABSTRACT The genome of measles virus (MV) is encapsidated by the nucleocapsid (N) protein and associates with RNA-dependent RNA polymerase to form the ribonucleoprotein complex. The matrix (M) protein is believed to play an important role in MV assembly by linking the ribonucleoprotein complex with envelope glycoproteins.
Masaharu Iwasaki +5 more
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Vesicular Stomatitis Virus Matrix Protein Mutations That Affect Association with Host Membranes and Viral Nucleocapsids [PDF]
Journal of Biological Chemistry, 2008 Viral matrix (M) proteins bind the nucleoprotein core (nucleocapsid) to host membranes during the process of virus assembly by budding. Previous studies using truncated M proteins had implicated the N-terminal 50 amino acids of the vesicular stomatitis virus M protein in binding both membranes and nucleocapsids and a sequence from amino acids 75-106 as
Brooke A. Dancho +3 more
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Mechanisms of phosphatidylserine influence on viral production: A computational model of Ebola virus matrix protein assembly [PDF]
Journal of Biological Chemistry, 2022 AbstractEbola virus (EBOV) infections continue to pose a global public health threat, with high mortality rates and sporadic outbreaks in Central and Western Africa. A quantitative understanding of the key processes driving EBOV assembly and budding could provide valuable insights to inform drug development.
Xiao Liu +5 more
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Efficient HIV-1 replication can occur in the absence of the viral matrix protein [PDF]
The EMBO Journal, 1998 Matrix (MA), a major structural protein of retroviruses, is thought to play a critical role in several steps of the HIV-1 replication cycle, including the plasma membrane targeting of Gag, the incorporation of envelope (Env) glycoproteins into nascent particles, and the nuclear import of the viral genome in non-dividing cells.
Heide Reil
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Cell Death and Disease, 2023 Influenza virus is one of the most challenging viruses threating human health. Since infection with influenza virus triggers inflammatory responses and induces cell death, the molecular and cellular mechanisms by which the virus-infected cells undergo ...
Chang-Ung Kim +4 more
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A comparative analysis of viral matrix proteins using disorder predictors [PDF]
Virology Journal, 2008 Background A previous study (Goh G.K.-M., Dunker A.K., Uversky V.N. (2008) Protein intrinsic disorder toolbox for comparative analysis of viral proteins. BMC Genomics. 9 (Suppl.
Dunker A Keith +2 more
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Efficient SIVcpz replication in human lymphoid tissue requires viral matrix protein adaptation [PDF]
Journal of Clinical Investigation, 2012 SIVs infecting wild-living apes in west central Africa have crossed the species barrier to humans on at least four different occasions, one of which spawned the AIDS pandemic. Although the chimpanzee precursor of pandemic HIV-1 strains must have been able to infect humans, the capacity of SIVcpz strains to replicate in human lymphoid tissues (HLTs) is ...
Frédéric Bibollet‐Ruche +9 more
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The Matrix Protein of a Plant Rhabdovirus Mediates Superinfection Exclusion by Inhibiting Viral Transcription [PDF]
Journal of Virology, 2019 Superinfection exclusion (SIE) is a widespread phenomenon in which an established virus infection prevents reinfection by closely related viruses. Understanding the mechanisms governing SIE will not only advance our basic knowledge of virus infection cycles but may also lead to improved design of antiviral measures. Despite the significance of SIE, our
Xin Zhou +4 more
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