Results 11 to 20 of about 700,286 (324)

Computational Drug Design against Ebola Virus Targeting Viral Matrix Protein VP30

Borneo Journal of Pharmacy, 2019
Ebola viral disease (EVD) is a deadly infectious hemorrhagic viral fever caused by the Ebola virus with a high mortality rate. Until date, there is no effective drug or vaccination available to combat this condition.
Arthi Venkatesan, Lavanya Ravichandran, J Febin Prabhu Dass   +2 more
doaj   +4 more sources

Subunit interactions of vesicular stomatitis virus envelope glycoprotein stabilized by binding to viral matrix protein [PDF]

Journal of Virology, 1992
The mechanism by which viral glycoproteins are incorporated into virus envelopes during budding from host membranes is a major question of virus assembly. Evidence is presented here that the envelope glycoprotein (G protein) of vesicular stomatitis virus binds to the viral matrix protein (M protein) in vitro with the specificity, reversibility, and ...
Douglas S. Lyles, Margie O. McKenzie, J. Wallace Parce   +2 more
semanticscholar   +5 more sources

Efficient HIV-1 replication can occur in the absence of the viral matrix protein [PDF]

The EMBO Journal, 1998
Matrix (MA), a major structural protein of retroviruses, is thought to play a critical role in several steps of the HIV-1 replication cycle, including the plasma membrane targeting of Gag, the incorporation of envelope (Env) glycoproteins into nascent particles, and the nuclear import of the viral genome in non-dividing cells.
Heide Reil
semanticscholar   +5 more sources

Role of Viral Hemorrhagic Septicemia Virus Matrix (M) Protein in Suppressing Host Transcription [PDF]

Journal of Virology, 2017
ABSTRACT Viral hemorrhagic septicemia virus (VHSV) is a pathogenic fish rhabdovirus found in discrete locales throughout the Northern Hemisphere. VHSV infection of fish cells leads to upregulation of the host's virus detection response, but the virus quickly suppresses interferon (IFN) production and antiviral gene expression.
Ke Qi, Wade Weaver, Adam Pore, Bartolomeo Gorgoglione, Julia H Wildschutte, Pengfeng Xiao, Brian S. Shepherd, Allyn Spear, Krishnamurthy Malathi, Carol A. Stepien, Vikram N. Vakharia, Douglas W. Leaman   +11 more
semanticscholar   +8 more sources

Nuclear export of influenza viral ribonucleoprotein is temperature-dependently inhibited by dissociation of viral matrix protein

Virology, 2003
The influenza virus copies its genomic RNA in the nuclei of host cells, but the viral particles are formed at the plasma membrane. Thus, the export of new genome from the nucleus into the cytoplasm is essential for viral production. Several viral proteins, such as nucleoprotein (NP) and RNA polymerases, synthesized in the cytoplasm, are imported into ...
A. Sakaguchi, Etsuko Hirayama, Akihiro Hiraki, Yoichi Ishida, Jeman Kim   +4 more
semanticscholar   +5 more sources

Ubiquitin-regulated nuclear-cytoplasmic trafficking of the Nipah virus matrix protein is important for viral budding. [PDF]

PLoS Pathogens, 2010
Paramyxoviruses are known to replicate in the cytoplasm and bud from the plasma membrane. Matrix is the major structural protein in paramyxoviruses that mediates viral assembly and budding.
Yao E Wang, Arnold Park, Michael Lake, Mickey Pentecost, Betsabe Torres, Tatyana E Yun, Mike C Wolf, Michael R Holbrook, Alexander N Freiberg, Benhur Lee   +9 more
doaj   +6 more sources

Inhibition of the Protease Activity of Influenza Virus RNA Polymerase PA Subunit by Viral Matrix Protein [PDF]

Microbiology and Immunology, 2003
AbstractInfluenza virus PA is a subunit of RNA‐dependent RNA polymerase. We demonstrated that PA has a unique chymotrypsin‐like serine protease activity with Ser624 as an active site. To obtain further insight into the role of the protease activity of PA in viral proliferation, we examined the interaction between PA and matrix protein (M1).
Koyu Hara, Mayumi Shiota, Hiroshi Kido, Ken Watanabe, Kyosuke Nagata, Tetsuya Toyoda   +5 more
semanticscholar   +4 more sources

Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding

EMBO reports, 2022
Phosphatidylserine (PS) is a critical lipid factor in the assembly and spread of numerous lipid-enveloped viruses. Here, we describe the ability of the Ebola virus (EBOV) matrix protein eVP40 to induce clustering of PS and promote viral budding in vitro, as well as the ability of an FDA-approved drug, fendiline, to reduce PS clustering and subsequent ...
Monica L Husby, Souad Amiar, Laura I Prugar, Emily A David, Caroline B Plescia, Kathleen E Huie, Jennifer M Brannan, John M Dye, Elsje Pienaar, Robert V Stahelin   +9 more
openaire   +3 more sources

The Matrix Protein of a Plant Rhabdovirus Mediates Superinfection Exclusion by Inhibiting Viral Transcription [PDF]

Journal of Virology, 2019
Superinfection exclusion (SIE) is a widespread phenomenon in which an established virus infection prevents reinfection by closely related viruses. Understanding the mechanisms governing SIE will not only advance our basic knowledge of virus infection cycles but may also lead to improved design of antiviral measures. Despite the significance of SIE, our
Andrew O. Jackson, Kai Sun, Xin Zhou, Zhenghe Li, Zhenghe Li, Xueping Zhou   +5 more
openaire   +5 more sources

Effect of Influenza Virus Matrix Protein and Viral RNA on Ribonucleoprotein Formation and Nuclear Export

Virology, 2001
The formation of influenza virus ribonucleoprotein (RNP) is a necessary step in viral assembly and maturation in infected cells, but the mechanism remains incompletely understood. Influenza virus proteins such as matrix (M1) and cellular proteins have been implicated in assembly and transport of RNP.
Xiaoyuan Huang, Teresa Liu, Jacqueline Müller, Roland A. Levandowski, Zhiping Ye   +4 more
openalex   +4 more sources