Intracellular Behavior of Rabies Virus Matrix Protein (M) Is Determined by the Viral Glycoprotein (G) [PDF]
Microbiology and Immunology, 1999 AbstractTo investigate the nature and intracellular behavior of the matrix (M) protein of an avirulent strain (HEP‐Flury) of rabies virus, we cloned and sequenced the cDNA of the protein. Using expression vectors pZIP‐NeoSV(X)1 and pCDM8, the cDNA was transfected to animal cells (BHK‐21 and COS‐7) with or without coexpression of viral glycoprotein (G).
Koichiro Nakahara +6 more
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Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry. [PDF]
PLoS Pathogens, 2012 Protein phosphorylation is a common post-translational modification in eukaryotic cells and has a wide range of functional effects. Here, we used mass spectrometry to search for phosphorylated residues in all the proteins of influenza A and B viruses--to
Edward C Hutchinson +8 more
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The Matrix Protein of Measles Virus Regulates Viral RNA Synthesis and Assembly by Interacting with the Nucleocapsid Protein [PDF]
Journal of Virology, 2009 ABSTRACT The genome of measles virus (MV) is encapsidated by the nucleocapsid (N) protein and associates with RNA-dependent RNA polymerase to form the ribonucleoprotein complex. The matrix (M) protein is believed to play an important role in MV assembly by linking the ribonucleoprotein complex with envelope glycoproteins.
Masaharu Iwasaki +5 more
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Influenza A matrix protein M1 induces lipid membrane deformation via protein multimerization [PDF]
bioRxiv, 2019 The matrix protein M1 of the Influenza A virus (IAV) is supposed to mediate viral assembly and budding at the plasma membrane (PM) of infected cells. In order for a new viral particle to form, the PM lipid bilayer has to bend into a vesicle toward the ...
Chiantia, Salvatore +2 more
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Characterization of a Slow‐Migrating Component of the Rabies Virus Matrix Protein Strongly Associated with the Viral Glycoprotein [PDF]
Microbiology and Immunology, 2003 AbstractWe investigated multiple forms of rabies virus matrix (M) protein. Under non‐reducing electrophoretic conditions, we detected, in addition to major bands of monomer forms (23‐ and 24‐kDa) of M protein, an M antigen‐positive slow‐migrating minor band (about 54 kDa) in both the virion and infected cells.
Tomomi Nakahara +6 more
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Medical Immunology (Russia), 2023 The reproductive potential of both women and men is declining every year. Many factors contribute to the violation of the reproductive function – chemical, physical, mechanical, psychogenic, however, biological factors have the most pronounced effect on reproduction.
T. А. Nevezhkina +7 more
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The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response. [PDF]
PLoS Pathogens, 2016 For efficient replication, viruses have developed mechanisms to evade innate immune responses, including the antiviral type-I interferon (IFN-I) system.
Preeti Bharaj +9 more
doaj +2 more sources
Veterinary Research, 2019 Nuclear localization of paramyxovirus proteins is crucial for virus life cycle, including the regulation of viral replication and the evasion of host immunity.
Zhiqiang Duan +5 more
doaj +2 more sources
The Matrix Protein of Vesicular Stomatitis Virus Binds Dynamin for Efficient Viral Assembly [PDF]
Journal of Virology, 2010 ABSTRACT Matrix proteins (M) direct the process of assembly and budding of viruses belonging to the Mononegavirales order. Using the two-hybrid system, the amino-terminal part of vesicular stomatitis virus (VSV) M was shown to interact with dynamin pleckstrin homology domain. This interaction was confirmed
Danielle Blondel +5 more
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In silico screening of sugar alcohol compounds to inhibit viral matrix protein VP40 of Ebola virus
Molecular Biology Reports, 2019 Ebola virus is a virulent pathogen that causes highly lethal hemorrhagic fever in human and non-human species. The rapid growth of this virus infection has made the scenario increasingly complicated to control the disease. Receptor viral matrix protein (VP40) is highly responsible for the replication and budding of progeny virus.
Nagasundaram Nagarajan +3 more
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