Results 41 to 50 of about 300,470 (289)
The Ebola virus matrix protein clusters phosphatidylserine, a critical step in viral budding [PDF]
, 2021 AbstractPhosphatidylserine (PS) has been shown to be a critical lipid factor in the assembly and spread of numerous lipid enveloped viruses. Here, we describe the ability of the Ebola virus (EBOV) matrix protein eVP40 to induce clustering of PS and promote viral budding in vitro, as well as the ability of an FDA approved drug, fendiline, to reduce PS ...
Monica L. Husby +9 more
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Virology, 2003 The influenza virus copies its genomic RNA in the nuclei of host cells, but the viral particles are formed at the plasma membrane. Thus, the export of new genome from the nucleus into the cytoplasm is essential for viral production. Several viral proteins, such as nucleoprotein (NP) and RNA polymerases, synthesized in the cytoplasm, are imported into ...
Sakaguchi, Atsushi +4 more
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Molecular Mechanism of Arenavirus Assembly and Budding
Viruses, 2012 Arenaviruses have a bisegmented negative-strand RNA genome, which encodes four viral proteins: GP and NP by the S segment and L and Z by the L segment. These four viral proteins possess multiple functions in infection, replication and release of progeny ...
Shuzo Urata, Jiro Yasuda
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Biomedicines, 2022 Oncolytic viruses represent interesting anti-cancer agents with high tumor selectivity and immune stimulatory potential. The present review provides an update of the molecular mechanisms of the anti-neoplastic and immune stimulatory properties of the ...
Volker Schirrmacher
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The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response. [PDF]
PLoS Pathogens, 2016 For efficient replication, viruses have developed mechanisms to evade innate immune responses, including the antiviral type-I interferon (IFN-I) system.
Preeti Bharaj +9 more
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Intracellular Transport of HIV-1 Matrix Protein Associated with Viral RNA
World Journal of AIDS, 2013 HIV-1 matrix protein (MA) is a multifunctional structural protein localized on N terminus of Gag precursor p55. MA participates in HIV-1 assembly as membranotropic part of Gag precursor as well as an individual protein spliced from Gag early in infection. MA is found in the nuclei of infected cells and in plasma membrane, the site of virus assembly, in
Anatoliy I. Gozhenko +4 more
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Ubiquitin-regulated nuclear-cytoplasmic trafficking of the Nipah virus matrix protein is important for viral budding. [PDF]
PLoS Pathogens, 2010 Paramyxoviruses are known to replicate in the cytoplasm and bud from the plasma membrane. Matrix is the major structural protein in paramyxoviruses that mediates viral assembly and budding.
Yao E Wang +9 more
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Nucleocytoplasmic Shuttling of Influenza A Virus Proteins
Viruses, 2015 Influenza viruses transcribe and replicate their genomes in the nuclei of infected host cells. The viral ribonucleoprotein (vRNP) complex of influenza virus is the essential genetic unit of the virus.
Jing Li +3 more
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Virus Research, 2011 Chandipura virus (CV; genus Vesiculovirus, family Rhabdoviridae) is an emerging arbovirus, responsible for a number of outbreaks of severe viral encephalitis affecting children in India. A reverse genetics system has been constructed which allows recovery of infectious recombinant CV (rCV) entirely from cDNA.
Anthony C, Marriott, Crystal A, Hornsey
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Association of Influenza Virus Proteins with Membrane Rafts
Advances in Virology, 2011 Assembly and budding of influenza virus proceeds in the viral budozone, a domain in the plasma membrane with characteristics of cholesterol/sphingolipid-rich membrane rafts.
Michael Veit, Bastian Thaa
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