Results 51 to 60 of about 700,286 (324)
Biomedicines, 2022 Oncolytic viruses represent interesting anti-cancer agents with high tumor selectivity and immune stimulatory potential. The present review provides an update of the molecular mechanisms of the anti-neoplastic and immune stimulatory properties of the ...
Volker Schirrmacher
doaj +1 more source
Molecular Mechanism of Arenavirus Assembly and Budding
Viruses, 2012 Arenaviruses have a bisegmented negative-strand RNA genome, which encodes four viral proteins: GP and NP by the S segment and L and Z by the L segment. These four viral proteins possess multiple functions in infection, replication and release of progeny ...
Shuzo Urata, Jiro Yasuda
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ANP32B is a nuclear target of henipavirus M proteins. [PDF]
PLoS ONE, 2014 Membrane envelopment and budding of negative strand RNA viruses (NSVs) is mainly driven by viral matrix proteins (M). In addition, several M proteins are also known to be involved in host cell manipulation.
Anja Bauer +10 more
doaj +1 more source
Matrix protein Osteonectin (SPARC) reduces inflammation and mortality during viral myocarditis [PDF]
European Heart Journal, 2013 Rationale: Acute viral myocarditis (VM) is one of the leading causes of heart failure in young adults, lacking specific therapy. Osteonection (SPARC) is a non-structural matrix protein modulating cell-matrix interaction in the heart, and has been implicated in cardiac remodeling.
M. Rienks +6 more
openaire +2 more sources
Understanding Viral Transmission Behavior via Protein Intrinsic Disorder Prediction: Coronaviruses [PDF]
, 2012 Besides being a common threat to farm animals and poultry, coronavirus (CoV) was responsible for the human severe acute respiratory syndrome (SARS) epidemic in 2002-4. However, many aspects of CoV behavior, including modes of its transmission, are yet to
Dunker, A. Keith +2 more
core +3 more sources
Nipah shell disorder, modes of infection, and virulence [PDF]
, 2020 The Nipah Virus (NiV) was first isolated during a 1998–9 outbreak in Malaysia. The outbreak initially infected farm pigs and then moved to humans from pigs with a case-fatality rate (CFR) of about 40%.
Dunker, A. Keith +3 more
core +1 more source
International Journal of Infectious Diseases, 2023 Intro: Influenza A virus, a respiratory pathogen known to manipulate various cellular metabolic processes including glycolysis. Our earlier studies demonstrated the interaction of influenza A viral structural proteins; nucleoprotein and matrix protein ...
P. Goyal, M.S. Rajala
doaj
Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity [PDF]
, 2017 Indexación: Web of Science; Scopus.The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide.
Acevedo-Acevedo, O. +7 more
core +1 more source
The Ebola virus matrix protein clusters phosphatidylserine, a critical step in viral budding [PDF]
, 2021 AbstractPhosphatidylserine (PS) has been shown to be a critical lipid factor in the assembly and spread of numerous lipid enveloped viruses. Here, we describe the ability of the Ebola virus (EBOV) matrix protein eVP40 to induce clustering of PS and promote viral budding in vitro, as well as the ability of an FDA approved drug, fendiline, to reduce PS ...
Kathleen E. Huie +9 more
openaire +2 more sources