Results 291 to 300 of about 664,008 (371)

Oxadiazols: a New Class of Rationally Designed Anti-Human Immunodeficiency Virus Compounds Targeting the Nuclear Localization Signal of the Viral Matrix Protein

, 2005
Omar K. Haffar, Larisa Dubrovsky, Richard Lowe, Reem Berro, Fatah Kashanchi, Jeffrey W. Godden, Christophe Vanpouille, Jürgen Bajorath, Michael Bukrinsky   +8 more
openalex   +1 more source

Targeting Glutamine Metabolism Transporter SLC25A22 Enhances CD8+ T‐Cell Function and Anti‐PD‐1 Therapy Efficacy in Cervical Squamous Cell Carcinoma: Integrated Metabolomics, Transcriptomics and T‐Cell‐Incorporated Tumor Organoid Studies

Advanced Science, EarlyView.
Through metabolomic and transcriptomic analyses, a glutamine‐enriched, immunosuppressive microenvironment is identified in cervical squamous cell carcinoma (CSCC), highlighting the glutamine transporter SLC25A22 as a key regulator of glutamine metabolism, immune checkpoint activation, and CD8+ T‐cell cytotoxicity.
Tingting Ren, Junjun Qiu, Fanghua Chen, Qian Jiang, Qinqin Liu, Tong Wu, Hua Jiang, Keqin Hua   +7 more
wiley   +1 more source

Engineered exosomes: a promising drug delivery platform with therapeutic potential. [PDF]

Front Mol Biosci
Schwarz G, Ren X, Xie W, Guo H, Jiang Y, Zhang J.   +5 more
europepmc   +1 more source

Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity

Advanced Science, EarlyView.
Novel quaternary ammonium salt‐linked STING agonist ADC demonstrates high potency, stability, enhanced solubility, and reduced off‐target toxicity, potently activating the STING pathway in the tumor microenvironment through the synergistic action of the Fab and Fc regions of antibodies (activity switch‐on) while exhibiting ≈20 fold lower activity in ...
Yu Long, Borui Tang, Fei Xie, Lianqi Liu, Yangyihua Zhou, Jingwen Dong, Jianfeng Wang, Cuicui Sun, Yuting Wang, Ruoqi Li, Na Zhang, Liping Li, Longlong Luo, Junhai Xiao, Wu Zhong, Dian Xiao, Hongbin Deng, Xinbo Zhou   +17 more
wiley   +1 more source

Examination of the lung and lymphoid tissue mRNA transcriptome response in dairy calves following experimental challenge with bovine alphaherpesvirus one (BoHV-1). [PDF]

PLoS One
O'Donoghue S, Earley B, Johnston D, Finnie MS, Cosby SL, Lemon K, McMenamy MJ, Taylor JF, Kim JW, Morris DW, Waters SM.   +10 more
europepmc   +1 more source

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation

Advanced Science, EarlyView.
This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang, Jiayue Liu, Min Zhang, Juan Yang, Peihan Lian, Xiu Cheng, Jianhua Qin   +6 more
wiley   +1 more source

Beyond Infection: The Role of Secreted Viral Proteins in Pathogenesis, Disease Severity and Diagnostic Applications. [PDF]

Cells
Herrera-Moro Huitron L, Cruz-Holguin VJ, Ulloa-Aguilar JM, De Jesús-González LA, Osuna-Ramos JF, Guzmán-Huerta M, de León-Bautista MP, León-Reyes G, García-Cordero J, Cedillo-Barrón L, Cerna-Cortes JF, León-Juárez M.   +11 more
europepmc   +1 more source

Mercaptophenylboronic Acid‐Mediated Nanozyme Immunochromatographic Assay for Simultaneous Detection of Respiratory Bacteria and Virus

Advanced Science, EarlyView.
This study developes a universal colorimetric ICA platform that integrates broad‐spectrum recognition by 4‐mercaptophenylboronic acid with dual signal enhancement—both colorimetric and catalytic—mediated by a biomimetic magnetic nanozyme. This platform, for the first time, enables simple, convenient, ultrasensitive, and simultaneous screening of ...
Qing Yu, Jiaxuan Li, Shuai Zheng, Yajin Hu, Benshun Tian, Meirou Lu, Bing Gu, Chongwen Wang   +7 more
wiley   +1 more source

Validated Methods for Inactivation of Tick-Borne Encephalitis Virus Compatible with Immune-Based and Enzymatic Downstream Analyses. [PDF]

Viruses
Leoni S, Leib SL, Summermatter K, Grandgirard D.   +3 more
europepmc   +1 more source

Amino Acid Substitution at Position 95 in Rabies Virus Matrix Protein Affects Viral Pathogenicity

, 2011
Naoto Ito, Tetsuo Mita, Kenta Shimizu, Yuki Ito, Tatsunori Masatani, Keisuke Nakagawa, Satoko Yamaoka, Masako Abe, Kota Okadera, Nobuyuki Minamoto, Makoto Sugiyama   +10 more
openalex   +2 more sources