Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang +8 more
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Detection and genetic characterization of equine viruses in Sweden using viral metagenomics. [PDF]
Blomström AL, Källse A, Riihimäki M.
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The Human Virome: Viral Metagenomics, Relations with Human Diseases, and Therapeutic Applications. [PDF]
Bai GH, Lin SC, Hsu YH, Chen SY.
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ssRNA bacteriophage metagenomes reveal a diverse set of novel protein families
Abstract The bacteriophages with single‐stranded RNA (ssRNA) genomes (class Leviviricetes) are among the simplest known viruses that encode only three core proteins: a receptor‐binding protein, a capsid protein, and an RNA‐dependent RNA polymerase. The number of isolated ssRNA phages has remained very low, but the accumulating RNA metagenome data have ...
Jānis Rūmnieks +3 more
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Viral Metagenomics of the Bharal (<i>Pseudois nayaur</i>) within the Qinghai-Tibet Plateau Revealed Diverse Viruses. [PDF]
Zhang E +10 more
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Viral metagenomics reveals two novel anelloviruses in feces of experimental rats. [PDF]
Ning SY +4 more
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Wastewater treatment plant 16S rRNA sequencing data was used to create simulated read sets of known species composition and relative abundances. These sequence sets were used to optimize current 16S metabarcoding analysis pipelines for the complexity of municipal wastewater samples.
Joe Berta +3 more
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Viral metagenomics reveals diverse viruses in the fecal samples of children with acute respiratory infection. [PDF]
Xu P +6 more
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Contamination Issue in Viral Metagenomics: Problems, Solutions, and Clinical Perspectives. [PDF]
Jurasz H, Pawłowski T, Perlejewski K.
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I propose a ‘genome‐first’ framework to collapse the phenotypic bottleneck in bioinput discovery. By integrating multi‐layered genome mining and reverse ecology, this paradigm enables the rational design of stable synthetic microbial communities for a data‐driven and sustainable agricultural bioeconomy.
Osiel Silva Gonçalves
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