Results 31 to 40 of about 52,903 (224)

Infectious diseases and autoimmunity [PDF]

, 2011
Introduction: Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the ...
Deidda, Silvia, Delitala, Giuseppe, Delogu, Lucia Gemma, Manetti, Roberto   +3 more
core   +1 more source

TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders [PDF]

, 2008
Aicardi-Goutieres syndrome (AGS) is an unusual condition that clinically mimics a congenital viral infection. Several genes have recently been implicated in the aetiology of this disorder. One of these genes encodes the DNA exonuclease TREX1. Recent work
Aicardi, Akira, Alderton, Alderton, Bartek, Bartkova, Brennan, Brucet, Chen, Chowdhury, Crow, Crow, de Silva, DiTullio, Driscoll, Gasser, Griffith, Griffiths, Höss, Jazayeri, Kawai, Lee-Kirsch, Lee-Kirsch, Lieberman, Lieberman, Lindahl, Lindahl, Liu, Liu, Liu, Mark O’Driscoll, Martinvalet, Mazur, Mazur, Morita, Napirei, O’Driscoll, O’Driscoll, Qiu, Raulet, Rhodes, Rice, Richards, Shevelev, Stiff, Stiff, Takaoka, Tran, Tsukumo, Vyse, Walport, Yang, Yasutomo, Zou, Zou   +54 more
core   +1 more source

In vivo delivery of adenoviral vector containing interleukin-17 receptor a reduces cardiac remodeling and improves myocardial function in viral myocarditis leading to dilated cardiomyopathy. [PDF]

PLoS ONE, 2013
Th17 cells have been implicated in the pathogenesis of myocarditis. Interleukin (IL)-17A produced by Th17 cells is dispensable for viral myocarditis but essential for the progression to dilated cardiomyopathy (DCM).
Yuquan Xie, Minghui Li, Xinggang Wang, Xian Zhang, Tianqing Peng, Yingzhen Yang, Yunzeng Zou, Junbo Ge, Haozhu Chen, Ruizhen Chen   +9 more
doaj   +1 more source

Comparison of Multisystem Inflammatory Syndrome in Children–Related Myocarditis, Classic Viral Myocarditis, and COVID‐19 Vaccine‐Related Myocarditis in Children

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Although rare, classic viral myocarditis in the pediatric population is a disease that carries significant morbidity and mortality. Since 2020, myocarditis has been a common component of multisystem inflammatory syndrome in children (MIS‐C ...
Trisha Patel, Michael Kelleman, Zachary West, Andrew Peter, Matthew Dove, Arene Butto, Matthew E. Oster   +6 more
doaj   +1 more source

Are there functional consequences of a reduction in selenium intake in UK subjects? [PDF]

, 2004
Dietary Se levels in the UK have fallen over the last 20 years and recent surveys indicate that average Se intakes are 30-40 microg/d, which is well below the current UK reference nutrient intake for adult men (75 microg/d) or women (60 microg/d ...
Anne McArdle, Beck, Bonomini, Broome, Burk, C. Anthony Hart, Caroline S. Broome, Francis McArdle, Gasparian, Ge, Malcolm J. Jackson, Olivieri, Peretz, Stephanie A. Dillon   +13 more
core   +1 more source

Astrocyte Apoptosis and HIV Replication Are Modulated in Host Cells Coinfected with Trypanosoma cruzi [PDF]

, 2017
The protozoan Trypanosoma cruzi is the etiological agent of Chagas disease. In immunosuppressed individuals, as it occurs in the coinfection with human immunodeficiency virus (HIV), the central nervous system may be affected. In this regard, reactivation
Burgos, Juan Miguel, Leguizamon, Maria Susana, Ojeda, Diego Sebastian, Pascuale, Carla Antonela, Quarleri, Jorge Fabian, Urquiza, Javier Mariano   +5 more
core   +1 more source

Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group. [PDF]

, 2017
Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse ...
Abdallah, K., Anderson, J., Andrews, S., Arrindell, D., Ballesteros, J., Bingham, C. O., Boyer, J., Brogdon, C., Chen, D., Chonzi, D., Cotarla, I., Cunha, R., Dadu, R., Davies, M., Dawson, M., Diab, A., Dicker, Adam, Eifler, L., Ernstoff, M. S., Ferguson, A., Ferlini, C., Frankel, S., Go, W., Gochett, C., Goldberg, J., Goncalves, P., Goswami, T., Gregory, N., Gulley, J. L., Hamad, L., Hayreh, V., Helie, N., Holmes, W., Hsu, J. Y., Ibrahim, R., Kaufman, H. L., Kim, S., Lacouture, M. E., Lambotte, O., Larocca, C., LeBoeuf, N. R., Lehman, K., Lenihan, D., Ley-Acosta, S., Luke, J., McClure, J., Michelon, E., Nakamura, M., Onofrei, C., Patel, K., Piperdi, B., Puzanov, I., Rasheed, Z., Reshef, D., Riemer, J., Robert, C., Sarkeshik, M., Saylors, A., Schreiber, J., Shafer-Weaver, K., Shannon, V., Sharfman, W., Sharma, R., Sharon, E., Sherry, R., Silk, A. W., Simonson, C., Skondra, D., Suarez-Almazor, M. E., Thomas, C., Thompson, J. A., Trehu, E., Tresnan, D., Turner, M., Wang, Y., Wariabharaj, D., Waxman, I., Wiley, K., Wood, L., Zhang, L., Zheng, P.   +80 more
core   +2 more sources

TRIM18 is a critical regulator of viral myocarditis and organ inflammation

Journal of Biomedical Science, 2022
Background Infections by viruses including severe acute respiratory syndrome coronavirus 2 could cause organ inflammations such as myocarditis, pneumonia and encephalitis.
Mingli Fang, Ao Zhang, Yong Du, Wenting Lu, Junying Wang, Laurie J. Minze, Timothy C. Cox, Xian Chang Li, Junji Xing, Zhiqiang Zhang   +9 more
doaj   +1 more source

Features of Myocarditis: Morphological Differential Diagnosis in Post-COVID-19 Children

Diagnostics, 2023
Myocarditis is characterized by dysfunction and destruction of cardiomyocytes, infiltrative inflammation, and development of fibrosis. Late diagnosis of myocarditis has been a serious global health problem, especially due to the spread of a new ...
Vadim Karev, Anastasia Ya Starshinova, Anzhela Glushkova, Dmitry Kudlay, Anna Starshinova   +4 more
doaj   +1 more source

Cell Specific Coxsackievirus B3 Replication [PDF]

, 2014
Myocarditis is an inflammatory disease caused by viral infection. Different subpopulations of leukocytes enter the cardiac tissue and lead to severe cardiac inflammation associated with myocyte loss and remodeling.
Blankenberg, Stefan, Klingel, Karin, Li, Jia, Lindner, Diana, Savvatis, Konstantinos, Tschöpe, Carsten, Westermann, Dirk   +6 more
core   +1 more source