Appendectomy Mitigates Coxsackievirus B3−Induced Viral Myocarditis [PDF]
Viruses, 2023 Appendix has a distinct abundance of lymphatic cells and serves as a reservoir of microbiota which helps to replenish the large intestine with healthy flora.
Chengrui Niu, Wei Xu, Sidong Xiong
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Suppression of Calcium Influx Reduces Coxsackievirus B3 Lethality With Elevated Interferon Beta Responses in Mice. [PDF]
J Med VirolABSTRACT The disease course of severe enterovirus (EV) infection with hepatic necrosis is usually fulminant and fatal. Coxsackievirus (CVB3) is the emerging and important serotype of newborn EV inducing hepatic necrosis. Calcium (Ca2+) regulates host immunity, type I interferon (IFN‐I), and viral infections.
Hsiao YL, Hung CH, Yeh MT, Chen SH.
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N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication [PDF]
VirusesEnteroviruses such as coxsackievirus B3 are identified as a common cause of viral myocarditis, but the potential mechanism of its replication and pathogenesis are largely unknown.
Hainian Zhao +9 more
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Coxsackievirus B3—Its Potential as an Oncolytic Virus [PDF]
Viruses, 2021 Oncolytic virotherapy represents one of the most advanced strategies to treat otherwise untreatable types of cancer. Despite encouraging developments in recent years, the limited fraction of patients responding to therapy has demonstrated the need to ...
Anja Geisler +4 more
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Inhibitory Effect of Sirtuin6 on EndMT by Regulating Oxidative Stress and Autophagy in Coxsackievirus B3-Induced Cardiac Endothelial Cells. [PDF]
Immun Inflamm DisThis study found that Sirtuin 6 can inhibit CVB3‐induced endothelial‐to‐mesenchymal transition. This protective effect involves the regulation of oxidative stress and autophagy, providing new experimental evidence for elucidating the pathological mechanisms of viral myocarditis.
Yang Z +6 more
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ROS-Mediated Necroptosis Promotes Coxsackievirus B3 Replication and Myocardial Injury [PDF]
MicroorganismsCoxsackievirus B3 (CVB3) is a primary causative agent of viral myocarditis (VMC), which can lead to both acute and chronic cardiac inflammation accompanied by progressive heart failure and arrhythmias.
Junbo Huang +9 more
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Comprehensive profiling of neutralizing polyclonal sera targeting coxsackievirus B3 [PDF]
Nature Communications, 2023 Despite their fundamental role in resolving viral infections, our understanding of how polyclonal neutralizing antibody responses target non-enveloped viruses remains limited.
Beatriz Álvarez-Rodríguez +2 more
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Ubiquitination is required for effective replication of coxsackievirus B3. [PDF]
PLoS ONE, 2008 BACKGROUND: Protein ubiquitination and/or degradation by the ubiquitin/proteasome system (UPS) have been recognized as critical mechanisms in the regulation of numerous essential cellular functions.
Xiaoning Si +5 more
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Targeting Viperin prevents coxsackievirus B3-induced acute heart failure [PDF]
Cell DiscoveryCoxsackievirus B3 (CVB3)-induced acute heart failure (AHF) is a common cause of cardiogenic death in young- and middle-aged people. However, the key molecular events linking CVB3 to AHF remain largely unknown, resulting in a lack of targeted therapy ...
Yukang Yuan +21 more
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Coxsackievirus B3 Activates Macrophages Independently of CAR-Mediated Viral Entry [PDF]
VirusesEnteroviruses are a genus of small RNA viruses that are responsible for approximately one billion global infections annually. These infections range in severity from the common cold and flu-like symptoms to more severe diseases, such as viral myocarditis,
Yasir Mohamud +5 more
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