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Coxsackievirus B3 Activates Macrophages Independently of CAR-Mediated Viral Entry [PDF]

Viruses
Enteroviruses are a genus of small RNA viruses that are responsible for approximately one billion global infections annually. These infections range in severity from the common cold and flu-like symptoms to more severe diseases, such as viral myocarditis,
Yasir Mohamud, Jingfei Carly Lin, Sinwoo Wendy Hwang, Amirhossein Bahreyni, Zhihan Claire Wang, Honglin Luo   +5 more
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Appendectomy Mitigates Coxsackievirus B3−Induced Viral Myocarditis [PDF]

Viruses, 2023
Appendix has a distinct abundance of lymphatic cells and serves as a reservoir of microbiota which helps to replenish the large intestine with healthy flora.
Chengrui Niu, Wei Xu, Sidong Xiong
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N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication [PDF]

Viruses
Enteroviruses such as coxsackievirus B3 are identified as a common cause of viral myocarditis, but the potential mechanism of its replication and pathogenesis are largely unknown.
Hainian Zhao, Zhiyun Gao, Jiawen Sun, Hongxiu Qiao, Yan Zhao, Yan Cui, Baoxin Zhao, Weijie Wang, Sandra Chiu, Xia Chuai   +9 more
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Abietic acid targets RAN to restrict coxsackievirus B3 infection [PDF]

Frontiers in Microbiology
Coxsackievirus B3 (CVB3) represents a major etiological factor of viral myocarditis (VMC). It frequently results in the damage of the heart and even heart failure, but there are few effective treatment measures that can be used clinically. In this paper,
Junbo Huang, Qing Song, Yanjun Di, Zhiyun Cheng, Zhaocheng Yang, Xibo Lin, Kaiyuan Hunag, Haoyi Zhan, Lijuan Xie, Jieqing Liu, Lei Tong   +10 more
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ROS-Mediated Necroptosis Promotes Coxsackievirus B3 Replication and Myocardial Injury [PDF]

Microorganisms
Coxsackievirus B3 (CVB3) is a primary causative agent of viral myocarditis (VMC), which can lead to both acute and chronic cardiac inflammation accompanied by progressive heart failure and arrhythmias.
Junbo Huang, Yanjun Di, Qing Song, Zhiyun Cheng, Hao Wu, Mei Wu, Minjian He, Genrui Zhang, Fucai Wang, Lei Tong   +9 more
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Comprehensive profiling of neutralizing polyclonal sera targeting coxsackievirus B3 [PDF]

Nature Communications, 2023
Despite their fundamental role in resolving viral infections, our understanding of how polyclonal neutralizing antibody responses target non-enveloped viruses remains limited.
Beatriz Álvarez-Rodríguez, Javier Buceta, Ron Geller   +2 more
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Targeting Viperin prevents coxsackievirus B3-induced acute heart failure [PDF]

Cell Discovery
Coxsackievirus B3 (CVB3)-induced acute heart failure (AHF) is a common cause of cardiogenic death in young- and middle-aged people. However, the key molecular events linking CVB3 to AHF remain largely unknown, resulting in a lack of targeted therapy ...
Yukang Yuan, Liping Qian, Ying Miao, Qun Cui, Ting Cao, Yong Yu, Tingting Zhang, Qian Zhao, Renxia Zhang, Tengfei Ren, Yibo Zuo, Qian Du, Caixia Qiao, Qiuyu Wu, Zhijin Zheng, Minqi Li, Y. Eugene Chinn, Wei Xu, Tianqing Peng, Ruizhen Chen, Sidong Xiong, Hui Zheng   +21 more
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Mt10-CVB3 Vaccine Virus Protects against CVB4 Infection by Inducing Cross-Reactive, Antigen-Specific Immune Responses

Microorganisms, 2021
Group B coxsackieviruses (CVB) containing six serotypes, B1–B6, affect various organs, and multiple serotypes can induce similar diseases such as myocarditis and pancreatitis.
Ninaad Lasrado, Rajkumar Arumugam, Mahima T. Rasquinha, Meghna Sur, David Steffen, Jay Reddy   +5 more
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A neonatal case of coxsackievirus B3 vertical infection with symptoms of hemophagocytic lymphohistiocytosis

IDCases, 2020
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of excessive immune activation that most commonly affects infants. We report the case of a term female neonate with HLH associated with coxsackievirus B3 Infection.
Yasuhiro Miyoshi, Sachika Yoshioka, Hirokazu Gosho, Shoichi Miyazoe, Hideyo Suenaga, Mikihiro Aoki, Kunio Hashimoto   +6 more
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Crystal structure of a highly conserved enteroviral 5′ cloverleaf RNA replication element

Nature Communications, 2023
A cloverleaf-like RNA domain within the enterovirus genome is essential for replication. Here, the authors determine the 1.9 Å resolution crystal structure of such RNA from coxsackievirus B3 – a model enterovirus to study many other human viruses.
Naba K. Das, Nele M. Hollmann, Jeff Vogt, Spiridon E. Sevdalis, Hasan A. Banna, Manju Ojha, Deepak Koirala   +6 more
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