Coxsackievirus B3 Activates Macrophages Independently of CAR-Mediated Viral Entry [PDF]
VirusesEnteroviruses are a genus of small RNA viruses that are responsible for approximately one billion global infections annually. These infections range in severity from the common cold and flu-like symptoms to more severe diseases, such as viral myocarditis,
Yasir Mohamud +5 more
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Common Chemical Plasticizer Di(2-Ethhylhexyl) Phthalate Exposure Exacerbates Coxsackievirus B3 Infection [PDF]
VirusesDi(2-ethhylhexyl) phthalate (DEHP) is a common plastic rubberizer. DEHP leaches from plastic matrices and is under increasing scrutiny as numerous studies have linked it to negative human health manifestations. Coxsackievirus B3 (CVB) is a human pathogen
Ramina Kordbacheh +9 more
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Inhibitory Effect of Sirtuin6 on EndMT by Regulating Oxidative Stress and Autophagy in Coxsackievirus B3-Induced Cardiac Endothelial Cells. [PDF]
Immun Inflamm DisThis study found that Sirtuin 6 can inhibit CVB3‐induced endothelial‐to‐mesenchymal transition. This protective effect involves the regulation of oxidative stress and autophagy, providing new experimental evidence for elucidating the pathological mechanisms of viral myocarditis.
Yang Z +6 more
europepmc +2 more sources
Microorganisms, 2021 Group B coxsackieviruses (CVB) containing six serotypes, B1–B6, affect various organs, and multiple serotypes can induce similar diseases such as myocarditis and pancreatitis.
Ninaad Lasrado +5 more
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Update on coxsackievirus B3 myocarditis [PDF]
Current Opinion in Rheumatology, 2012 To present recent findings on the pathogenesis of coxsackievirus B3 (CVB3) myocarditis based on animal models, with a focus on the role of T helper (Th) immune responses in disease progression.Acute CVB3 myocarditis is known to be increased by Th1 immune responses, but recent findings indicate that Th1-type immunity protects against acute myocarditis ...
DeLisa, Fairweather +2 more
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IDCases, 2020 Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of excessive immune activation that most commonly affects infants. We report the case of a term female neonate with HLH associated with coxsackievirus B3 Infection.
Yasuhiro Miyoshi +6 more
doaj +1 more source
Myocarditis, disseminated infection, and early viral persistence following experimental coxsackievirus B infection of cynomolgus monkeys. [PDF]
, 2013 Coxsackievirus B (CVB) infection is a common cause of acute viral myocarditis. The clinical presentation of myocarditis caused by this enterovirus is highly variable, ranging from mildly symptoms to complete hemodynamic collapse.
Blanchard, James +7 more
core +6 more sources
Crystal structure of a highly conserved enteroviral 5′ cloverleaf RNA replication element
Nature Communications, 2023 A cloverleaf-like RNA domain within the enterovirus genome is essential for replication. Here, the authors determine the 1.9 Å resolution crystal structure of such RNA from coxsackievirus B3 – a model enterovirus to study many other human viruses.
Naba K. Das +6 more
doaj +1 more source
Coxsackievirus B3-associated panuveitis. [PDF]
British Journal of Ophthalmology, 1993 A 29-year-old woman suffered from headaches, diarrhoea, and high grade fever followed by a unilateral retinal vasculitis, papillitis, and chorioretinitis. Abnormal electrocardiographic findings and antibody titre dynamics strongly suggested a coxsackievirus B3 infection.
W, Förster, A A, Bialasiewicz, H, Busse
openaire +2 more sources
Modeling viral infectious diseases and development of antiviral therapies using human induced pluripotent stem cell-derived systems [PDF]
, 2015 The recent biotechnology breakthrough of cell reprogramming and generation of induced pluripotent stem cells (iPSCs), which has revolutionized the approaches to study the mechanisms of human diseases and to test new drugs, can be exploited to generate ...
Barzon, Luisa +6 more
core +4 more sources