Results 21 to 30 of about 8,213 (208)

Common Chemical Plasticizer Di(2-Ethhylhexyl) Phthalate Exposure Exacerbates Coxsackievirus B3 Infection [PDF]

Viruses
Di(2-ethhylhexyl) phthalate (DEHP) is a common plastic rubberizer. DEHP leaches from plastic matrices and is under increasing scrutiny as numerous studies have linked it to negative human health manifestations. Coxsackievirus B3 (CVB) is a human pathogen
Ramina Kordbacheh, Madelyn Ashley, William D. Cutts, Taryn E. Keyzer, Shruti Chatterjee, Tyler J. Altman, Natalie G. Alexander, Timothy E. Sparer, Brandon J. Kim, Jon Sin   +9 more
doaj   +2 more sources

Extremely Low Organ Toxicity and Strong Antitumor Activity of miR-34-Regulated Oncolytic Coxsackievirus B3

Molecular Therapy: Oncolytics, 2019
Oncolytic virotherapies have emerged as new modalities for cancer treatment. We previously reported that coxsackievirus B3 (CVB3) is a novel oncolytic virus (OV) with a strong ability to lyse human non-small cell lung cancer cells; however, its non ...
Yang Jia, Shohei Miyamoto, Yasushi Soda, Yuto Takishima, Miyako Sagara, Jiyuan Liao, Lisa Hirose, Yasuki Hijikata, Yoshie Miura, Kenichiro Hara, Atsufumi Iwanaga, Yasunori Ota, Kenzaburo Tani   +12 more
doaj   +2 more sources

Identification of Drug Repurposing Candidates for Coxsackievirus B3 Infection in iPSC-Derived Brain-like Endothelial Cells. [PDF]

Int J Mol Sci
The enterovirus Coxsackievirus B3 causes a range of serious health problems, including aseptic meningitis, myocarditis, and pancreatitis. Currently, Coxsackievirus B3 has no targeted antiviral treatments or vaccines, leaving supportive care as the ...
Wood JF, Vergis JM, Imami AS, Ryan WG, Sin JJ, Kim BJ, Schiefer IT, McCullumsmith RE.   +7 more
europepmc   +2 more sources

Mt10-CVB3 Vaccine Virus Protects against CVB4 Infection by Inducing Cross-Reactive, Antigen-Specific Immune Responses

Microorganisms, 2021
Group B coxsackieviruses (CVB) containing six serotypes, B1–B6, affect various organs, and multiple serotypes can induce similar diseases such as myocarditis and pancreatitis.
Ninaad Lasrado, Rajkumar Arumugam, Mahima T. Rasquinha, Meghna Sur, David Steffen, Jay Reddy   +5 more
doaj   +1 more source

A neonatal case of coxsackievirus B3 vertical infection with symptoms of hemophagocytic lymphohistiocytosis

IDCases, 2020
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of excessive immune activation that most commonly affects infants. We report the case of a term female neonate with HLH associated with coxsackievirus B3 Infection.
Yasuhiro Miyoshi, Sachika Yoshioka, Hirokazu Gosho, Shoichi Miyazoe, Hideyo Suenaga, Mikihiro Aoki, Kunio Hashimoto   +6 more
doaj   +1 more source

Update on coxsackievirus B3 myocarditis [PDF]

Current Opinion in Rheumatology, 2012
To present recent findings on the pathogenesis of coxsackievirus B3 (CVB3) myocarditis based on animal models, with a focus on the role of T helper (Th) immune responses in disease progression.Acute CVB3 myocarditis is known to be increased by Th1 immune responses, but recent findings indicate that Th1-type immunity protects against acute myocarditis ...
DeLisa, Fairweather, Katelyn A, Stafford, Yoon K, Sung   +2 more
openaire   +2 more sources

Crystal structure of a highly conserved enteroviral 5′ cloverleaf RNA replication element

Nature Communications, 2023
A cloverleaf-like RNA domain within the enterovirus genome is essential for replication. Here, the authors determine the 1.9 Å resolution crystal structure of such RNA from coxsackievirus B3 – a model enterovirus to study many other human viruses.
Naba K. Das, Nele M. Hollmann, Jeff Vogt, Spiridon E. Sevdalis, Hasan A. Banna, Manju Ojha, Deepak Koirala   +6 more
doaj   +1 more source

CVB3 Inhibits NLRP3 Inflammasome Activation by Suppressing NF-κB Pathway and ROS Production in LPS-Induced Macrophages

Viruses, 2023
Inflammasomes are cytosolic sensors of pathogens. Their activation can lead to the induction of caspase-1-mediated inflammatory responses and the release of several proinflammatory cytokines, including IL-1β. There is a complex relationship between viral
Yanqi Wang, Zhirong Sun, Hongkai Zhang, Yahui Song, Yi Wang, Wei Xu, Min Li   +6 more
doaj   +1 more source

Coxsackievirus B3, Shandong Province, China, 1990–2010

Emerging Infectious Diseases, 2012
To determine the cause of a 2008 outbreak of aseptic meningitis in Shandong Province, China, we analyzed samples from outbreak patients and coxsackievirus B3 samples collected during 1990–2010 surveillance. The cause of the outbreak was coxsackievirus B3,
Zexin Tao, Yanyan Song, Yan Li, Yao Liu, Ping Jiang, Xiaojuan Lin, Guifang Liu, Lizhi Song, Haiyan Wang, Aiqiang Xu   +9 more
doaj   +1 more source

Enhancement of coxsackievirus B3 infection by antibody to a different coxsackievirus strain [PDF]

Journal of General Virology, 2002
Group B coxsackieviruses (CVBs) are a major cause of viral myocarditis and pancreatitis in humans and produce a similar pattern of disease in inbred strains of mice. As there are six strains of CVBs, individuals can be infected with multiple serotypes.
Jaskamal, Girn, Mojgan, Kavoosi, Janet, Chantler   +2 more
openaire   +2 more sources