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2016
Cancer immunotherapy is a rapidly evolving field and the search for appropriate targets to come up with robust immunotherapeutic strategies for the treatment of cancers is a continuous process. Viral-like proteins are known to have an important role in the oncogenesis and their potential as cancer therapeutic targets is yet to be completely explored ...
Keith L. Knutson, Lavakumar Karyampudi
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Cancer immunotherapy is a rapidly evolving field and the search for appropriate targets to come up with robust immunotherapeutic strategies for the treatment of cancers is a continuous process. Viral-like proteins are known to have an important role in the oncogenesis and their potential as cancer therapeutic targets is yet to be completely explored ...
Keith L. Knutson, Lavakumar Karyampudi
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Trafficking of Viral Membrane Proteins
2005Many viruses express membrane proteins. For enveloped viruses in particular, membrane proteins are frequently structural components of the virus that mediate the essential tasks of receptor recognition and membrane fusion. The functional activities of these proteins require that they are sorted correctly in infected cells.
Rahel Byland, Mark Marsh
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Viral chemokine-binding proteins
Journal of Leukocyte Biology, 2002AbstractThe chemokines are a large family of small signaling proteins that bind to G-protein-coupled receptors (GPCRs) on target cells and mediate the directional migration of immune cells into sites of infection or inflammation. The large DNA viruses, particularly the poxviruses and herpesviruses, have evolved several mechanisms to corrupt the normal ...
Grant McFadden, Bruce T. Seet
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Myristoylation of viral and bacterial proteins
Trends in Microbiology, 2004Abstract Myristoylation, the N-terminal attachment of a myristoyl lipid anchor to a glycine residue, can reversibly direct protein–membrane and protein–protein interactions. Apart from two entomopoxviruses, viruses and bacteria usually lack the enzyme N-myristoyltransferase (NMT) that is required for this modification, and their proteins are ...
Frank Eisenhaber, Sebastian Maurer-Stroh
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Synthesis of Tacaribe viral proteins
Virology, 1979Abstract The synthesis of Tacaribe virus-specific proteins in infected BHK-21 cells has been analyzed by polyacrylamide slab gel electrophoresis and fluorography. The two major structural polypeptides of the virion were observed above the host cell background by pulse labeling with amino acid or sugar precursors.
Richard W. Compans +2 more
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1995
Since the discovery of the human immunodeficiency viruses types 1 (HIV-1) and 2 (HIV-2) as the causative agents of acquired immunodeficiency syndrome (AIDS) (Barre-Sinoussi et al. 1983; Clavel et al. 1987; Papovic et al. 1984) and the isolation of related lentiviruses from several species of Old World monkeys, much has been learned about their biology ...
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Since the discovery of the human immunodeficiency viruses types 1 (HIV-1) and 2 (HIV-2) as the causative agents of acquired immunodeficiency syndrome (AIDS) (Barre-Sinoussi et al. 1983; Clavel et al. 1987; Papovic et al. 1984) and the isolation of related lentiviruses from several species of Old World monkeys, much has been learned about their biology ...
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Identification of Immunoreactive Viral Proteins
2003Several diagnostic tools are available for the identification of acute and latent viral infections. Although newly developed nucleic acid amplification methods, such as the polymerase chain reaction (PCR), have proved to be very useful diagnostic procedures, conventional methods, such as cell culture and serology, still play an important role in viral ...
Bodo Plachter +2 more
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Vaccination with Purified Viral Proteins [PDF]
, 1972 Inactivated viral vaccines currently in use consist, in most cases, of rather impure suspensions of virus particles and soluble antigens. It has been demonstrated that not all antigens of a given virus are required to induce antibody responses leading to protection.
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Viral and Non-Viral Approaches for Transient Delivery of mRNA and Proteins
Current Gene Therapy, 2011The transient delivery of gene products (RNA or proteins) is not a biotechnological invention but rather an evolutionarily conserved process underlying and regulating a variety of biological functions. On the basis of insights into the underlying mechanisms, several viral and cell-based approaches have been developed for the delivery of RNA or proteins.
Axel Schambach +4 more
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Viral protein kinases and protein phosphatases
Pharmacology & Therapeutics, 1993Certain large DNA viruses (e.g. herpesviruses and poxviruses) encode proteins related to cellular protein-serine/threonine kinases, and Hepatitis B virus and vesicular stomatitis virus may encode structurally different protein kinases. Other viruses activate cellular protein kinases, e.g. interferon-induced eukaryotic initiation factor-2 kinase, growth
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