Results 41 to 50 of about 1,214,456 (357)

USP7 manipulation by viral proteins

open access: yesVirus Research, 2020
Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme (DUB) that plays critical roles in the regulation of many cellular processes including epigenetics, tumour suppression, oncogenesis, DNA damage response, immunity and viral infection. USP7 was the first DUB associated with viral infection.
Anna, Bojagora, Vivian, Saridakis
openaire   +2 more sources

Grass Carp Reovirus (GCRV) Giving Its All to Suppress IFN Production by Countering MAVS Signaling Transduction

open access: yesFrontiers in Immunology, 2020
Viruses typically target host RIG-I-like receptors (RLRs), a group of key factors involved in interferon (IFN) production, to enhance viral infection.
Long-Feng Lu   +17 more
doaj   +1 more source

Antigenic properties of sARs-CoV-2/human/RUs/nsk-FRCFtM-1/2020 coronavirus isolate from a patient in novosibirsk

open access: yesЖурнал инфектологии, 2020
Objective: isolation of coronavirus SARS-CoV-2 from clinical sample of patient with COVID-19 in Novosibirsk; obtaining a purified and inactivated viral antigen and study of its antigenic properties.
A. A. Chepurnov   +9 more
doaj   +1 more source

SUMOylation in Viral Replication and Antiviral Defense

open access: yesAdvanced Science, 2022
SUMOylation is a ubiquitination‐like post‐translational modification that plays an essential role in the regulation of protein function. Recent studies have shown that proteins from both RNA and DNA virus families can be modified by SUMO conjugation ...
Yao Fan   +10 more
doaj   +1 more source

Mimicry between proteins of human and avian influenza viruses and host immune system proteins

open access: yesAIMS Allergy and Immunology, 2021
Viral infection can lead to dangerous and severe manifestations associated with immunosuppression and a cytokine storm. The last is typical for influenza A virus infection of H1N1 subtype, when the level of cytokines in the peripheral blood is ...
Irina N. Zhilinskaya   +2 more
doaj   +1 more source

The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1) [PDF]

open access: yes, 2016
Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting
Boutell, Chris   +7 more
core   +1 more source

Viral Organization of Human Proteins

open access: yesPLoS ONE, 2010
Although maps of intracellular interactions are increasingly well characterized, little is known about large-scale maps of host-pathogen protein interactions. The investigation of host-pathogen interactions can reveal features of pathogenesis and provide a foundation for the development of drugs and disease prevention strategies.
Stefan Wuchty   +2 more
openaire   +4 more sources

Identification of a Plum pox virus CI-Interacting Protein from Chloroplast That Has a Negative Effect in Virus Infection

open access: yesMolecular Plant-Microbe Interactions, 2006
The cylindrical inclusion (CI) protein of potyviruses is involved in virus replication and cell-to-cell movement. These two processes should rely on multiple plant-virus interactions; however, little is known about the host factors that are involved in ...
I. Jiménez   +4 more
doaj   +1 more source

Proteomic analysis of Glossina pallidipes salivary gland hypertrophy virus virions for immune intervention in tsetse fly colonies [PDF]

open access: yes, 2010
Many species of tsetse flies (Diptera: Glossinidae) can be infected by a virus that causes salivary gland hypertrophy (SGH). The viruses isolated from Glossina pallidipes (GpSGHV) and Musca somestica (MdSGHV) have recently been sequenced.
Abd-Alla, A.M.M.   +7 more
core   +2 more sources

Unconventional secretion of viral proteins

open access: yesSeminars in Cell & Developmental Biology, 2018
Although largely less numerous and characterized than bacterial secreted effectors, several viral virulence factors are secreted by virus infected cells. However, their mode of secretion only starts to be studied at the molecular level. Several of these viral effectors are secreted using an unconventional secretion pathway, i.e.
Schatz, Malvina   +2 more
openaire   +3 more sources

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