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Regulation of Apoptosis During Porcine Circovirus Type 2 Infection
Frontiers in Microbiology, 2018 Apoptosis, an indispensable innate immune mechanism, regulates cellular homeostasis by removing unnecessary or damaged cells. It contains three signaling pathways: the mitochondria-mediated pathway, the death receptor pathway and the endoplasmic ...
Yuhong Pan +15 more
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Вопросы вирусологии, 2023 Introduction. Kindia tick virus (KITV) is a novel segmented unclassified flavi-like virus of the Flaviviridae family. This virus is associated with ixodes ticks and is potentially pathogenic to humans.
A. A. Gladysheva +3 more
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The Critical Role of Genome Maintenance Proteins in Immune Evasion During Gammaherpesvirus Latency
Frontiers in Microbiology, 2019 Gammaherpesviruses are important pathogens that establish latent infection in their natural host for lifelong persistence. During latency, the viral genome persists in the nucleus of infected cells as a circular episomal element while the viral gene ...
Océane Sorel +2 more
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Safe Functional Inference for Uncharacterized Viral Proteins [PDF]
, 2008 The explosive growth in the number of sequenced genomes has created a flood of protein sequences with unknown structure and function. A routine protocol for functional inference on an input query sequence is based on a database search for homologues ...
Michal Linial, Yaniv Loewenstein
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Going Viral with Fluorescent Proteins [PDF]
Journal of Virology, 2015 ABSTRACT Many longstanding questions about dynamics of virus-cell interactions can be answered by combining fluorescence imaging techniques with fluorescent protein (FP) tagging strategies. Successfully creating a FP fusion with a cellular or viral protein of interest first requires selecting the appropriate FP.
Lindsey M. Costantini, Erik L. Snapp
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Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins. [PDF]
, 2019 The plasma membrane is a site of conflict between host defenses and many viruses. One aspect of this conflict is the host's attempt to eliminate infected cells using innate and adaptive cell-mediated immune mechanisms that recognize features of the ...
Guatelli, John +5 more
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APOBEC3 Proteins in Viral Immunity [PDF]
The Journal of Immunology, 2015 Abstract Apolipoprotein B editing complex 3 family members are cytidine deaminases that play important roles in intrinsic responses to infection by retroviruses and have been implicated in the control of other viruses, such as parvoviruses, herpesviruses, papillomaviruses, hepatitis B virus, and retrotransposons.
Spyridon Stavrou, Susan R. Ross
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USP7 manipulation by viral proteins
Virus Research, 2020 Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme (DUB) that plays critical roles in the regulation of many cellular processes including epigenetics, tumour suppression, oncogenesis, DNA damage response, immunity and viral infection. USP7 was the first DUB associated with viral infection.
Anna Bojagora, Vivian Saridakis
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Viral Proteins as Emerging Cancer Therapeutics [PDF]
Cancers, 2021 Viruses are obligatory intracellular parasites that originated millions of years ago. Viral elements cover almost half of the human genome sequence and have evolved as genetic blueprints in humans. They have existed as endosymbionts as they are largely dependent on host cell metabolism.
Manocha E., Caruso A., Caccuri F.
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Characterization and subcellular localization of Alongshan virus proteins
Frontiers in Microbiology, 2022 Alongshan virus (ALSV) in the Jingmenvirus group within the family Flaviviridae is a newly discovered tick-borne virus associated with human disease, whose genome includes four segments and encodes four structural proteins (VP1a, VP1b, VP2, VP3, and VP4)
Yinghua Zhao +13 more
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