Results 21 to 30 of about 873,504 (263)

APOBEC3 Proteins in Viral Immunity [PDF]

open access: yesThe Journal of Immunology, 2015
Abstract Apolipoprotein B editing complex 3 family members are cytidine deaminases that play important roles in intrinsic responses to infection by retroviruses and have been implicated in the control of other viruses, such as parvoviruses, herpesviruses, papillomaviruses, hepatitis B virus, and retrotransposons.
Spyridon Stavrou, Susan R Ross
openaire   +2 more sources

Viral Hijacking of BET Proteins

open access: yesViruses, 2022
Proteins of the bromodomain and exterminal domain (BET) family mediate critical host functions such as cell proliferation, transcriptional regulation, and the innate immune response, which makes them preferred targets for viruses. These multidomain proteins are best known as transcriptional effectors able to read acetylated histone and non-histone ...
Irene P. Chen, Melanie Ott
openaire   +3 more sources

Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern

open access: yesiScience, 2021
Summary: Hyperimmune immunoglobulin (hCoV-2IG) generated from SARS-CoV-2 convalescent plasma (CP) are under evaluation in clinical trials. Here we explored the antibody epitope repertoire, and virus neutralizing capacity of six hCoV-2IG batches as well ...
Juanjie Tang   +9 more
doaj   +1 more source

CD4+ T Cell Depletion in Human Immunodeficiency Virus (HIV) Infection: Role of Apoptosis

open access: yesViruses, 2011
Human immunodeficiency virus (HIV) infection is principally a mucosal disease and the gastrointestinal (GI) tract is the major site of HIV replication. Loss of CD4+ T cells and systemic immune hyperactivation are the hallmarks of HIV infection.
Angelita Rebollo   +2 more
doaj   +1 more source

Structural Motifs and Spatial Structures of Helicase (NS3) and RNA-dependent RNA-polymerase (NS5) of a Flavi-like Kindia tick virus (unclassified Flaviviridae)

open access: yesВопросы вирусологии, 2023
Introduction. Kindia tick virus (KITV) is a novel segmented unclassified flavi-like virus of the Flaviviridae family. This virus is associated with ixodes ticks and is potentially pathogenic to humans.
A. A. Gladysheva   +3 more
doaj   +1 more source

The Viral Protein Corona Directs Viral Pathogenesis and Amyloid Aggregation

open access: yesNature Communications, 2018
Abstract Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that ...
Kariem Ezzat   +25 more
openaire   +8 more sources

The HTLV-1 Virological Synapse

open access: yesViruses, 2010
Human T-lymphotropic virus-1 (HTLV-1) spreads efficiently between T-cells via a tight and highly organized cell-cell contact known as the virological synapse.
Mohamed Nejmeddine, Charles R.M. Bangham
doaj   +1 more source

Regulation of alphaherpesvirus protein via post-translational phosphorylation

open access: yesVeterinary Research, 2022
An alphaherpesvirus carries dozens of viral proteins in the envelope, tegument and capsid structure, and each protein plays an indispensable role in virus adsorption, invasion, uncoating and release.
Tong Zhou   +18 more
doaj   +1 more source

Characterization and subcellular localization of Alongshan virus proteins

open access: yesFrontiers in Microbiology, 2022
Alongshan virus (ALSV) in the Jingmenvirus group within the family Flaviviridae is a newly discovered tick-borne virus associated with human disease, whose genome includes four segments and encodes four structural proteins (VP1a, VP1b, VP2, VP3, and VP4)
Yinghua Zhao   +13 more
doaj   +1 more source

THE POSSIBLE COLLISIONS IN VIRUS INFECTION IMMUNODIAGNOSTICS AND VACCINATION

open access: yesИнфекция и иммунитет, 2016
Antibodies (Ab), especially natural, display multiple specificity not only due to intrinsic conformational dynamics. With computational analysis the distribution of identical and homologous peptides has been studied in surface proteins from RNA and DNA ...
E. P. Kharchenko
doaj   +1 more source

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