Results 41 to 50 of about 38,667 (276)

Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency.

PLoS Pathogens, 2023
HIV rapidly rebounds after interruption of antiretroviral therapy (ART). HIV-specific CD8+ T cells may act to prevent early events in viral reactivation. However, the presence of viral immune escape mutations may limit the effect of CD8+ T cells on viral
Steffen S Docken, Kevin McCormick, M Betina Pampena, Sadia Samer, Emily Lindemuth, Mykola Pinkevych, Elise G Viox, Yuhuang Wu, Timothy E Schlub, Deborah Cromer, Brandon F Keele, Mirko Paiardini, Michael R Betts, Katharine J Bar, Miles P Davenport   +14 more
doaj   +1 more source

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals. [PDF]

, 2019
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Bale, Michael J, Busch, Michael P, Cox, Bryan, Deeks, Steven G, Hoh, Rebecca, Kearney, Mary F, Kulpa, Deanna A, Lackman-Smith, Carol, Maldarelli, Frank, Ptak, Roger G, Stone, Mars, Subramanian, Krupa, Wiegand, Ann, Wonderlich, Elizabeth R   +13 more
core   +1 more source

Viral suppression and viral rebound among young adults living with HIV in Canada

Medicine, 2018
Describe the prevalence and covariates of viral suppression and subsequent rebound among younger (≤29 years old) compared with older adults.A retrospective clinical cohort study; eligibility criteria: documented HIV infection; resident of Canada; 18 years and over; first antiretroviral regimen comprised of at least 3 individual agents on or after ...
Palmer, Alexis, Gabler, Karyn, Rachlis, Beth, Ding, Erin, Chia, Jason, Bacani, Nic, Bayoumi, Ahmed M., Closson, Kalysha, Klein, Marina, Cooper, Curtis, Burchell, Ann, Walmsley, Sharon, Kaida, Angela, Hogg, Robert   +13 more
openaire   +2 more sources

Multiple imputation approach for interval-censored time to HIV RNA viral rebound within a mixed effects Cox model [PDF]

, 2018
This is the peer reviewed version of the following article: “Alarcón-Soto, Y, Langohr K., Fehér, C., García, F., and Gómez, G. (2018) Multiple imputation approach for interval-censored time to HIV RNA viral rebound within a mixed effects Cox Model ...
Alarcón Soto, Yovaninna, Fehér, C., García Alcaide, Felipe, Gómez Melis, Guadalupe, Langohr, Klaus   +4 more
core   +2 more sources

Latent HIV dynamics and implications for sustained viral suppression in the absence of antiretroviral therapy

Journal of Virus Eradication, 2018
Objectives: The interaction between HIV and the immune system gives rise to a complex dynamical system. We therefore investigate whether delayed viral rebound after antiretroviral therapy (ART) interruption (ATI) may be due to an individual's viral ...
John M. Murray
doaj   +1 more source

Early and Highly Suppressive ART are Main Factors Associated with Low Viral Reservoir in European Perinatally HIV Infected Children [PDF]

, 2018
BACKGROUND: Future strategies aiming to achieve HIV-1 remission are likely to target individuals with small reservoir size. SETTING: We retrospectively investigated factors associated with HIV-1 DNA levels in European, perinatally HIV-infected ...
Babiker, Abdel, Chan, Man, Cotugno, Nicola, De Rossi, Anita, Epiical, Consortium, Ferns, Bridget, Fortuny, Claudia, Foster, Caroline, Freguja, Riccardo, Giaquinto, Carlo, Gibb, Diana, Judd, Ali, Klein, Nigel, Mellado, Mar\ueda Jos\ue9, Mu\uf1oz-Fern\ue1ndez, Mar\ueda Angeles, Nastouli, Eleni, Navarro, Mar\ueda Luisa, Noguera-Julian, Antoni, Palma, Paolo, Rojo, Pablo, Rossi, Paolo, Tagarro, Alfredo, Zangari, Paola   +22 more
core   +2 more sources

Predictors of SIV recrudescence following antiretroviral treatment interruption

eLife, 2019
There is currently a need for proxy measures of the HIV rebound competent reservoir (RCR) that can predict viral rebound after combined antiretroviral treatment (cART) interruption.
Mykola Pinkevych, Christine M Fennessey, Deborah Cromer, Carolyn Reid, Charles M Trubey, Jeffrey D Lifson, Brandon F Keele, Miles P Davenport   +7 more
doaj   +1 more source

Human immunodeficiency virus rebound after suppression to < 400 copies/mL during initial highly active antiretroviral therapy regimens, according to prior nucleoside experience and duration of suppression [PDF]

, 2002
This study evaluated 1433 human immunodeficiency virus (HIV)-infected patients starting highly active antiretroviral therapy (HAART), 409 (28%) of whom had prior nucleoside experience and achieved an HIV load of
Bickel, M, Doerr, HW, Johnson, MA, Klauke, S, Lampe, F, Loveday, C, Miller, V, Phillips, AN, Royal Free Ctr HIV Med Goethe Univ, Sabin, CA, Staszewski, S, Youle, MS   +11 more
core   +1 more source

Factors associated with post-treatment control of viral load in HIV-infected patients: a systematic review and meta-analysis

International Journal of Infectious Diseases, 2023
Objectives: This study aimed to investigate the factors associated with maintenance of viral suppression after antiretroviral therapy (ART) discontinuation.
Chi Zhou, Yaxin Wu, Yang Zhang, Yingying Wang, Hao Wu, Tong Zhang, Guanzhi Chen, Xiaojie Huang   +7 more
doaj   +1 more source

Evolution of experimental design and research techniques in HIV-1 reservoir studies : a systematic review

, 2020
Although HIV-1 has evolved from a deadly to a chronic disease over the past 20 years, an HIV-1 cure is still lacking due to the presence of persisting cellular viral reservoirs which are spread throughout the body in different anatomical compartments ...
De Scheerder, Marie-Angélique, Depelseneer, Bram, Vandekerckhove, Linos, Wim, Trypsteen   +3 more
core   +1 more source