Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1 [PDF]
, 2014 Massive research efforts are now underway to develop a cure for HIV infection, allowing patients to discontinue lifelong combination antiretroviral therapy (ART). New latency-reversing agents (LRAs) may be able to purge the persistent reservoir of latent
Fu, Feng +4 more
core +3 more sources
Illustration of a Measure to Combine Viral Suppression and Viral Rebound in Studies of HIV Therapy [PDF]
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2015 Viral load is an important tool for assessing antiretroviral treatment efficacy. However, the most common viral load endpoint, virologic failure, may be flawed. We illustrate an alternative endpoint that estimates the average time patients spent suppressed prior to rebound in the AIDS Clinical Trials Group A5095 trial.
Jessie K, Edwards +5 more
openaire +2 more sources
Impact of HLA Class I Alleles on Timing of HIV Rebound After Antiretroviral Treatment Interruption
Pathogens and Immunity, 2017 Identifying host determinants associated with HIV reservoir size and viral rebound timing after an analytic treatment interruption (ATI) is an important step in the search for an HIV functional cure.
You Park +11 more
doaj +1 more source
HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption [PDF]
Nature, 2016 Interruption of combination antiretroviral therapy in HIV-1-infected individuals leads to rapid viral rebound. Here we report the results of a phase IIa open label clinical trial evaluating 3BNC117,a broad and potent neutralizing antibody against the CD4 binding site of the HIV-1 Env protein, during analytical treatment interruption in 13 HIV-1 ...
Scheid, J. +32 more
openaire +4 more sources
Long lasting control of viral rebound with a new drug ABX464 targeting Rev – mediated viral RNA biogenesis [PDF]
Retrovirology, 2015 Current therapies have succeeded in controlling AIDS pandemic. However, there is a continuing need for new drugs, in particular those acting through new and as yet unexplored mechanisms of action to achieve HIV infection cure. We took advantage of the unique feature of proviral genome to require both activation and inhibition of splicing of viral ...
Campos, Noëlie +18 more
openaire +3 more sources
Wellcome Open Research, 2018 Background: There is a growing interest in the role of circadian regulated pathways in disease pathogenesis. Methods: In a cohort of hepatitis C virus (HCV) infected patients undergoing liver transplantation, we observed differences in early viral ...
Xiaodong Zhuang +4 more
doaj +1 more source
Virological and immunological outcome of treatment interruption in HIV-1-infected subjects vaccinated with MVA-B. [PDF]
PLoS ONE, 2017 The most relevant endpoint in therapeutic HIV vaccination is the assessment of time to viral rebound or duration of sustained control of low-level viremia upon cART treatment cessation.
Miriam Rosás-Umbert +16 more
doaj +1 more source
The Long Noncoding RNA HEAL Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter. [PDF]
, 2019 A major challenge in finding a cure for HIV-1/AIDS is the difficulty in identifying and eradicating persistent reservoirs of replication-competent provirus.
Chang, Kungyen +11 more
core +1 more source
Wellcome Open Research, 2018 Background: There is a growing interest in the role of circadian regulated pathways in disease pathogenesis. Methods: In a cohort of hepatitis C virus (HCV) infected patients undergoing liver transplantation, we observed differences in early viral ...
Xiaodong Zhuang +4 more
doaj +1 more source
An expert consensus for the management of chronic hepatitis B in Asian Americans. [PDF]
, 2018 BACKGROUND: Hepatitis B virus (HBV) infection is common with major clinical consequences. In Asian Americans, the HBsAg carrier rate ranges from 2% to 16% which approximates the rates from their countries of origin.
Abbas +173 more
core +2 more sources