Results 321 to 330 of about 2,155,361 (380)

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Advanced Science, EarlyView.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S. Yarla, Lu Wang, Jindan Yu, Jonathan C. Zhao, Ivet Bahar, Yong Wan   +14 more
wiley   +1 more source

Navigating a Fine Balance: Point-Mutant Cheater Viruses Disrupt the Viral Replication Cycle. [PDF]

Mol Biol Evol
Meir M, Kahn A, Farage C, Maoz Y, Harel N, Ben Zvi A, Segev S, Volkov M, Yahud R, Gophna U, Stern A.   +10 more
europepmc   +2 more sources

Absence of Viral Replication Is Associated With Improved Outcome in Anti-HCV-Positive Patients With Hepatocellular Carcinoma. [PDF]

Liver Int
Giannini EG, Pasta A, Plaz Torres MC, Pieri G, Cabibbo G, Sangiovanni A, Piscaglia F, Campani C, Missale G, Vidili G, Ghittoni G, Pelizzaro F, Foschi FG, Morisco F, Santi V, Svegliati-Baroni G, Azzaroli F, Saitta C, Brunetto MR, Sacco R, Ponziani FR, Boninsegna S, Nardone G, Martini A, Mega A, Sacerdoti D, Magalotti D, Vitale A, Bucci L, Trevisani F, Italian Liver Cancer (ITA.LI.CA) group.   +30 more
europepmc   +1 more source

Detection of infection-specific proteins in viral RNA replication complex from tobacco plants infected with cucumber mosaic virus.

, 1990
Naoto Nitta, Yoichi Takanami
openalex   +2 more sources

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

MARCH8 promotes the proteasomal degradation of foot-and-mouth disease virus VP1, VP2, and VP3 to negatively regulate viral replication. [PDF]

Vet Res
Yin M, Li X, Zhang M, Zhao Q, Wang H, Zhang H, Lu Z, Qian P.   +7 more
europepmc   +1 more source

ANTIBODIES TO HEPATITIS B VIRUS X-PROTEIN IN SERA OF CHRONIC INFECTED CHILDREN ARE ASSOCIATED WITH LOWER VIRAL REPLICATION

, 1991
Stéfan Wirth, J. Ohlmann, Klaus‐Michael Keller, E. Schaefer, Bernhard Zabel   +4 more
openalex   +1 more source

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Novel strand-specific qPCR assay elucidates differences in viral replication kinetics between different strains of avian reovirus. [PDF]

Microbiol Spectr
Harrell TL, Alvarez-Narvaez S, Read QD, Conrad SJ.   +3 more
europepmc   +1 more source

Optogenetic‐Controlled iPSC‐Based Vaccines for Prophylactic and Therapeutic Tumor Suppression in Mice

Advanced Science, EarlyView.
This study develops an a red/far‐red light‐controlled iPSC‐based vaccines (RIVA) based on the chimeric photosensory protein FnBphP and its interaction partner LDB3 for cancer immunotherapy. The RIVA preserves the multiple intrinsic tumor antigens of iPSCs and enables optogenetic control of the expression of the immune adjuvant type I interferon β under
Longliang Qiao, Lingxue Niu, Zhihao Wang, Di Dai, Shasha Tang, Xiaoding Ma, Zhenqiang Deng, Guiling Yu, Yang Zhou, Tao Yan, Xingwan Liu, Deqiang Kong, Linfeng Hu, Xiang Li, Junwei Zhao, Fengfeng Cai, Meiyan Wang, Haifeng Ye   +17 more
wiley   +1 more source