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Initiation of Viral DNA Replication
1988Publisher Summary This chapter focuses on the mechanisms involved in initiation of animal virus DNA replication. This step is of fundamental importance because it represents the central point of control of the replication process. Two of the best-characterized viruses, adenovirus and SV40, are discussed as examples of viruses that normally multiply ...
T J, Kelly, M S, Wold, J, Li
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MicroRNAs in Viral Replication and Pathogenesis
DNA and Cell Biology, 2007MicroRNAs (miRNAs) are an important class of small, noncoding, regulatory RNAs found to be involved in regulating a wide variety of important cellular processes by the sequence-specific inhibition of gene expression. Viruses have evolved a number of mechanisms to take advantage of the regulatory potential of this highly conserved, ubiquitous pathway ...
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Oxygen Biology and Viral Replication.
Virologie (Montrouge, France), 2014International ...
Morinet, Frédéric, Pillet, Sylvie
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Viral replication and the coactivators p300 and CBP
Trends in Microbiology, 2000Productive viral infection requires coordinate regulation of viral and cellular gene expression. Viruses of different classes have evolved different mechanisms to conform to, adapt to and exploit programs of cellular gene expression. Many viral gene products influence and respond to cellular signals that control differentiation and proliferation ...
M O, Hottiger, G J, Nabel
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1985
In the cytoplasm of an uninfected mammalian host cell, so far no enzymes have been detected that synthesize RNA on an RNA template. The incoming poliovirus contains a plus strand RNA but does not carry an RNA-replicase. Formation of replicase(s) is a prerequisite for the synthesis of viral progeny RNA.
Friedrich Koch, Gebhard Koch
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In the cytoplasm of an uninfected mammalian host cell, so far no enzymes have been detected that synthesize RNA on an RNA template. The incoming poliovirus contains a plus strand RNA but does not carry an RNA-replicase. Formation of replicase(s) is a prerequisite for the synthesis of viral progeny RNA.
Friedrich Koch, Gebhard Koch
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La Revue du praticien, 1997
The multiplication of viruses depends on the virus and the infected cell. Viruses seem to have evolved by several routes and no single pattern of replication has prevailed. The cells can be permissive with productive infection or not. The productive cycle of viruses infecting eukaryotic cells exhibit several common steps.
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The multiplication of viruses depends on the virus and the infected cell. Viruses seem to have evolved by several routes and no single pattern of replication has prevailed. The cells can be permissive with productive infection or not. The productive cycle of viruses infecting eukaryotic cells exhibit several common steps.
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Chronic hepatitis A with persistent viral replication
Journal of Medical Virology, 1996Hepatitis A virus (HAV) usually causes an acute self-limited illness. This report describes a patient with hepatitis A whose serum aminotransferase activities remained above normal and whose serum was persistently positive for immunoglobulin (Ig) M class anti-hepatitis A 31 months after the onset of hepatitis.
K, Inoue +5 more
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Viral replication and genetics
2016This chapter argues that viruses are at a major disadvantage in the task of reproducing themselves compared with higher forms of life. The latter all multiply by some form of fission, which ensures that the daughter cells start their existence with a full complement of genetic information, along with the enzymes necessary to replicate and catalyse the ...
John Oxford, Paul Kellam, Leslie Collier
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Inhibition of hepatitis viral replication by siRNA
Expert Opinion on Biological Therapy, 2004Small interfering RNA (siRNA)-mediated sequence-specific gene silencing is a powerful tool to inhibit endogenous and exogenous gene expression, and it holds great potential to prevent and eradicate viral infection, for which existing therapy is inadequate, such as HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV).
Jian, Wu, Kiran Mayi, Nandamuri
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1993
Abstract During the last decade considerable interest has focused upon the mechanisms by which the genomes of DNA animal viruses are replicated. These studies provide information relevant not only to our understanding of viral growth and potential strategies for intervention, but also to processes occurring during the replication of ...
Nigel D Stow, Ronald T Hay
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Abstract During the last decade considerable interest has focused upon the mechanisms by which the genomes of DNA animal viruses are replicated. These studies provide information relevant not only to our understanding of viral growth and potential strategies for intervention, but also to processes occurring during the replication of ...
Nigel D Stow, Ronald T Hay
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