Regulation of Viral Restriction by Post-Translational Modifications [PDF]
Viruses, 2021 Intrinsic immunity is orchestrated by a wide range of host cellular proteins called restriction factors. They have the capacity to interfere with viral replication, and most of them are tightly regulated by interferons (IFNs).
Célia Chamontin +4 more
doaj +5 more sources
Retroviral Restriction Factors and Their Viral Targets: Restriction Strategies and Evolutionary Adaptations [PDF]
Microorganisms, 2020 The evolutionary conflict between retroviruses and their vertebrate hosts over millions of years has led to the emergence of cellular innate immune proteins termed restriction factors as well as their viral antagonists.
Guney Boso, Christine A. Kozak
doaj +4 more sources
Sirtuins Are Evolutionarily Conserved Viral Restriction Factors [PDF]
mBio, 2014 The seven human sirtuins are a family of ubiquitously expressed and evolutionarily conserved NAD+-dependent deacylases/mono-ADP ribosyltransferases that regulate numerous cellular and organismal functions, including metabolism, cell cycle, and longevity.
Emre Koyuncu +6 more
doaj +6 more sources
Restriction Factors: From Intrinsic Viral Restriction to Shaping Cellular Immunity Against HIV-1 [PDF]
Frontiers in Immunology, 2018 Antiviral restriction factors are host cellular proteins that constitute a first line of defense blocking viral replication and propagation. In addition to interfering at critical steps of the viral replication cycle, some restriction factors also act as
Marta Colomer-Lluch +3 more
doaj +8 more sources
A phage weaponizes a satellite recombinase to subvert viral restriction. [PDF]
Nucleic Acids Res, 2022 Abstract Bacteria can acquire mobile genetic elements (MGEs) to combat infection by viruses (phages). Satellite viruses, including the PLEs (phage-inducible chromosomal island-like elements) in epidemic Vibrio cholerae, are MGEs that restrict phage replication to the benefit of their host bacterium.
Nguyen MHT +3 more
europepmc +7 more sources
DDX50 Is a Viral Restriction Factor That Enhances IRF3 Activation. [PDF]
Viruses, 2022 The transcription factors IRF3 and NF-κB are crucial in innate immune signalling in response to many viral and bacterial pathogens. However, mechanisms leading to their activation remain incompletely understood. Viral RNA can be detected by RLR receptors, such as RIG-I and MDA5, and the dsRNA receptor TLR3.
Pallett MA, Lu Y, Smith GL.
europepmc +7 more sources
DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication [PDF]
mBioThe SARS-CoV-2 pandemic and the emergence of novel variants underscore the need to understand host-virus interactions and identify host factors that restrict viral infection.
Fei Feng +27 more
doaj +4 more sources
Insights into the Structures and Multimeric Status of APOBEC Proteins Involved in Viral Restriction and Other Cellular Functions [PDF]
Viruses, 2021 Apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) proteins belong to a family of deaminase proteins that can catalyze the deamination of cytosine to uracil on single-stranded DNA or/and RNA.
Xiaojiang S. Chen
doaj +2 more sources
Methamphetamine facilitates HIV infection of primary human monocytes through inhibiting cellular viral restriction factors. [PDF]
Cell Biosci, 2021 Liu Y +7 more
europepmc +3 more sources
Genome replication dynamics of a bacteriophage and its satellite reveal strategies for parasitism and viral restriction. [PDF]
Nucleic Acids Res, 2020 Barth ZK +3 more
europepmc +3 more sources