Regulation of Viral Restriction by Post-Translational Modifications [PDF]
Viruses, 2021 Intrinsic immunity is orchestrated by a wide range of host cellular proteins called restriction factors. They have the capacity to interfere with viral replication, and most of them are tightly regulated by interferons (IFNs).
Célia Chamontin +4 more
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Restriction Factors: From Intrinsic Viral Restriction to Shaping Cellular Immunity Against HIV-1 [PDF]
Frontiers in Immunology, 2018 Antiviral restriction factors are host cellular proteins that constitute a first line of defense blocking viral replication and propagation. In addition to interfering at critical steps of the viral replication cycle, some restriction factors also act as
Marta Colomer-Lluch +3 more
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Sirtuins Are Evolutionarily Conserved Viral Restriction Factors [PDF]
mBio, 2014 The seven human sirtuins are a family of ubiquitously expressed and evolutionarily conserved NAD+-dependent deacylases/mono-ADP ribosyltransferases that regulate numerous cellular and organismal functions, including metabolism, cell cycle, and longevity.
Emre Koyuncu +6 more
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A phage weaponizes a satellite recombinase to subvert viral restriction. [PDF]
Nucleic Acids Res, 2022 Abstract Bacteria can acquire mobile genetic elements (MGEs) to combat infection by viruses (phages). Satellite viruses, including the PLEs (phage-inducible chromosomal island-like elements) in epidemic Vibrio cholerae, are MGEs that restrict phage replication to the benefit of their host bacterium.
Nguyen MHT +3 more
europepmc +7 more sources
Insights into the Structures and Multimeric Status of APOBEC Proteins Involved in Viral Restriction and Other Cellular Functions [PDF]
Viruses, 2021 Apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) proteins belong to a family of deaminase proteins that can catalyze the deamination of cytosine to uracil on single-stranded DNA or/and RNA.
Xiaojiang S. Chen
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Tombusvirus-yeast interactions identify conserved cell-intrinsic viral restriction factors [PDF]
Frontiers in Plant Science, 2014 To combat viral infections, plants possess innate and adaptive immune pathways, such as RNA silencing, R gene and recessive gene-mediated resistance mechanisms.
Zsuzsanna eSasvari +2 more
doaj +5 more sources
Genome replication dynamics of a bacteriophage and its satellite reveal strategies for parasitism and viral restriction. [PDF]
Nucleic Acids Res, 2020 Barth ZK +3 more
europepmc +3 more sources
Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity [PDF]
, 2010 TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5α but they have distinct lentiviral specificities, conferring HIV-1 ...
A Katzourakis +62 more
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Viruses, 2023 Rift Valley Fever virus (RVFV) and Toscana virus (TOSV) are two pathogenic arthropod-borne viruses responsible for zoonotic infections in both humans and animals; as such, they represent a growing threat to public and veterinary health.
Marie-Pierre Confort +8 more
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West Nile Virus Restriction in Mosquito and Human Cells: A Virus under Confinement
Vaccines, 2020 West Nile virus (WNV) is an emerging neurotropic flavivirus that naturally circulates between mosquitoes and birds. However, WNV has a broad host range and can be transmitted from mosquitoes to several mammalian species, including humans, through ...
Marie-France Martin, Sébastien Nisole
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