Results 91 to 100 of about 341,932 (331)

Endogenous TRIM5α Function Is Regulated by SUMOylation and Nuclear Sequestration for Efficient Innate Sensing in Dendritic Cells

Cell Reports, 2016
During retroviral infection, viral capsids are subject to restriction by the cellular factor TRIM5α. Here, we show that dendritic cells (DCs) derived from human and non-human primate species lack efficient TRIM5α-mediated retroviral restriction.
Débora M. Portilho, Juliette Fernandez, Mathieu Ringeard, Anthony K. Machado, Aude Boulay, Martha Mayer, Michaela Müller-Trutwin, Anne-Sophie Beignon, Frank Kirchhoff, Sébastien Nisole, Nathalie J. Arhel   +10 more
doaj   +1 more source

Increased Polymerase Activity of Zoonotic H7N9 Allows Partial Escape from MxA

Viruses, 2022
The interferon-induced myxovirus resistance protein A (MxA) is a potent restriction factor that prevents zoonotic infection from influenza A virus (IAV) subtype H7N9.
Philipp P. Petric, Jacqueline King, Laura Graf, Anne Pohlmann, Martin Beer, Martin Schwemmle   +5 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races

eLife, 2020
Host antiviral proteins engage in evolutionary arms races with viruses, in which both sides rapidly evolve at interaction interfaces to gain or evade immune defense.
Jeannette L Tenthorey, Candice Young, Afeez Sodeinde, Michael Emerman, Harmit S Malik   +4 more
doaj   +1 more source

Density waves theory of the capsid structure of small icosahedral viruses

, 2006
We apply Landau theory of crystallization to explain and to classify the capsid structures of small viruses with spherical topology and icosahedral symmetry.
D. L. D. Caspar, J. B. Bancroft, J. P. Elliot, L. D. Landau, L. D. Landau, S. B. Rochal, S. J. Flint, T. S. Baker, V. L. Lorman   +8 more
core   +3 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Cellular Restriction Factors of Feline Immunodeficiency Virus

Viruses, 2011
Lentiviruses are known for their narrow cell- and species-tropisms, which are determined by cellular proteins whose absence or presence either support viral replication (dependency factors, cofactors) or inhibit viral replication (restriction factors ...
Carsten Münk, Jörg Zielonka
doaj   +1 more source

Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha. [PDF]

PLoS Pathogens, 2007
TRIM5alpha is a restriction factor that limits infection of human cells by so-called N- but not B- or NB-tropic strains of murine leukemia virus (MLV). Here, we performed a mutation-based functional analysis of TRIM5alpha-mediated MLV restriction.
Pierre V Maillard, Séverine Reynard, Fatima Serhan, Priscilla Turelli, Didier Trono   +4 more
doaj   +1 more source

Baboon endogenous virus genome: Molecular cloning and structural characterization of nondefective viral genomes from DNA of a baboon cell strain [PDF]

, 1981
Several heterogeneities in the baboon endogenous virus (BaEV) genomes that are present in the DNA of normal baboon tissues and the baboon cell strain BEF-3 have been described previously.
Cohen, Maurice, Davidson, Norman, Gilden, Raymond V., McAllister, Robert M., Nicolson, Margery O., O'Connell, Catherine, Rein, Alan, Shure, Mavis, Stephens, Robert M.   +8 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source