Results 131 to 140 of about 344,723 (331)

Restriction of Viral Glycoprotein Maturation by Cellular Protease Inhibitors

Viruses
The human genome is estimated to encode more than 500 proteases performing a wide range of important physiological functions. They digest proteins in our food, determine the activity of hormones, induce cell death and regulate blood clotting, for example. During viral infection, however, some proteases can switch sides and activate viral glycoproteins,
Rishikesh Lotke, Moritz Petersen, Daniel Sauter   +2 more
openaire   +4 more sources

DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication

mBio
The SARS-CoV-2 pandemic and the emergence of novel variants underscore the need to understand host-virus interactions and identify host factors that restrict viral infection.
Fei Feng, Jiannan Chen, Rong Li, Yunkai Zhu, Yanlong Ma, Ziqiao Wang, Yuyan Wang, Zhichao Gao, Lulu Yang, Yin Yu, Yanfeng Liu, Yingjie Sun, Ying Liao, Xinxin Huang, Qisheng Zhang, Yongheng Huang, Lin Qiu, Jiayu Wu, Jingxian Zhao, Chao Liu, Qiang Ding, Youhua Xie, Zhenghong Yuan, Yue Hong, Ping Zhang, Jing Sun, Jincun Zhao, Rong Zhang   +27 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Expression in Escherichia coli of a cloned DNA sequence encoding the pre-S2 region of hepatitis B virus [PDF]

, 1985
A DNA sequence encoding the entire pre-S2 region (amino acids 120-174; serotype ayw) of human hepatitis B virus envelope protein has been inserted into the lacZ gene of the plasmid pSKS105 yielding a recombinant, pWS3.
Acs, George, Christman, Judith K., Kent, Stephen B. H., Neurath, A. Robert, Offensperger, Wolf, Price, Peter, Strick, Nathan, Wahl, Silke   +7 more
core   +1 more source

Methamphetamine facilitates HIV infection of primary human monocytes through inhibiting cellular viral restriction factors. [PDF]

Cell Biosci, 2021
Liu Y, Meng FZ, Wang X, Wang P, Liu JB, Hu WH, Young WB, Ho WZ.   +7 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

MicroRNA-376b-3p Promotes Porcine Reproductive and Respiratory Syndrome Virus Replication by Targeting Viral Restriction Factor TRIM22. [PDF]

J Virol, 2022
Chen J, Zhao S, Cui Z, Li W, Xu P, Liu H, Miao X, Chen Y, Han F, Zhang H, Xia P, Zhang Y.   +11 more
europepmc   +1 more source

Genome replication dynamics of a bacteriophage and its satellite reveal strategies for parasitism and viral restriction [PDF]

, 2019
Zachary K. Barth, Tania V. Silvas, Angus Angermeyer, Kimberley D. Seed   +3 more
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Disruption of Transmembrane Phosphatidylserine Asymmetry by HIV-1 Incorporated SERINC5 Is Not Responsible for Virus Restriction

Biomolecules
Host restriction factor SERINC5 (SER5) incorporates into the HIV-1 membrane and inhibits infectivity by a poorly understood mechanism. Recently, SER5 was found to exhibit scramblase-like activity leading to the externalization of phosphatidylserine (PS ...
Gokul Raghunath, Elizabeth H. Abbott, Mariana Marin, Hui Wu, Judith Mary Reyes Ballista, Melinda A. Brindley, Gregory B. Melikyan   +6 more
doaj   +1 more source