Results 11 to 20 of about 337,413 (230)

Regulation of viral replication by host restriction factors

Frontiers in Immunology
Viral infectious diseases, caused by numerous viruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A virus (IAV), enterovirus (EV), human immunodeficiency virus (HIV), hepatitis B virus (HBV), and human papillomavirus
Ying Lin, Ying Lin, Ying Lin, Yun Zhu, Yun Zhu, Ling Jing, Ling Jing, Ling Jing, Xiaobo Lei, Xiaobo Lei, Zhengde Xie, Zhengde Xie   +11 more
doaj   +4 more sources

How SAMHD1 changes our view of viral restriction. [PDF]

Trends Immunol, 2012
Recent studies have uncovered sterile alpha motif and HD domain 1 (SAMHD1) as the restriction factor that blocks HIV-1 replication in myeloid cells. In contrast to previously identified HIV-1 restriction factors, SAMHD1 does not meet a countermeasure developed by HIV-1.
Laguette N, Benkirane M.
europepmc   +7 more sources

IFITM proteins restrict viral membrane hemifusion.

PLoS Pathogens, 2013
The interferon-inducible transmembrane (IFITM) protein family represents a new class of cellular restriction factors that block early stages of viral replication; the underlying mechanism is currently not known.
Kun Li, Ruben M Markosyan, Yi-Min Zheng, Ottavia Golfetto, Brittani Bungart, Minghua Li, Shilei Ding, Yuxian He, Chen Liang, James C Lee, Enrico Gratton, Fredric S Cohen, Shan-Lu Liu   +12 more
doaj   +7 more sources

Tombusvirus-yeast interactions identify conserved cell-intrinsic viral restriction factors [PDF]

Frontiers in Plant Science, 2014
To combat viral infections, plants possess innate and adaptive immune pathways, such as RNA silencing, R gene and recessive gene-mediated resistance mechanisms.
Zsuzsanna eSasvari, Paulina eAlatriste Gonzalez, Peter eNagy   +2 more
doaj   +2 more sources

FAM111A induces nuclear dysfunction in disease and viral restriction. [PDF]

EMBO Rep, 2021
Mutations in the nuclear trypsin-like serine protease FAM111A cause Kenny-Caffey syndrome (KCS2) with hypoparathyroidism and skeletal dysplasia or perinatally lethal osteocraniostenosis (OCS). In addition, FAM111A was identified as a restriction factor for certain host range mutants of the SV40 polyomavirus and VACV orthopoxvirus.
Nie M, Oravcová M, Jami-Alahmadi Y, Wohlschlegel JA, Lazzerini-Denchi E, Boddy MN.   +5 more
europepmc   +7 more sources

Viral restriction goes nuclear [PDF]

Nature Reviews Microbiology, 2011
A specific nuclear PML isoform functions in the host response to infection by sequestering the viral polymerase of an RNA virus for which replication takes place in the cytoplasm.
Andrew Jermy
openalex   +4 more sources

Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors

Cell Reports
Summary: We developed viral sensor and restriction factor-cytometry by time of flight (VISOR-CyTOF), which profiles 19 viral sensors and restriction factors (VISORs) simultaneously in single cells, and applied it to 41 postmortem tissues from people with
Ashley F. George, Jason Neidleman, Xiaoyu Luo, Julie Frouard, Natalie Elphick, Kailin Yin, Kyrlia C. Young, Tongcui Ma, Alicer K. Andrew, Ifeanyi J. Ezeonwumelu, Jesper G. Pedersen, Antoine Chaillon, Magali Porrachia, Brendon Woodworth, Martin R. Jakobsen, Reuben Thomas, Davey M. Smith, Sara Gianella, Nadia R. Roan   +18 more
doaj   +2 more sources

Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity [PDF]

, 2010
TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5α but they have distinct lentiviral specificities, conferring HIV-1 ...
A Katzourakis, AJ Price, Amanda J. Price, C Apetrei, C Apetrei, C Besnier, CA Virgen, CH Liao, CJ Rold, CR Langelier, D Perez-Caballero, DM Sayah, EA Soares, EM Poeschla, F Gao, F Zhang, Flavia Marzetta, G Brennan, GJ Towers, Greg J. Towers, H Huthoff, J Foote, J Foote, J Li, Jane Rasaiyaah, Jeremy Luban, JW Bainbridge, L Van Valen, L Vergne, L Yin, L Ylinen, L Zheng, Laura M. J. Ylinen, LC James, LD Passerini, Leo C. James, LM Ylinen, M Stremlau, M Stremlau, M Stremlau, MW McNatt, MW Yap, MW Yap, Nicola J. Rose, R Zufferey, RE Randall, RJ Gifford, RK Gupta, RM Newman, S Paterson, SD Griffin, SJ Wilson, SL Sawyer, SL Sawyer, Stéphane Hué, T Hatziioannou, TR Gamble, VM Hirsch, WA McEwan, X Wu, Y Ikeda, Z Keckesova, ZJ da Silva   +62 more
core   +27 more sources

H-2 antigen restriction of viral infection (reply) [PDF]

Nature, 1975
Ertl, H., Koszinowski, Ulrich H.
core   +4 more sources

dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction. [PDF]

J Virol
Cheung P-HH, Yang H, Wu L.
europepmc   +2 more sources