Results 11 to 20 of about 341,932 (331)

Retroviral Restriction Factors and Their Viral Targets: Restriction Strategies and Evolutionary Adaptations

Microorganisms, 2020
The evolutionary conflict between retroviruses and their vertebrate hosts over millions of years has led to the emergence of cellular innate immune proteins termed restriction factors as well as their viral antagonists.
Guney Boso, Christine A. Kozak
doaj   +3 more sources

IFITM proteins restrict viral membrane hemifusion.

PLoS Pathogens, 2013
The interferon-inducible transmembrane (IFITM) protein family represents a new class of cellular restriction factors that block early stages of viral replication; the underlying mechanism is currently not known.
Kun Li, Ruben M Markosyan, Yi-Min Zheng, Ottavia Golfetto, Brittani Bungart, Minghua Li, Shilei Ding, Yuxian He, Chen Liang, James C Lee, Enrico Gratton, Fredric S Cohen, Shan-Lu Liu   +12 more
doaj   +6 more sources

Regulation of viral replication by host restriction factors

Frontiers in Immunology
Viral infectious diseases, caused by numerous viruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A virus (IAV), enterovirus (EV), human immunodeficiency virus (HIV), hepatitis B virus (HBV), and human papillomavirus
Ying Lin, Ying Lin, Ying Lin, Yun Zhu, Yun Zhu, Ling Jing, Ling Jing, Ling Jing, Xiaobo Lei, Xiaobo Lei, Zhengde Xie, Zhengde Xie   +11 more
doaj   +3 more sources

FAM111A induces nuclear dysfunction in disease and viral restriction. [PDF]

EMBO Rep, 2021
Mutations in the nuclear trypsin-like serine protease FAM111A cause Kenny-Caffey syndrome (KCS2) with hypoparathyroidism and skeletal dysplasia or perinatally lethal osteocraniostenosis (OCS). In addition, FAM111A was identified as a restriction factor for certain host range mutants of the SV40 polyomavirus and VACV orthopoxvirus.
Nie M, Oravcová M, Jami-Alahmadi Y, Wohlschlegel JA, Lazzerini-Denchi E, Boddy MN.   +5 more
europepmc   +6 more sources

dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction. [PDF]

J Virol
Cheung P-HH, Yang H, Wu L.
europepmc   +2 more sources

Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity [PDF]

, 2010
TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5α but they have distinct lentiviral specificities, conferring HIV-1 ...
A Katzourakis, AJ Price, Amanda J. Price, C Apetrei, C Apetrei, C Besnier, CA Virgen, CH Liao, CJ Rold, CR Langelier, D Perez-Caballero, DM Sayah, EA Soares, EM Poeschla, F Gao, F Zhang, Flavia Marzetta, G Brennan, GJ Towers, Greg J. Towers, H Huthoff, J Foote, J Foote, J Li, Jane Rasaiyaah, Jeremy Luban, JW Bainbridge, L Van Valen, L Vergne, L Yin, L Ylinen, L Zheng, Laura M. J. Ylinen, LC James, LD Passerini, Leo C. James, LM Ylinen, M Stremlau, M Stremlau, M Stremlau, MW McNatt, MW Yap, MW Yap, Nicola J. Rose, R Zufferey, RE Randall, RJ Gifford, RK Gupta, RM Newman, S Paterson, SD Griffin, SJ Wilson, SL Sawyer, SL Sawyer, Stéphane Hué, T Hatziioannou, TR Gamble, VM Hirsch, WA McEwan, X Wu, Y Ikeda, Z Keckesova, ZJ da Silva   +62 more
core   +27 more sources

Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization. [PDF]

Nucleic Acids Res, 2017
Adolph MB, Ara A, Feng Y, Wittkopp CJ, Emerman M, Fraser JS, Chelico L.   +6 more
europepmc   +3 more sources

Viral restriction goes nuclear [PDF]

Nature Reviews Microbiology, 2011
Andrew Jermy
openalex   +2 more sources

DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication

mBio
The SARS-CoV-2 pandemic and the emergence of novel variants underscore the need to understand host-virus interactions and identify host factors that restrict viral infection.
Fei Feng, Jiannan Chen, Rong Li, Yunkai Zhu, Yanlong Ma, Ziqiao Wang, Yuyan Wang, Zhichao Gao, Lulu Yang, Yin Yu, Yanfeng Liu, Yingjie Sun, Ying Liao, Xinxin Huang, Qisheng Zhang, Yongheng Huang, Lin Qiu, Jiayu Wu, Jingxian Zhao, Chao Liu, Qiang Ding, Youhua Xie, Zhenghong Yuan, Yue Hong, Ping Zhang, Jing Sun, Jincun Zhao, Rong Zhang   +27 more
doaj   +2 more sources

Restriction of Viral Replication by Mutation of the Influenza Virus Matrix Protein [PDF]

Journal of Virology, 2002
ABSTRACT The matrix protein (M1) of influenza virus plays an essential role in viral assembly and has a variety of functions, including association with influenza virus ribonucleoprotein (RNP). Our previous studies show that the association of M1 with viral RNA and nucleoprotein not only promotes formation of helical RNP but also is required ...
Teresa Liu, Zhiping Ye
openalex   +3 more sources