Results 21 to 30 of about 337,413 (230)
A Sorting Signal Suppresses IFITM1 Restriction of Viral Entry [PDF]
Journal of Biological Chemistry, 2014 The interferon-induced transmembrane proteins (IFITMs) broadly inhibit virus infections, particularly at the viral entry level. However, despite this shared ability to inhibit fusion, IFITMs differ in the potency and breadth of viruses restricted, an anomaly that is not fully understood. Here, we show that differences in the range of viruses restricted
Kun Li +11 more
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Host Cell Restriction Factors of Bunyaviruses and Viral Countermeasures [PDF]
Viruses, 2021 The Bunyavirales order comprises more than 500 viruses (generally defined as bunyaviruses) classified into 12 families. Some of these are highly pathogenic viruses infecting different hosts, including humans, mammals, reptiles, arthropods, birds, and/or plants.
Vincent Legros +4 more
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Restriction of Viral Replication by Mutation of the Influenza Virus Matrix Protein [PDF]
Journal of Virology, 2002 ABSTRACT The matrix protein (M1) of influenza virus plays an essential role in viral assembly and has a variety of functions, including association with influenza virus ribonucleoprotein (RNP). Our previous studies show that the association of M1 with viral RNA and nucleoprotein not only promotes formation of helical RNP but also is required ...
Teresa Liu, Zhiping Ye
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Viruses, 2023 Rift Valley Fever virus (RVFV) and Toscana virus (TOSV) are two pathogenic arthropod-borne viruses responsible for zoonotic infections in both humans and animals; as such, they represent a growing threat to public and veterinary health.
Marie-Pierre Confort +8 more
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Tethering Viral Restriction to Signal Transduction [PDF]
Cell Host & Microbe, 2014 Tetherin serves as an innate sensor of viral infection in addition to its role in inhibiting virus release from infected cells. In this issue, Galão et al. (2014) provide important insights into the mechanism of virus-induced signal transduction by tetherin.
Juan F. Arias, David T. Evans
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West Nile Virus Restriction in Mosquito and Human Cells: A Virus under Confinement
Vaccines, 2020 West Nile virus (WNV) is an emerging neurotropic flavivirus that naturally circulates between mosquitoes and birds. However, WNV has a broad host range and can be transmitted from mosquitoes to several mammalian species, including humans, through ...
Marie-France Martin, Sébastien Nisole
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SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5
Nature Communications, 2022 SERINC5, is a cellular multipass transmembrane protein involved in sphingolipid and phosphatydilserine biogenesis and a known retroviral restriction factor. Here, Timilsina et al.
Uddhav Timilsina +4 more
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Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses
Viruses, 2021 The transmission of viruses from animal hosts into humans have led to the emergence of several diseases. Usually these cross-species transmissions are blocked by host restriction factors, which are proteins that can block virus replication at a specific ...
Amit Gaba, Ben Flath, Linda Chelico
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mBio, 2023 Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphate triphosphohydrolase (dNTPase) and a potent restriction factor for immunodeficiency virus 1 (HIV-1), active in myeloid and resting CD4+ T cells.
Moritz Schüssler +7 more
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The Role of ZAP and TRIM25 RNA Binding in Restricting Viral Translation [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 The innate immune response controls the acute phase of virus infections; critical to this response is the induction of type I interferon (IFN) and resultant IFN-stimulated genes to establish an antiviral environment. One such gene, zinc finger antiviral protein (ZAP), is a potent antiviral factor that inhibits replication of diverse RNA and DNA viruses
Emily Yang +9 more
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