Results 21 to 30 of about 344,723 (331)
Host Cell Restriction Factors of Bunyaviruses and Viral Countermeasures [PDF]
Viruses, 2021 The Bunyavirales order comprises more than 500 viruses (generally defined as bunyaviruses) classified into 12 families. Some of these are highly pathogenic viruses infecting different hosts, including humans, mammals, reptiles, arthropods, birds, and/or plants.
Solène Lerolle +3 more
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Viral evasion of PKR restriction by reprogramming cellular stress granules
Proceedings of the National Academy of Sciences, 2022 Protein kinase R (PKR) is a critical host restriction factor against invading viral pathogens. However, this molecule is inactivated in the cells infected with porcine reproductive and respiratory syndrome virus (PRRSV), an economically devastating pathogen to the world swine industry.
Peng Gao +10 more
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H–2 antigen restriction of viral infection [PDF]
Nature, 1975 Kirsten Fischer Lindahl
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How SAMHD1 changes our view of viral restriction. [PDF]
Trends Immunol, 2012 Recent studies have uncovered sterile alpha motif and HD domain 1 (SAMHD1) as the restriction factor that blocks HIV-1 replication in myeloid cells. In contrast to previously identified HIV-1 restriction factors, SAMHD1 does not meet a countermeasure developed by HIV-1.
Laguette N, Benkirane M.
europepmc +5 more sources
Malnutrition and Energy Restriction Differentially Affect Viral Immunity [PDF]
The Journal of Nutrition, 2006 Protein-energy malnutrition is associated with a decrease in immunity and an increase in infectious disease. Both of these effects are exacerbated in aging. Conversely, energy restriction (ER) without malnutrition extends the lifespan in animals and retards the age-related decline in various parameters of immune function.
Barry W, Ritz, Elizabeth M, Gardner
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SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5
Nature Communications, 2022 SERINC5, is a cellular multipass transmembrane protein involved in sphingolipid and phosphatydilserine biogenesis and a known retroviral restriction factor. Here, Timilsina et al.
Uddhav Timilsina +4 more
doaj +1 more source
Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses
Viruses, 2021 The transmission of viruses from animal hosts into humans have led to the emergence of several diseases. Usually these cross-species transmissions are blocked by host restriction factors, which are proteins that can block virus replication at a specific ...
Amit Gaba, Ben Flath, Linda Chelico
doaj +1 more source
mBio, 2023 Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphate triphosphohydrolase (dNTPase) and a potent restriction factor for immunodeficiency virus 1 (HIV-1), active in myeloid and resting CD4+ T cells.
Moritz Schüssler +7 more
doaj +1 more source
Sequence organization of feline leukemis virus DNA in infected cells [PDF]
, 1980 A restriction site map has been deduced of unintegrated and integrated FeLV viral DNA found in human RD cells after experimental infection with the Gardner-Arnstein strain of FeLV.
Casey, James W. +3 more
core +1 more source
Neuronal itaconate restricts viral infection [PDF]
Nature Reviews Immunology, 2019 Zika virus infection of neurons triggers a cell death-independent pathway through the necroptotic kinases RIPK1 and RIPK3 that alters cellular metabolism to suppress viral replication.
openaire +2 more sources