Sequence organization of feline leukemis virus DNA in infected cells [PDF]
, 1980 A restriction site map has been deduced of unintegrated and integrated FeLV viral DNA found in human RD cells after experimental infection with the Gardner-Arnstein strain of FeLV.
Casey, James W. +3 more
core +1 more source
Evolutionary conflicts and adverse effects of antiviral factors
eLife, 2021 Human cells are equipped with a plethora of antiviral proteins protecting them against invading viral pathogens. In contrast to apoptotic or pyroptotic cell death, which serves as ultima ratio to combat viral infections, these cell-intrinsic restriction ...
Daniel Sauter, Frank Kirchhoff
doaj +1 more source
Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif [PDF]
Viruses, 2013 It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways. The APOBEC3 proteins are a mammalian-specific family of nucleic acid cytidine deaminases that block retroviral infection.
Valgerdur Andrésdóttir +1 more
openaire +4 more sources
Neuronal itaconate restricts viral infection [PDF]
Nature Reviews Immunology, 2019 Zika virus infection of neurons triggers a cell death-independent pathway through the necroptotic kinases RIPK1 and RIPK3 that alters cellular metabolism to suppress viral replication.
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Host-dependent restriction of mengovirus replication. II. Effect of host restriction on late viral RNA synthesis and viral maturation [PDF]
Journal of Virology, 1975 Restricted mengovirus replication in Mandin-Darby bovine kidney (MDBK) cells is characterized by a 400-fold reduction in infectious virus yield and a 40-fold increase in the production of noninfectious virus. Using conditions which insure that all MDBK cells are infected, virus-specific RNA and protein synthesis were measured in the restrictive host ...
M W Taylor, S O Prather
openaire +3 more sources
ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress
eLife, 2018 The mechanisms by which mammalian cells recognize and epigenetically restrict viral DNA are not well defined. We used herpes simplex virus with bioorthogonally labeled genomes to detect host factors recruited to viral DNA shortly after its nuclear entry ...
Joseph M Cabral +2 more
doaj +1 more source
Regulation of alphaherpesvirus infections by the ICP0 family of proteins [PDF]
, 2013 Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) is important for the regulation of lytic and latent viral infection. Like the related proteins expressed by other alphaherpesviruses, ICP0 has a zinc-stabilized RING finger domain that ...
Boutell, Chris, Everett, Roger
core +1 more source
IgG2a restriction of murine antibodies elicited by viral infections. [PDF]
The Journal of experimental medicine, 1987 The isotypic distribution of IgG antibodies was determined in the serum of mice after infection with a panel of RNA and DNA viruses representative of 11 different genera. The antiviral response induced by all these viruses showed a striking preponderance of the IgG2a subclass whatever the strain of mice tested or the time elapsed after infection ...
Coutelier, Jean-Paul +4 more
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Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA [PDF]
, 1986 Transformation of murine thymocytes by radiation leukemia virus is associated with reduced expression of the class I antigens encoded in the major histocompatibility complex (MHC) and increased methylation and altered restriction enzyme patterns of MHC ...
Boral, Anthony +11 more
core +1 more source
TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6
Nature, 2023 AbstractHuman tripartite motif protein 5α (TRIM5α) is a well-characterized restriction factor for some RNA viruses, including HIV1–5; however, reports are limited for DNA viruses6,7. Here we demonstrate that TRIM5α also restricts orthopoxviruses and, via its SPRY domain, binds to the orthopoxvirus capsid protein L3 to diminish virus replication and ...
Zhao, Yiqi +5 more
openaire +2 more sources