Malnutrition and Energy Restriction Differentially Affect Viral Immunity [PDF]
The Journal of Nutrition, 2006 Protein-energy malnutrition is associated with a decrease in immunity and an increase in infectious disease. Both of these effects are exacerbated in aging. Conversely, energy restriction (ER) without malnutrition extends the lifespan in animals and retards the age-related decline in various parameters of immune function.
Barry W, Ritz, Elizabeth M, Gardner
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How SAMHD1 changes our view of viral restriction. [PDF]
Trends Immunol, 2012 Recent studies have uncovered sterile alpha motif and HD domain 1 (SAMHD1) as the restriction factor that blocks HIV-1 replication in myeloid cells. In contrast to previously identified HIV-1 restriction factors, SAMHD1 does not meet a countermeasure developed by HIV-1.
Laguette N, Benkirane M.
europepmc +5 more sources
Evolutionary conflicts and adverse effects of antiviral factors
eLife, 2021 Human cells are equipped with a plethora of antiviral proteins protecting them against invading viral pathogens. In contrast to apoptotic or pyroptotic cell death, which serves as ultima ratio to combat viral infections, these cell-intrinsic restriction ...
Daniel Sauter, Frank Kirchhoff
doaj +1 more source
Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. [PDF]
, 2020 The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood.
Cavrois, Marielle +16 more
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Neuronal itaconate restricts viral infection [PDF]
Nature Reviews Immunology, 2019 Zika virus infection of neurons triggers a cell death-independent pathway through the necroptotic kinases RIPK1 and RIPK3 that alters cellular metabolism to suppress viral replication.
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ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress
eLife, 2018 The mechanisms by which mammalian cells recognize and epigenetically restrict viral DNA are not well defined. We used herpes simplex virus with bioorthogonally labeled genomes to detect host factors recruited to viral DNA shortly after its nuclear entry ...
Joseph M Cabral +2 more
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Restriction of HIV-1 Genotypes in Breast Milk Does Not Account for the Population Transmission Genetic Bottleneck That Occurs following Transmission [PDF]
, 2010 BACKGROUND. Breast milk transmission of HIV-1 remains a major route of pediatric infection. Defining the characteristics of viral variants to which breastfeeding infants are exposed is important for understanding the genetic bottleneck that occurs in the
Aldrovandi, Grace M. +15 more
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Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA [PDF]
, 1986 Transformation of murine thymocytes by radiation leukemia virus is associated with reduced expression of the class I antigens encoded in the major histocompatibility complex (MHC) and increased methylation and altered restriction enzyme patterns of MHC ...
Boral, Anthony +11 more
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A Sorting Signal Suppresses IFITM1 Restriction of Viral Entry [PDF]
Journal of Biological Chemistry, 2015 The interferon-induced transmembrane proteins (IFITMs) broadly inhibit virus infections, particularly at the viral entry level. However, despite this shared ability to inhibit fusion, IFITMs differ in the potency and breadth of viruses restricted, an anomaly that is not fully understood. Here, we show that differences in the range of viruses restricted
Kun, Li +11 more
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Regulation of alphaherpesvirus infections by the ICP0 family of proteins [PDF]
, 2013 Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) is important for the regulation of lytic and latent viral infection. Like the related proteins expressed by other alphaherpesviruses, ICP0 has a zinc-stabilized RING finger domain that ...
Boutell, Chris, Everett, Roger
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