Hepatitis B Virus Protein X Induces Degradation of Talin-1
Viruses, 2016 In the infected human hepatocyte, expression of the hepatitis B virus (HBV) accessory protein X (HBx) is essential to maintain viral replication in vivo.
Maarten A. A. van de Klundert +3 more
doaj +1 more source
Cofilin Activation in Peripheral CD4 T Cells of HIV-1 Infected Patients: A Pilot Study [PDF]
, 2008 Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form.
Barrett, Tracey +7 more
core +3 more sources
Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. [PDF]
, 2020 The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood.
Cavrois, Marielle +16 more
core +1 more source
Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells
eLife, 2016 We report that a major subpopulation of monocyte-derived macrophages (MDMs) contains high levels of dUTP, which is incorporated into HIV-1 DNA during reverse transcription (U/A pairs), resulting in pre-integration restriction and post-integration ...
Erik C Hansen +11 more
doaj +1 more source
Synthetic lethal mutations in the cyclin A interface of human cytomegalovirus. [PDF]
PLoS Pathogens, 2017 Generally, the antagonism between host restriction factors and viral countermeasures decides on cellular permissiveness or resistance to virus infection.
Henry Weisbach +5 more
doaj +1 more source
Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses. [PDF]
, 2015 BACKGROUND: Known antiretroviral restriction factors are encoded by genes that are under positive selection pressure, induced during HIV-1 infection, up-regulated by interferons, and/or interact with viral proteins.
Ciuffi, A. +16 more
core +2 more sources
Hijacking of the Ubiquitin/Proteasome Pathway by the HIV Auxiliary Proteins
Viruses, 2017 The ubiquitin-proteasome system (UPS) ensures regulation of the protein pool in the cell by ubiquitination of proteins followed by their degradation by the proteasome.
Tanja Seissler +2 more
doaj +1 more source
Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins. [PDF]
, 2019 The plasma membrane is a site of conflict between host defenses and many viruses. One aspect of this conflict is the host's attempt to eliminate infected cells using innate and adaptive cell-mediated immune mechanisms that recognize features of the ...
Guatelli, John +5 more
core +1 more source
Restricted Diffusion of the Splenium of the Corpus Callosum in Viral Meningitis [PDF]
The Neurohospitalist, 2013 Infarcts of the corpus callosum are rare. This may be due to the rich blood supply of the corpus callosum which includes the anterior and posterior cerebral arteries and the anterior communicating arteries.1 Sometimes, imaging findings suggestive of acute stroke can in fact be related to nonprimary stroke radiologic mimics such as an infectious process.
Muhammad U. Farooq +2 more
openaire +3 more sources
Malnutrition and Energy Restriction Differentially Affect Viral Immunity [PDF]
The Journal of Nutrition, 2006 Protein-energy malnutrition is associated with a decrease in immunity and an increase in infectious disease. Both of these effects are exacerbated in aging. Conversely, energy restriction (ER) without malnutrition extends the lifespan in animals and retards the age-related decline in various parameters of immune function.
Elizabeth M. Gardner, Barry W. Ritz
openaire +3 more sources