Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells
eLife, 2016 We report that a major subpopulation of monocyte-derived macrophages (MDMs) contains high levels of dUTP, which is incorporated into HIV-1 DNA during reverse transcription (U/A pairs), resulting in pre-integration restriction and post-integration ...
Erik C Hansen +11 more
doaj +1 more source
Synthetic lethal mutations in the cyclin A interface of human cytomegalovirus. [PDF]
PLoS Pathogens, 2017 Generally, the antagonism between host restriction factors and viral countermeasures decides on cellular permissiveness or resistance to virus infection.
Henry Weisbach +5 more
doaj +1 more source
Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins. [PDF]
, 2019 The plasma membrane is a site of conflict between host defenses and many viruses. One aspect of this conflict is the host's attempt to eliminate infected cells using innate and adaptive cell-mediated immune mechanisms that recognize features of the ...
Guatelli, John +5 more
core +1 more source
Hijacking of the Ubiquitin/Proteasome Pathway by the HIV Auxiliary Proteins
Viruses, 2017 The ubiquitin-proteasome system (UPS) ensures regulation of the protein pool in the cell by ubiquitination of proteins followed by their degradation by the proteasome.
Tanja Seissler +2 more
doaj +1 more source
Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses. [PDF]
, 2015 BACKGROUND: Known antiretroviral restriction factors are encoded by genes that are under positive selection pressure, induced during HIV-1 infection, up-regulated by interferons, and/or interact with viral proteins.
Ciuffi, A. +16 more
core +2 more sources
A Sorting Signal Suppresses IFITM1 Restriction of Viral Entry [PDF]
Journal of Biological Chemistry, 2015 The interferon-induced transmembrane proteins (IFITMs) broadly inhibit virus infections, particularly at the viral entry level. However, despite this shared ability to inhibit fusion, IFITMs differ in the potency and breadth of viruses restricted, an anomaly that is not fully understood. Here, we show that differences in the range of viruses restricted
Kun, Li +11 more
openaire +2 more sources
Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication
Cell Reports, 2019 Summary: To ensure a successful infection, herpesviruses have developed elegant strategies to counterbalance the host anti-viral responses. Sterile alpha motif and HD domain 1 (SAMHD1) was recently identified as an intrinsic restriction factor for a ...
Kun Zhang, Dong-Wen Lv, Renfeng Li
doaj +1 more source
Rapid identification and differentiation of the vaccine strain Rac H from EHV 1 field isolates using a non-radioactive DNA probe [PDF]
, 1992 A method for rapid differentiation between the EHV 1 live vaccine strain Rac H and field isolates is described. Total DNA was isolated from virus-infected small scale cell cultures.
Eichhorn, Werner +3 more
core +1 more source
eLife, 2020 Systemic oxygen restriction (SOR) is prevalent in numerous clinical conditions, including chronic obstructive pulmonary disease (COPD), and is associated with increased susceptibility to viral infections.
Amijai Saragovi +6 more
doaj +1 more source
mBio, 2019 Several host cell nuclear factors are known to restrict herpes simplex virus 1 (HSV-1) replication, but their mechanisms of action remain to be defined.
Philipp E. Merkl, David M. Knipe
doaj +1 more source