The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1) [PDF]
, 2016 Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting
Boutell, Chris +7 more
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Mechanisms of restriction of viral neuroinvasion at the blood–brain barrier
Current Opinion in Immunology, 2016 The blood-brain barrier (BBB) consists of highly specialized cells including brain microvascular endothelial cells, astrocytes, microglia, pericytes, and neurons, which act in concert to restrict the entry of pathogens, immune cells, and soluble molecules into the central nervous system (CNS).
Jonathan J. Miner, Michael S. Diamond
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Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging [PDF]
Frontiers in Immunology, 2017 Viruses assemble large macromolecular repeat structures that become part of the infectious particles or virions. Ribonucleocapsids (RNCs) of negative strand RNA viruses are a prime example where repetition of nucleoprotein (NP) along the genome creates a core polymeric helical scaffold that accommodates other nucleocapsid proteins including viral ...
Tamarand Lee Darling +3 more
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CMPK2 restricts Zika virus replication by inhibiting viral translation
PLOS Pathogens, 2023 Flaviviruses continue to emerge as global health threats. There are currently no Food and Drug Administration (FDA) approved antiviral treatments for flaviviral infections. Therefore, there is a pressing need to identify host and viral factors that can be targeted for effective therapeutic intervention.
Joanna B. Pawlak +9 more
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Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication
Cell Reports, 2019 Summary: To ensure a successful infection, herpesviruses have developed elegant strategies to counterbalance the host anti-viral responses. Sterile alpha motif and HD domain 1 (SAMHD1) was recently identified as an intrinsic restriction factor for a ...
Kun Zhang, Dong-Wen Lv, Renfeng Li
doaj +1 more source
eLife, 2020 Systemic oxygen restriction (SOR) is prevalent in numerous clinical conditions, including chronic obstructive pulmonary disease (COPD), and is associated with increased susceptibility to viral infections.
Amijai Saragovi +6 more
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Human and murine IFIT1 proteins do not restrict infection of negative-sense RNA viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae families [PDF]
, 2015 UNLABELLED: Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses.
Amarasinghe, Gaya +12 more
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SERINC as a Restriction Factor to Inhibit Viral Infectivity and the Interaction with HIV [PDF]
Journal of Immunology Research, 2017 The serine incorporator 5 (SERINC5) is a recently discovered restriction factor that inhibits viral infectivity by preventing fusion. Retroviruses have developed strategies to counteract the action of SERINC5, such as the expression of proteins like negative regulatory factor (Nef), S2, and glycosylated Gag (glycoGag).
Eduardo Vázquez-Valls +4 more
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mBio, 2019 Several host cell nuclear factors are known to restrict herpes simplex virus 1 (HSV-1) replication, but their mechanisms of action remain to be defined.
Philipp E. Merkl, David M. Knipe
doaj +1 more source