Human and murine IFIT1 proteins do not restrict infection of negative-sense RNA viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae families [PDF]
, 2015 UNLABELLED: Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses.
Amarasinghe, Gaya +12 more
core +3 more sources
Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication
Cell Reports, 2019 Summary: To ensure a successful infection, herpesviruses have developed elegant strategies to counterbalance the host anti-viral responses. Sterile alpha motif and HD domain 1 (SAMHD1) was recently identified as an intrinsic restriction factor for a ...
Kun Zhang, Dong-Wen Lv, Renfeng Li
doaj +1 more source
Versatile HIV Rev-dependent reporter cell system for stringent and sensitive quantification of viral reservoirs, neutralizing antibodies, and restriction factors [PDF]
Spear M +14 more
europepmc +2 more sources
eLife, 2020 Systemic oxygen restriction (SOR) is prevalent in numerous clinical conditions, including chronic obstructive pulmonary disease (COPD), and is associated with increased susceptibility to viral infections.
Amijai Saragovi +6 more
doaj +1 more source
mBio, 2019 Several host cell nuclear factors are known to restrict herpes simplex virus 1 (HSV-1) replication, but their mechanisms of action remain to be defined.
Philipp E. Merkl, David M. Knipe
doaj +1 more source
Mechanisms of restriction of viral neuroinvasion at the blood–brain barrier
Current Opinion in Immunology, 2016 The blood-brain barrier (BBB) consists of highly specialized cells including brain microvascular endothelial cells, astrocytes, microglia, pericytes, and neurons, which act in concert to restrict the entry of pathogens, immune cells, and soluble molecules into the central nervous system (CNS).
Miner, Jonathan J, Diamond, Michael S
openaire +2 more sources
IFITM3: How genetics influence influenza infection demographically
Biomedical Journal, 2019 The role of host genetics in influenza infection is unclear despite decades of interest. Confounding factors such as age, sex, ethnicity and environmental factors have made it difficult to assess the role of genetics without influence.
Dannielle Wellington +3 more
doaj +1 more source
The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1) [PDF]
, 2016 Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting
Boutell, Chris +7 more
core +1 more source
Synthesis of Viral Ribonucleic Acid During Restricted Adenovirus Infection [PDF]
Journal of Virology, 1972 The mechanism by which simian virus 40 converts the abortive adenovirus type 7 infection of monkey cells into an efficient lytic infection has been investigated. Analysis of ribonucleic acid (RNA) synthesis during unenhanced and enhanced infection of monkey cells has shown that adenovirus RNA synthesized in the abortive infection contains both “early ...
R I, Fox, S G, Baum
openaire +2 more sources
Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain [PDF]
Journal of Virology, 2016 ABSTRACT We have discovered that native, neuronal expression of alpha-synuclein (Asyn) inhibits viral infection, injury, and disease in the central nervous system (CNS). Enveloped RNA viruses, such as West Nile virus (WNV), invade the CNS and cause encephalitis, yet little is known about the innate neuron-specific inhibitors of ...
Erica L, Beatman +6 more
openaire +2 more sources