The interferon-stimulated gene IFITM3 restricts infection and pathogenesis of arthritogenic and encephalitic alphaviruses [PDF]
, 2016 Host cells respond to viral infections by producing type I interferon (IFN), which induces the expression of hundreds of interferon-stimulated genes (ISGs).
Diamond, Michael S +4 more
core +2 more sources
Host and viral determinants for MxB restriction of HIV-1 infection [PDF]
Retrovirology, 2014 Interferon-induced cellular proteins play important roles in the host response against viral infection. The Mx family of dynamin-like GTPases, which include MxA and MxB, target a wide variety of viruses. Despite considerable evidence demonstrating the breadth of antiviral activity of MxA, human MxB was only recently discovered to specifically inhibit ...
Alan Engelman +6 more
openaire +4 more sources
Restriction of HIV-1 Genotypes in Breast Milk Does Not Account for the Population Transmission Genetic Bottleneck That Occurs following Transmission [PDF]
, 2010 BACKGROUND. Breast milk transmission of HIV-1 remains a major route of pediatric infection. Defining the characteristics of viral variants to which breastfeeding infants are exposed is important for understanding the genetic bottleneck that occurs in the
Aldrovandi, Grace M. +15 more
core +8 more sources
The Intricate Interplay between APOBEC3 Proteins and DNA Tumour Viruses
PathogensAPOBEC3 proteins are cytidine deaminases that play a crucial role in the innate immune response against viruses, including DNA viruses. Their main mechanism for restricting viral replication is the deamination of cytosine to uracil in viral DNA during ...
Nika Lovšin +2 more
doaj +1 more source
IFITM3: How genetics influence influenza infection demographically
Biomedical Journal, 2019 The role of host genetics in influenza infection is unclear despite decades of interest. Confounding factors such as age, sex, ethnicity and environmental factors have made it difficult to assess the role of genetics without influence.
Dannielle Wellington +3 more
doaj +1 more source
The interferon-stimulated gene IFITM3 restricts West Nile virus infection and pathogenesis [PDF]
, 2016 The interferon-induced transmembrane protein (IFITM) family of proteins inhibit infection of several different enveloped viruses in cell culture by virtue of their ability to restrict entry and fusion from late endosomes.
Bradbury LE +6 more
core +2 more sources
Correction to: Differential neurovirulence of Usutu viruslineages in mice and neuronal cells
Journal of Neuroinflammation, 2021 An amendment to this paper has been published and can be accessed via the original article.
Marion Clé +19 more
doaj +1 more source
Baboon endogenous virus genome. I. Restriction enzyme map of the unintegrated DNA genome of a primate retrovirus [PDF]
, 1980 A detailed restriction map was deduced for the genome of an endogenous retrovirus of a higher primate, that of baboon. The cleavage sites for 12 restriction enzymes were mapped. The unintegrated linear viral DNA intermediate that is produced by infection
Cohen, Maurice +6 more
core
TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation [PDF]
Cell Reports, 2019 AbstractTripartite motif-containing protein 5α (TRIM5α) functions as a cellular antiviral restriction factor with exquisite specificity towards the capsid lattices of retroviruses. The relative avidity of TRIM5α binding to retrovirus capsids directly impacts primate species susceptibility to infection, but the antiviral role of TRIM5α is thought ...
Chiramel, Abhilash I. +19 more
openaire +5 more sources
Nature CommunicationsUsutu virus (USUV) and West Nile virus (WNV) are two closely related emerging mosquito-borne flaviviruses. Their natural hosts are wild birds, but they can also cause severe neurological disorders in humans.
Jim Zoladek +14 more
doaj +1 more source