Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles. [PDF]
, 2018 Combination antiretroviral therapy fails in complete suppression of HIV-1 due to drug resistance and persistent latency. Novel therapeutic intervention requires knowledge of intracellular pathways responsible for viral replication, specifically those ...
Arizala, Jerlisa Ann C +5 more
core +1 more source
Synthesis of Viral Ribonucleic Acid During Restricted Adenovirus Infection [PDF]
Journal of Virology, 1972 The mechanism by which simian virus 40 converts the abortive adenovirus type 7 infection of monkey cells into an efficient lytic infection has been investigated. Analysis of ribonucleic acid (RNA) synthesis during unenhanced and enhanced infection of monkey cells has shown that adenovirus RNA synthesized in the abortive infection contains both “early ...
Robert I. Fox, Stephen G. Baum
openaire +3 more sources
HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G. [PDF]
PLoS Pathogens, 2018 HIV-1 replication normally requires Vif-mediated neutralization of APOBEC3 antiviral enzymes. Viruses lacking Vif succumb to deamination-dependent and -independent restriction processes.
Terumasa Ikeda +5 more
doaj +1 more source
Molecular bases and role of viruses in the human microbiome. [PDF]
, 2014 Viruses are dependent biological entities that interact with the genetic material of most cells on the planet, including the trillions within the human microbiome.
Abeles, Shira R, Pride, David T
core +1 more source
Viruses, 2021 Human immunodeficiency virus-1 (HIV-1) persists as a global health concern, with an incidence rate of approximately 2 million, and estimated global prevalence of over 35 million.
Alexandra P. M. Cloherty +3 more
doaj +1 more source
Construction of a "mutagenesis cartridge" for poliovirus genome-linked viral protein: Isolation and characterization of viable and nonviable mutants [PDF]
, 1988 By following a strategy of genetic analysis of poliovirus, we have constructed a synthetic "mutagenesis cartridge" spanning the genome-linked viral protein coding region and flanking cleavage sites in an infectious cDNA clone of the type 1 (Mahoney ...
Dunn, John J. +5 more
core
Viral evasion of PKR restriction by reprogramming cellular stress granules
Proceedings of the National Academy of Sciences, 2022 Protein kinase R (PKR) is a critical host restriction factor against invading viral pathogens. However, this molecule is inactivated in the cells infected with porcine reproductive and respiratory syndrome virus (PRRSV), an economically devastating pathogen to the world swine industry.
Peng Gao +10 more
openaire +2 more sources
HIV-1 Virus-like Particle Budding Assay
Bio-Protocol, 2013 Viral replication culminates with the egress of the mature virion from the host cell. This step of the viral life cycle has recently garnered increased attention with the discovery of the cellular restriction factor, Tetherin, which tethers budded ...
Nathan Vande Burgt +2 more
doaj +1 more source
A Genetic Locus Regulates the Expression of Tissue-Specific mRNAs from Multiple Transcription Units [PDF]
, 1982 129 GIX- mice, unlike animals of the congeneic partner strain GIX+, do not express significant amounts of the retroviral antigens gp70 and p30. Evidence is presented indicating that the GIX phenotype is specified by a distinct regulatory gene acting on ...
Lerner, Richard A. +2 more
core +2 more sources
Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism
iScienceSummary: Most mammalian cells prevent viral infection and proliferation by expressing various restriction factors and sensors that activate the immune system.
Binbin Yi +9 more
doaj +1 more source