Results 71 to 80 of about 344,723 (331)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

HIV-1 Virus-like Particle Budding Assay

Bio-Protocol, 2013
Viral replication culminates with the egress of the mature virion from the host cell. This step of the viral life cycle has recently garnered increased attention with the discovery of the cellular restriction factor, Tetherin, which tethers budded ...
Nathan Vande Burgt, Luis Cocka , Paul Bates   +2 more
doaj   +1 more source

A Genetic Locus Regulates the Expression of Tissue-Specific mRNAs from Multiple Transcription Units [PDF]

, 1982
129 GIX- mice, unlike animals of the congeneic partner strain GIX+, do not express significant amounts of the retroviral antigens gp70 and p30. Evidence is presented indicating that the GIX phenotype is specified by a distinct regulatory gene acting on ...
Lerner, Richard A., Levy, David E., Wilson, Michael C.   +2 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection [PDF]

Journal of Clinical Investigation, 2017
Type I IFNs promote cellular responses to viruses, and IFN receptor (IFNAR) signaling regulates the responses of endothelial cells of the blood-brain barrier (BBB) during neurotropic viral infection. However, the role of astrocytes in innate immune responses of the BBB during viral infection of the CNS remains to be fully elucidated.
Daniels, Brain P, Jujjavarapu, Harsha, Durrant, Douglas M, Williams, Jessica L, Green, Richard R, White, James P, Lazear, Helen M, Gale, Michael, Jr., Diamond, Michael S, Klein, Robyn S   +9 more
openaire   +3 more sources

Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism

iScience
Summary: Most mammalian cells prevent viral infection and proliferation by expressing various restriction factors and sensors that activate the immune system.
Binbin Yi, Yuri L. Tanaka, Daphne Cornish, Hidetaka Kosako, Erika P. Butlertanaka, Prabuddha Sengupta, Jennifer Lippincott-Schwartz, Judd F. Hultquist, Akatsuki Saito, Shige H. Yoshimura   +9 more
doaj   +1 more source

Endogenous TRIM5α Function Is Regulated by SUMOylation and Nuclear Sequestration for Efficient Innate Sensing in Dendritic Cells

Cell Reports, 2016
During retroviral infection, viral capsids are subject to restriction by the cellular factor TRIM5α. Here, we show that dendritic cells (DCs) derived from human and non-human primate species lack efficient TRIM5α-mediated retroviral restriction.
Débora M. Portilho, Juliette Fernandez, Mathieu Ringeard, Anthony K. Machado, Aude Boulay, Martha Mayer, Michaela Müller-Trutwin, Anne-Sophie Beignon, Frank Kirchhoff, Sébastien Nisole, Nathalie J. Arhel   +10 more
doaj   +1 more source

BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction. [PDF]

PLoS Pathogens, 2009
Host cell factors can either positively or negatively regulate the assembly and egress of HIV-1 particles from infected cells. Recent reports have identified a previously uncharacterized transmembrane protein, tetherin/CD317/BST-2, as a crucial host ...
Kei Miyakawa, Akihide Ryo, Tsutomu Murakami, Kenji Ohba, Shoji Yamaoka, Mitsunori Fukuda, John Guatelli, Naoki Yamamoto   +7 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Studies on the restriction of murine leukemia viruses by mouse APOBEC3.

PLoS ONE, 2012
APOBEC3 proteins function to restrict the replication of retroviruses. One mechanism of this restriction is deamination of cytidines to uridines in (-) strand DNA, resulting in hypermutation of guanosines to adenosines in viral (+) strands.
Silvia Sanchez-Martinez, Amanda L Aloia, Demetria Harvin, Jane Mirro, Robert J Gorelick, Patric Jern, John M Coffin, Alan Rein   +7 more
doaj   +1 more source