Results 81 to 90 of about 337,413 (230)
Cell Reports, 2016 During retroviral infection, viral capsids are subject to restriction by the cellular factor TRIM5α. Here, we show that dendritic cells (DCs) derived from human and non-human primate species lack efficient TRIM5α-mediated retroviral restriction.
Débora M. Portilho +10 more
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BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction. [PDF]
PLoS Pathogens, 2009 Host cell factors can either positively or negatively regulate the assembly and egress of HIV-1 particles from infected cells. Recent reports have identified a previously uncharacterized transmembrane protein, tetherin/CD317/BST-2, as a crucial host ...
Kei Miyakawa +7 more
doaj +1 more source
Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. [PDF]
, 2014 BST2/tetherin, an antiviral restriction factor, inhibits the release of enveloped viruses from the cell surface. Human immunodeficiency virus-1 (HIV-1) antagonizes BST2 through viral protein u (Vpu), which downregulates BST2 from the cell surface.
Guatelli, John +7 more
core +1 more source
Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain [PDF]
Journal of Virology, 2016 ABSTRACT We have discovered that native, neuronal expression of alpha-synuclein (Asyn) inhibits viral infection, injury, and disease in the central nervous system (CNS). Enveloped RNA viruses, such as West Nile virus (WNV), invade the CNS and cause encephalitis, yet little is known about the innate neuron-specific inhibitors of ...
J. David Beckham +6 more
openaire +3 more sources
HIV suppression by host restriction factors and viral immune evasion [PDF]
Current Opinion in Structural Biology, 2015 Antiviral restriction factors are an integral part of the host innate immune system that protects cells from viral pathogens, such as human immunodeficiency virus (HIV). Studies of the interactions between restriction factors and HIV have greatly advanced our understanding of both the viral life cycle and basic cell biology, as well as provided new ...
Xiaofei Jia, Qi Zhao, Yong Xiong
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Studies on the restriction of murine leukemia viruses by mouse APOBEC3.
PLoS ONE, 2012 APOBEC3 proteins function to restrict the replication of retroviruses. One mechanism of this restriction is deamination of cytidines to uridines in (-) strand DNA, resulting in hypermutation of guanosines to adenosines in viral (+) strands.
Silvia Sanchez-Martinez +7 more
doaj +1 more source
Increased Polymerase Activity of Zoonotic H7N9 Allows Partial Escape from MxA
Viruses, 2022 The interferon-induced myxovirus resistance protein A (MxA) is a potent restriction factor that prevents zoonotic infection from influenza A virus (IAV) subtype H7N9.
Philipp P. Petric +5 more
doaj +1 more source
eLife, 2020 Host antiviral proteins engage in evolutionary arms races with viruses, in which both sides rapidly evolve at interaction interfaces to gain or evade immune defense.
Jeannette L Tenthorey +4 more
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Cellular Restriction Factors of Feline Immunodeficiency Virus
Viruses, 2011 Lentiviruses are known for their narrow cell- and species-tropisms, which are determined by cellular proteins whose absence or presence either support viral replication (dependency factors, cofactors) or inhibit viral replication (restriction factors ...
Carsten Münk, Jörg Zielonka
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Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha. [PDF]
PLoS Pathogens, 2007 TRIM5alpha is a restriction factor that limits infection of human cells by so-called N- but not B- or NB-tropic strains of murine leukemia virus (MLV). Here, we performed a mutation-based functional analysis of TRIM5alpha-mediated MLV restriction.
Pierre V Maillard +4 more
doaj +1 more source