Results 121 to 130 of about 24,194,770 (306)

Exploring nucleo-cytoplasmic large DNA viruses in Tara Oceans microbial metagenomes [PDF]

, 2013
Nucleo-cytoplasmic large DNA viruses (NCLDVs) constitute a group of eukaryotic viruses that can have crucial ecological roles in the sea by accelerating the turnover of their unicellular hosts or by causing diseases in animals. To better characterize the
Moreau, Hervé, Lima-Medez, Gipsi, Department of Applied Biological Sciences (DBIT), Vrije Universiteit Brussel, Brussels, Belgium, Bork, Peer, Subirana, Lucie, Wincker, Patrick, Poulain, Julie, Sarmento, Hugo, Desdevises, Yves, Villar, Emilie, Kandels-Lewis, Stefanie, Acinas, Silvia G., Faust, Karoline, Ogata, Hiroyuki, Grimsley, Nigel, Pesant, Stéphane, Jaillon, Olivier, Claverie, Jean-Michel, Hingamp, Pascal, Not, Fabrice, Karsenti, Eric, Clerissi, Camille, Ferrera, Isabel, de Vargas, Colomban, Sunagawa, Shinichi, Raes, Jeroen   +25 more
core   +1 more source

Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses

Scientific Reports, 2018
Avian influenza virus is a zoonotic agent that significantly impacts public health and the poultry industry. Monitoring viral evolution and spread is crucial for surveillance and tracing programmes, which are currently based on serological or DNA ...
Alireza Heidari, Irene Righetto, Francesco Filippini   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Identification and profiling of novel metagenome assembled uncultivated virus genomes from human gut

Virology Journal
Metagenomics has revealed an unprecedented viral diversity in human gut although, most of the sequence data remains uncharacterized. In this study, we mined a collection of 1090 metagenome assembled “high quality” viral genomes (> 90% completeness, as ...
Kanchan Bhardwaj, Niharika, Anjali Garg, Aakriti Jain, Manish Kumar, Manish Datt, Vijay Singh, Sudhanshu Vrati   +7 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo. [PDF]

, 2012
Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent alteration upon lytic murine cytomegalovirus (MCMV) infection is the rapid degradation of the ...
Lisnić, V. (V) J. (J), Marcinowski, Lisa, Tanguy, M. (M), Ruzsics, Zsolt, Tanguy Mélanie, Ralf Zimmer, Jonjic, S. (S), Erhard, F. (F), Krmpotic Astrid, Marina Babic (184917), Corinna Benkartek, Bernd Rädle (138968), Zsolt Ruzsics, Babic, Marina, Ruzsics, Z. (Zsolt), Jonjic Stipan, Trgovcich, Joanne, Erhard, Florian, Chane-woon-ming, B. (Béatrice), Tanguy, Mélanie, Chane-Woon-Ming Béatrice, Koszinowski, U. (Ulrich H), Marcinowski Lisa, Marina Babic, Ulrich H Koszinowski, Koszinowski Ulrich H., Joanne Trgovcich (184921), Astrid Krmpotic (184892), Stipan Jonjic (139671), Stipan Jonjic, Babic Marina, Vanda J. Lisnić (184897), Krmpotic, A. (A), Sébastien Pfeffer, Benkartek Corinna, Zsolt Ruzsics (75383), Béatrice Chane-Woon-Ming (184904), Zimmer Ralf, Lisa Marcinowski (138962), Marcinowski, L. (L), Marcinowski, L. (Lisa), Krmpotic, Astrid, Dölken, Lars, Béatrice Chane-Woon-Ming, Joanne Trgovcich, Rädle Bernd, Trgovcich, J. (Joanne), Rädle, B. (Bernd), Lars Dölken, Astrid Krmpotic, Florian Erhard (184910), Lars Dölken (138985), Babic, M. (M), Jonjic, S. (Stipan), Ulrich H. Koszinowski (152143), Lisnić, Vanda J., Lisnić, V. (Vanda J), Trgovcich Joanne, Benkartek, Corinna, Zimmer, Ralf, Erhard Florian, Dölken Lars, Ruzsics, Z. (Z), Ralf Zimmer (21157), Rädle, B. (B), Dölken, L. (L), Vanda J Lisnić, Tuddenham, L. (Lee), Trgovcich, J. (J), Lisnić Vanda J., Lee Tuddenham (141455), Pfeffer, S. (Sebastien), Rädle, Bernd, Corinna Benkartek (184913), Lisa Marcinowski, Zimmer, R. (Ralf), Tuddenham Lee, Benkartek, C. (C), Lee Tuddenham, Erhard, F. (Florian), Pfeffer Sébastien, Babic, M. (Marina), Tuddenham, Lee, Mélanie Tanguy (4691986), Mélanie Tanguy, Florian Erhard, Koszinowski, U. (U) H. (H), Ruzsics Zsolt, Krmpotic, A. (Astrid), Koszinowski, Ulrich H., Tanguy, M. (Mélanie), Dölken, L. (Lars), Zimmer, R. (R), Chane-Woon-Ming, Béatrice, Bernd Rädle, Sébastien Pfeffer (8264), Pfeffer, Sébastien, Benkartek, C. (Corinna), Jonjic, Stipan   +98 more
core   +1 more source

The Impact of HIV-1 Genetic Diversity on CRISPR-Cas9 Antiviral Activity and Viral Escape

Viruses, 2019
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system is widely explored for sequence-specific attack on HIV-1 proviral DNA.
Gilles Darcis, Caroline S. Binda, Bep Klaver, Elena Herrera-Carrillo, Ben Berkhout, Atze T. Das   +5 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Characterizing Host microRNA: Virus Interactions of Orthoavulavirus javaense

Viruses
Post-transcriptional gene regulation mediated by microRNAs (miRNAs) relies on sequence complementarity between the miRNA seed site and the target gene transcript(s). This complementarity can completely inhibit or reduce translation into protein.
Megan C. Mears, Abhijeet Bakre
doaj   +1 more source