Results 31 to 40 of about 540,107 (353)

Structural Motifs and Spatial Structures of Helicase (NS3) and RNA-dependent RNA-polymerase (NS5) of a Flavi-like Kindia tick virus (unclassified Flaviviridae)

open access: yesВопросы вирусологии, 2023
Introduction. Kindia tick virus (KITV) is a novel segmented unclassified flavi-like virus of the Flaviviridae family. This virus is associated with ixodes ticks and is potentially pathogenic to humans.
A. A. Gladysheva   +3 more
doaj   +1 more source

Keratinocyte differentiation-dependent human papillomavirus gene regulation [PDF]

open access: yes, 2017
Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte.
Graham, Sheila V.
core   +1 more source

A viral-human interactome based on structural motif-domain interactions captures the human infectome. [PDF]

open access: yesPLoS ONE, 2013
Protein interactions between a pathogen and its host are fundamental in the establishment of the pathogen and underline the infection mechanism. In the present work, we developed a single predictive model for building a host-viral interactome based on ...
Aldo Segura-Cabrera   +3 more
doaj   +1 more source

Identification and characterization of coiled-coil motifs across Autographa californica multiple nucleopolyhedrovirus genome

open access: yesHeliyon, 2022
Coiled coils (CCs) are protein structural motifs universally found in proteins and mediate a plethora of biological interactions, and thus their reliable annotation is crucial for studies of protein structure and function. Autographa californica multiple
Jianxiang Qiu   +3 more
doaj   +1 more source

Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry [PDF]

open access: yes, 2012
Protein phosphorylation is a common post-translational modification in eukaryotic cells and has a wide range of functional effects. Here, we used mass spectrometry to search for phosphorylated residues in all the proteins of influenza A and B viruses ...
Denham, Eleanor M.   +8 more
core   +3 more sources

MultiBac: from protein complex structures to synthetic viral nanosystems [PDF]

open access: yesBMC Biology, 2017
The MultiBac baculovirus/insect cell expression vector system was conceived as a user-friendly, modular tool-kit for producing multiprotein complexes for structural biology applications. MultiBac has allowed the structure and function of many molecular machines to be elucidated, including previously inaccessible high-value drug targets.
Pelosse, Martin   +5 more
openaire   +5 more sources

The Interplay of Viral and Host Factors in Chikungunya Virus Infection: Targets for Antiviral Strategies

open access: yesViruses, 2018
Chikungunya virus (CHIKV) has re-emerged as one of the many medically important arboviruses that have spread rampantly across the world in the past decade.
Kai Zhi Wong, Justin Jang Hann Chu
doaj   +1 more source

Non-structural proteins of arthropod-borne bunyaviruses: roles and functions [PDF]

open access: yes, 2013
Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus ...
Alain Kohl   +17 more
core   +3 more sources

Sindbis viral structural protein cytotoxicity on human neuroblastoma cells [PDF]

open access: yesPediatric Surgery International, 2020
Abstract Purpose Oncolytic viral therapy for neuroblastoma (NB) cells with Sindbis virus (SINV) is a promising strategy for treating high-risk NB. Here, we evaluated the possibility of using SINV structural proteins as therapeutic agents for NB since UV-inactivated SINV could induce cytopathogenic effects.
Eriko Y. Saito   +9 more
openaire   +2 more sources

A saposin-lipoprotein nanoparticle system for membrane proteins. [PDF]

open access: yes, 2016
A limiting factor in membrane protein research is the ability to solubilize and stabilize such proteins. Detergents are used most often for solubilizing membrane proteins, but they are associated with protein instability and poor compatibility with ...
Armache, Jean-Paul   +13 more
core   +2 more sources

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