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Picornaviruses: A View from 3A
Viruses, 2021 Picornaviruses are comprised of a positive-sense RNA genome surrounded by a protein shell (or capsid). They are ubiquitous in vertebrates and cause a wide range of important human and animal diseases. The genome encodes a single large polyprotein that is
Terry Jackson, Graham J. Belsham
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Targeting Viral Surface Proteins through Structure-Based Design [PDF]
Viruses, 2021 The emergence of novel viral infections of zoonotic origin and mutations of existing human pathogenic viruses represent a serious concern for public health. It warrants the establishment of better interventions and protective therapies to combat the virus and prevent its spread.
Yogesh B Narkhede +2 more
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International Journal of Infectious Diseases, 2023 Intro: Influenza A virus, a respiratory pathogen known to manipulate various cellular metabolic processes including glycolysis. Our earlier studies demonstrated the interaction of influenza A viral structural proteins; nucleoprotein and matrix protein ...
P. Goyal, M.S. Rajala
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The structure of viral coat protein and its role in disease
Trends in Microbiology, 1993 Because the structure of the tobacco mosaic virus capsid protein is known, mutations that alter the phenotype of the virus-plant interaction can be correlated with structural changes in this protein. These mutations affect the disease symptoms caused by the virus and recognition of the virus by a plant resistance gene product.
S. Chapman, A.G.C. Lindbeck and W.O. Dawson are in the University of Florida, Citrus Research and Education Center Experiment Station Road, Lake Alfred, FL 33850, USA ( host institution ) +3 more
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Structure and Role of O-Linked Glycans in Viral Envelope Proteins
Annual Review of Virology, 2023 N- and O-glycans are both important constituents of viral envelope glycoproteins. O-linked glycosylation can be initiated by any of 20 different human polypeptide O-acetylgalactosaminyl transferases, resulting in an important functional O-glycan heterogeneity.
Olofsson, Sigvard +3 more
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Biomolecules, 2018 Membrane fusion proteins are responsible for viral entry into host cells—a crucial first step in viral infection. These proteins undergo large conformational changes from pre-fusion to fusion-initiation structures, and, despite differences in viral
Anna Lappala +8 more
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Nonstructural protein NS80 is crucial in recruiting viral components to form aquareoviral factories. [PDF]
PLoS ONE, 2013 BACKGROUND: Replication and assembly of vertebrate reoviruses occur in specific intracellular compartments known as viral factories. Recently, NS88 and NS80, the nonstructural proteins from aquareoviruses, have been proposed to share common traits with ...
Fei Ke, Li-Bo He, Qi-Ya Zhang
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Illuminating structural proteins in viral “dark matter” with metaproteomics [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Marine viruses are abundant and have substantial ecosystem impacts, yet their study is hampered by the dominance of unannotated viral genes. Here, we use metaproteomics and metagenomics to examine virion-associated proteins in marine viral communities, providing tentative functions for 677,000 viral genomic sequences and the ...
Brum, Jennifer R +8 more
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Deciphering the Role of Bovine Viral Diarrhea Virus Non-Structural NS4B Protein in Viral Pathogenesis [PDF]
Veterinary Sciences, 2020 Bovine viral diarrhea virus (BVDV) is a (+) ssRNA virus that belongs to the family Flaviviridae. BVDV is a significant animal pathogen causing substantial economic losses to the cattle industry worldwide through respiratory and gastrointestinal infections and abortion or birth of persistently infected calves.
Bashir, Shahbaz +3 more
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Characterisation of a rare, reassortant human G10P[14] rotavirus strain detected in Honduras
Memorias do Instituto Oswaldo CruzBACKGROUND Although first detected in animals, the rare rotavirus strain G10P[14] has been sporadically detected in humans in Slovenia, Thailand, United Kingdom and Australia among other countries. Earlier studies suggest that the strains found in humans
Osbourne Quaye +8 more
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