Results 31 to 40 of about 363,177 (305)

Bluetongue virus non-structural protein 1 is a positive regulator of viral protein synthesis. [PDF]

, 2012
BACKGROUND: Bluetongue virus (BTV) is a double-stranded RNA (dsRNA) virus of the Reoviridae family, which encodes its genes in ten linear dsRNA segments.
Roy Polly, Boyce, Mark, Roy, Polly, Celma, Cristina CP, Cristina C P Celma, Boyce Mark, Mark Boyce, Polly Roy, Celma Cristina C P   +8 more
core   +1 more source

Illuminating structural proteins in viral “dark matter” with metaproteomics [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Marine viruses are abundant and have substantial ecosystem impacts, yet their study is hampered by the dominance of unannotated viral genes. Here, we use metaproteomics and metagenomics to examine virion-associated proteins in marine viral communities, providing tentative functions for 677,000 viral genomic sequences and the ...
Brum, Jennifer R, Ignacio-Espinoza, J Cesar, Kim, Eun-Hae, Trubl, Gareth, Jones, Robert M, Roux, Simon, VerBerkmoes, Nathan C, Rich, Virginia I, Sullivan, Matthew B   +8 more
openaire   +4 more sources

Picornaviruses: A View from 3A

Viruses, 2021
Picornaviruses are comprised of a positive-sense RNA genome surrounded by a protein shell (or capsid). They are ubiquitous in vertebrates and cause a wide range of important human and animal diseases. The genome encodes a single large polyprotein that is
Terry Jackson, Graham J. Belsham
doaj   +1 more source

The structure of viral coat protein and its role in disease

Trends in Microbiology, 1993
Because the structure of the tobacco mosaic virus capsid protein is known, mutations that alter the phenotype of the virus-plant interaction can be correlated with structural changes in this protein. These mutations affect the disease symptoms caused by the virus and recognition of the virus by a plant resistance gene product.
S. Chapman, A.G.C. Lindbeck and W.O. Dawson are in the University of Florida, Citrus Research and Education Center Experiment Station Road, Lake Alfred, FL 33850, USA ( host institution ), Chapman, Sean, Lindbeck, Alwyn G.C., Dawson, William O.   +3 more
openaire   +3 more sources

Structural basis for the coevolution of a viral RNA–protein complex [PDF]

Nature Structural & Molecular Biology, 2007
The cocrystal structure of the PP7 bacteriophage coat protein in complex with its translational operator identifies a distinct mode of sequence-specific RNA recognition when compared to the well-characterized MS2 coat protein-RNA complex. The structure reveals the molecular basis of the PP7 coat protein's ability to selectively bind its cognate RNA ...
Jeffrey A, Chao, Yury, Patskovsky, Steven C, Almo, Robert H, Singer   +3 more
openaire   +2 more sources

Structure and Role of O-Linked Glycans in Viral Envelope Proteins

Annual Review of Virology, 2023
N- and O-glycans are both important constituents of viral envelope glycoproteins. O-linked glycosylation can be initiated by any of 20 different human polypeptide O-acetylgalactosaminyl transferases, resulting in an important functional O-glycan heterogeneity.
Olofsson, Sigvard, Bally, Marta, Trybala, Edward, Bergström, Tomas   +3 more
openaire   +3 more sources

Cowpea mosaic virus 32- and 60-kilodalton replication proteins target and change the morphology of endoplasmic reticulum membranes [PDF]

, 2002
Cowpea mosaic virus (CPMV) replicates in close association with small membranous vesicles that are formed by rearrangements of intracellular membranes. To determine which of the viral proteins are responsible for the rearrangements of membranes and the ...
Lent, J., van, Jan E. Carette, Carette, J.E., MacFarlance, S.A., Jan van Lent, Wellink, J.E., van Lent, J., Stuart A. MacFarlane, Ab van Kammen, Joan Wellink, van Kammen, A., Kammen, A., van   +11 more
core   +1 more source

Structural Transition and Antibody Binding of EBOV GP and ZIKV E Proteins from Pre-Fusion to Fusion-Initiation State

Biomolecules, 2018
Membrane fusion proteins are responsible for viral entry into host cells—a crucial first step in viral infection. These proteins undergo large conformational changes from pre-fusion to fusion-initiation structures, and, despite differences in viral
Anna Lappala, Wataru Nishima, Jacob Miner, Paul Fenimore, Will Fischer, Peter Hraber, Ming Zhang, Benjamin McMahon, Chang-Shung Tung   +8 more
doaj   +1 more source

ROLE OF HOST CELL GLYCOLYTIC PROTEINS; ALPHA ENOLASE AND PYRUVATE KINASE IN INFLUENZA A VIRUS INFECTED CELLS

International Journal of Infectious Diseases, 2023
Intro: Influenza A virus, a respiratory pathogen known to manipulate various cellular metabolic processes including glycolysis. Our earlier studies demonstrated the interaction of influenza A viral structural proteins; nucleoprotein and matrix protein ...
P. Goyal, M.S. Rajala
doaj   +1 more source

Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction [PDF]

, 2014
This work was supported by the Wellcome Trust (grant AL087751/B)RIG-I and mda-5 are activated by viral RNA and stimulate type I interferon production. Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD ...
Childs, Kay, Randall, Richard, Goodbourn, Stephen   +2 more
core   +1 more source