Results 11 to 20 of about 361,433 (303)

Artificial neural networks trained to detect viral and phage structural proteins.

open access: yesPLoS Computational Biology, 2012
Phages play critical roles in the survival and pathogenicity of their hosts, via lysogenic conversion factors, and in nutrient redistribution, via cell lysis.
Victor Seguritan   +7 more
doaj   +3 more sources

Structural Virology: The Key Determinants in Development of Antiviral Therapeutics

open access: yesViruses
Structural virology has emerged as the foundation for the development of effective antiviral therapeutics. It is pivotal in providing crucial insights into the three-dimensional frame of viruses and viral proteins at atomic-level or near-atomic-level ...
Tanuj Handa   +6 more
doaj   +2 more sources

Molecular basis of COVID-19 pathogenesis and in silico studies of potential pharmacological treatment

open access: yesRevista de la Facultad de Medicina Humana, 2021
COVID-19 is a disease caused by SARS-CoV-2, a virus that represents a serious threat to global health. The objective of the article is to deepen into the structure of the structural and non-structural proteins of SARS-CoV-2 and their role during the ...
Eduardo Rubén Lam Cabanillas   +7 more
doaj   +1 more source

VPDB: Viral Protein Structural Database [PDF]

open access: yesBioinformation, 2011
Viral Protein Database is an interactive database for three dimensional viral proteins. Our aim is to provide a comprehensive resource to the community of structural virology, with an emphasis on the description of derived data from structural biology.
Om Prakash, Sharma   +3 more
openaire   +2 more sources

Protein–Protein Interfaces in Viral Capsids Are Structurally Unique [PDF]

open access: yesJournal of Molecular Biology, 2015
Viral capsids exhibit elaborate and symmetrical architectures of defined sizes and remarkable mechanical properties not seen with cellular macromolecular complexes. Given the uniqueness of the higher-order organization of viral capsid proteins in the virosphere, we explored the question of whether the patterns of protein-protein interactions within ...
Shanshan, Cheng, Charles L, Brooks
openaire   +2 more sources

Structures and Dynamics of Dengue Virus Nonstructural Membrane Proteins

open access: yesMembranes, 2022
Dengue virus is an important human pathogen threating people, especially in tropical and sub-tropical regions. The viral genome has one open reading frame and encodes one polyprotein which can be processed into structural and nonstructural (NS) proteins.
Qingxin Li, Congbao Kang
doaj   +1 more source

Dengue Virus Non-Structural Protein 5 as a Versatile, Multi-Functional Effector in Host–Pathogen Interactions

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
Dengue is emerging as one of the most prevalent mosquito-borne viral diseases of humans. The 11kb RNA genome of the dengue virus encodes three structural proteins (envelope, pre-membrane, capsid) and seven non-structural proteins (NS1, NS2A, NS2B, NS3 ...
Priya Bhatnagar   +6 more
doaj   +1 more source

Visualization and analysis of hepatitis C virus structural proteins at lipid droplets by super-resolution microscopy. [PDF]

open access: yesPLoS ONE, 2014
Cytosolic lipid droplets are central organelles in the Hepatitis C Virus (HCV) life cycle. The viral capsid protein core localizes to lipid droplets and initiates the production of viral particles at lipid droplet-associated ER membranes. Core is thought
Dennis Eggert   +3 more
doaj   +1 more source

Genes of SARS-CoV-2 and emerging variants [PDF]

open access: yesMicrobiology Australia, 2021
The pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is distinctly different from outbreaks caused by other coronaviruses: SARS-CoV andMiddle East respiratory syndrome coronavirus (MERS-CoV).
Ian Macreadie, Sudip Dhakal
doaj  

An Overview of Spike Surface Glycoprotein in Severe Acute Respiratory Syndrome–Coronavirus

open access: yesFrontiers in Molecular Biosciences, 2021
The novel coronavirus originated in December 2019 in Hubei, China. This contagious disease named as COVID-19 resulted in a massive expansion within 6 months by spreading to more than 213 countries.
Muthu Kumaradoss Kathiravan   +5 more
doaj   +1 more source

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