Results 11 to 20 of about 540,107 (353)

Viral structural proteins as targets for antivirals. [PDF]

Curr Opin Virol, 2020
Viral structural proteins are emerging as effective targets for new antivirals. In a viral lifecycle, the capsid must assemble, disassemble, and respond to host proteins, all at the right time and place. These reactions work within a narrow range of conditions, making them susceptible to small molecule interference.
Schlicksup CJ, Zlotnick A.
europepmc   +4 more sources

The biological functions of PRRSV nonstructural protein NSP2 in viral infection and replication and its role in host regulatory mechanisms [PDF]

Frontiers in Veterinary Science
Porcine reproductive and respiratory syndrome virus (PRRSV) is a single-stranded, positive-sense arterivirus that causes reproductive and respiratory disorders in sows.
Zhenzhen Zheng, Mengsi Zhang, Yue Zhang, Hewei Zhang, Jingqiang Ren   +4 more
doaj   +2 more sources

Viral capsid proteins are segregated in structural fold space.

PLoS Computational Biology, 2013
Viral capsid proteins assemble into large, symmetrical architectures that are not found in complexes formed by their cellular counterparts. Given the prevalence of the signature jelly-roll topology in viral capsid proteins, we are interested in whether ...
Shanshan Cheng, Charles L Brooks
doaj   +4 more sources

Small-molecule PS10 inhibits PRRSV replication by targeting HSP90 and multiple viral non-structural proteins

Journal of Virology
Livestock production is vital to global food security but faces major threats from pathogens such as porcine reproductive and respiratory syndrome virus (PRRSV), which causes substantial economic losses.
Yongjie Chen, Jingxing Wang, Haotong Lu, Zishen Chen, Baoying Huang, Chunhe Guo   +5 more
doaj   +2 more sources

Bergamottin Inhibits PRRSV Replication by Blocking Viral Non-Structural Proteins Expression and Viral RNA Synthesis

Viruses, 2023
The porcine reproductive and respiratory syndrome virus (PRRSV) causes economic losses in the swine industry worldwide. However, current vaccines cannot provide effective protection against PRRSV, and PRRSV-specific treatments for infected herds are ...
Zhenbang Zhu, Yuqian Xu, Lulu Chen, Meng Zhang, Xiangdong Li   +4 more
doaj   +3 more sources

Single self-cleaving mRNA vaccine expressing multiple viral structural proteins elicits robust immune responses and protects nursing piglets against PDCoV infection. [PDF]

J Virol
Yu R, Bai Y, Zhang L, Zhou P, Zhang Z, Yang J, Lu Y, Wang D, Peng Y, Li D, He J, Wang Y, Zhang Q, Yuan L, Guo H, Pan L, Liu X.   +16 more
europepmc   +2 more sources

Proviral NUP153 binding to viral proteins and RNA regulates structural–nonstructural protein ratios in orthoflavivirus infection [PDF]

Nature Communications
Orthoflaviviruses are RNA viruses that cause serious diseases in humans, with currently no antivirals available. Targeting host factors is emerging as an attractive antiviral approach.
Marie B. A. Peters, Richard Lindqvist, Eszter Kassa, Wai-Lok Yau, Pallabi Sengupta, Isabell Niedermoser, Gisa Gerold, Nasim Sabouri, Ylva Ivarsson, Richard Lundmark, Anna K. Överby   +10 more
doaj   +2 more sources

Roles of African swine fever virus structural proteins in viral infection [PDF]

Journal of Veterinary Research, 2017
African swine fever virus (ASFV) is a large, double-stranded DNA virus and the sole member of the Asfarviridae family. ASFV infects domestic pigs, wild boars, warthogs, and bush pigs, as well as soft ticks (Ornithodoros erraticus), which likely act as a ...
Jia Ning, Ou Yunwen, Pejsak Zygmunt, Zhang Yongguang, Zhang Jie   +4 more
doaj   +3 more sources

Targeting Viral Surface Proteins through Structure-Based Design [PDF]

Viruses, 2021
The emergence of novel viral infections of zoonotic origin and mutations of existing human pathogenic viruses represent a serious concern for public health. It warrants the establishment of better interventions and protective therapies to combat the virus and prevent its spread.
Yogesh B Narkhede, Karen J Gonzalez, Eva-Maria Strauch   +2 more
openaire   +3 more sources

Molecular basis of COVID-19 pathogenesis and in silico studies of potential pharmacological treatment

Revista de la Facultad de Medicina Humana, 2021
COVID-19 is a disease caused by SARS-CoV-2, a virus that represents a serious threat to global health. The objective of the article is to deepen into the structure of the structural and non-structural proteins of SARS-CoV-2 and their role during the ...
Eduardo Rubén Lam Cabanillas, Anthony Omar León Risco, Kevyn Bryce León Risco, Gaby Lisbeth Llamo Hoyos, Rosa María López Zavaleta, Estefanía del Rocío Luzuriaga Tirado, Alex Michael Mendoza Blas, Juan Jorge Huamán Saavedra   +7 more
doaj   +1 more source