Results 1 to 10 of about 363,177 (305)

Viral capsid proteins are segregated in structural fold space. [PDF]

PLoS Computational Biology, 2013
Viral capsid proteins assemble into large, symmetrical architectures that are not found in complexes formed by their cellular counterparts. Given the prevalence of the signature jelly-roll topology in viral capsid proteins, we are interested in whether ...
Shanshan Cheng, Charles L Brooks
doaj   +7 more sources

Viral structural proteins as targets for antivirals. [PDF]

Curr Opin Virol, 2020
Viral structural proteins are emerging as effective targets for new antivirals. In a viral lifecycle, the capsid must assemble, disassemble, and respond to host proteins, all at the right time and place. These reactions work within a narrow range of conditions, making them susceptible to small molecule interference.
Schlicksup CJ, Zlotnick A.
europepmc   +4 more sources

Aquareovirus NS80 Initiates Efficient Viral Replication by Retaining Core Proteins within Replication-Associated Viral Inclusion Bodies. [PDF]

PLoS ONE, 2015
Viral inclusion bodies (VIBs) are specific intracellular compartments for reoviruses replication and assembly. Aquareovirus nonstructural protein NS80 has been identified to be the major constituent for forming globular VIBs in our previous study.
Liming Yan, Jie Zhang, Hong Guo, Shicui Yan, Qingxiu Chen, Fuxian Zhang, Qin Fang   +6 more
doaj   +3 more sources

Non-structural proteins of bovine viral diarrhea virus

Virus Genes, 2022
Bovine viral diarrhea virus (BVDV) belongs to the family Flaviviridae genus pestivirus. The viral genome is a single-stranded, positive-sense RNA that encodes four structural proteins (i.e., C, Erns, E1, and E2) and eight non-structural proteins (NSPs) (i.e., Npro, p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B). Cattle infected with BVDV exhibit a number of
Si Chen, Linzhu Ren, Shanshan Chi
exaly   +3 more sources

The evolutionary dynamics between viral mimics and host proteins [PDF]

Molecular Systems Biology
Viral proteins interact with host proteins to hijack cellular pathways important for viral replication. Viral mimics are proteins whose structural similarity to host-mimicked proteins allows them to interact with mutual host targets. This mimicry poses a
Rotem Fuchs, Ofir Schor, Bar Naim, Dafna Tussia-Cohen, Alessandra Mozzi, Diego Forni, Sivan Friedman, Zohar Haggai, Manuela Sironi, Tzachi Hagai   +9 more
doaj   +2 more sources

Artificial neural networks trained to detect viral and phage structural proteins.

PLoS Computational Biology, 2012
Phages play critical roles in the survival and pathogenicity of their hosts, via lysogenic conversion factors, and in nutrient redistribution, via cell lysis.
Victor Seguritan, Nelson Alves, Michael Arnoult, Amy Raymond, Don Lorimer, Alex B Burgin, Peter Salamon, Anca M Segall   +7 more
doaj   +3 more sources

Molecular basis of COVID-19 pathogenesis and in silico studies of potential pharmacological treatment

Revista de la Facultad de Medicina Humana, 2021
COVID-19 is a disease caused by SARS-CoV-2, a virus that represents a serious threat to global health. The objective of the article is to deepen into the structure of the structural and non-structural proteins of SARS-CoV-2 and their role during the ...
Eduardo Rubén Lam Cabanillas, Anthony Omar León Risco, Kevyn Bryce León Risco, Gaby Lisbeth Llamo Hoyos, Rosa María López Zavaleta, Estefanía del Rocío Luzuriaga Tirado, Alex Michael Mendoza Blas, Juan Jorge Huamán Saavedra   +7 more
doaj   +1 more source

VPDB: Viral Protein Structural Database [PDF]

Bioinformation, 2011
Viral Protein Database is an interactive database for three dimensional viral proteins. Our aim is to provide a comprehensive resource to the community of structural virology, with an emphasis on the description of derived data from structural biology.
Om Prakash, Sharma, Ankush, Jadhav, Afzal, Hussain, Muthuvel Suresh, Kumar   +3 more
openaire   +2 more sources

Protein–Protein Interfaces in Viral Capsids Are Structurally Unique [PDF]

Journal of Molecular Biology, 2015
Viral capsids exhibit elaborate and symmetrical architectures of defined sizes and remarkable mechanical properties not seen with cellular macromolecular complexes. Given the uniqueness of the higher-order organization of viral capsid proteins in the virosphere, we explored the question of whether the patterns of protein-protein interactions within ...
Shanshan, Cheng, Charles L, Brooks
openaire   +2 more sources

Structures and Dynamics of Dengue Virus Nonstructural Membrane Proteins

Membranes, 2022
Dengue virus is an important human pathogen threating people, especially in tropical and sub-tropical regions. The viral genome has one open reading frame and encodes one polyprotein which can be processed into structural and nonstructural (NS) proteins.
Qingxin Li, Congbao Kang
doaj   +1 more source