Results 81 to 90 of about 540,107 (353)

Heterogeneous Condensation on Simplified Viral Envelope Protein Structures

ACS Applied Materials & Interfaces
Elucidating the mechanisms of heterogeneous condensation on viral and bacterial envelopes is crucial for understanding biothreat transport phenomena and optimizing capture efficiency in condensation-based detection devices. We investigate the impact of viral envelope geometric parameters [e.g., surface structure pitch-to-diameter ratio (p/d)] due to ...
Kawkab Ahasan, Han Hu, Pranav Shrotriya, Todd A. Kingston   +3 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

How simple can a model of an empty viral capsid be? Charge distributions in viral capsids

, 2012
We investigate and quantify salient features of the charge distributions on viral capsids. Our analysis combines the experimentally determined capsid geometry with simple models for ionization of amino acids, thus yielding the detailed description of ...
A Lošdorfer Božič, A Šiber, A Šiber, A Šiber, A Šiber, A Šiber, Antonio Šiber, Anže Lošdorfer Božič, B Michen, CE Felder, CJ Marzec, CL Ting, DG Isom, DG Isom, J Bernal, J Langlet, JD Jackson, K Iwasaki, M Carrillo-Tripp, MR Gunner, P Ni, P Pfeiffer, P Prinsen, R Zandi, R Zandi, Rudolf Podgornik, RV Mannige, S Karlin, T Hu, The UniProt Consortium, TS Baker, VA Belyi, VA Parsegian, VB Chen, W Humphrey, WH Roos, WK Kegel, WK Kegel   +37 more
core   +1 more source

Non-Structural Protein-W61 as a Novel Target in Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV): An In-Vitro and In-Silico Study on Protein-Protein Interactions with Nucleoprotein and Viral Replication [PDF]

, 2023
Ji-Young Park, Chandran Sivasankar, Perumalraja Kirthika, Dhamodharan Prabhu, John Hwa Lee   +4 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Mayaro virus proteins

Memorias do Instituto Oswaldo Cruz, 1993
Mayaro virus was grown in BHK-21 cells and purified by centrifugation in a potassium-tartrate gradient (5-50%). The electron microscopy analyses of the purified virus showed an homogeneous population of enveloped particles with 69 ñ 2.3 nm in diameter ...
J. M. S. Mezencio, M. A. Rebello
doaj   +1 more source

Chiral Quasicrystalline Order and Dodecahedral Geometry in Exceptional Families of Viruses

, 2012
On the example of exceptional families of viruses we i) show the existence of a completely new type of matter organization in nanoparticles, in which the regions with a chiral pentagonal quasicrystalline order of protein positions are arranged in a ...
C. Janot, D. L. Caspar, L. D. Landau, M. Senechal, O. V. Konevtsova, P. G. de Gennes, P. J. Steinhardt, R. Penrose, S. B. Rochal, T. S. Baker, V. L. Lorman   +10 more
core   +5 more sources

Severe Acute Respiratory Syndrome Coronavirus 3a Protein Is a Viral Structural Protein [PDF]

Journal of Virology, 2005
ABSTRACT The present study showed the association of a severe acute respiratory syndrome coronavirus (SCoV) accessory protein, 3a, with plasma membrane and intracellular SCoV particles in infected cells. 3a protein appeared to undergo posttranslational modifications in infected cells and was incorporated into SCoV particles, establishing that
Naoto, Ito, Eric C, Mossel, Krishna, Narayanan, Vsevolod L, Popov, Cheng, Huang, Taisuke, Inoue, Clarence J, Peters, Shinji, Makino   +7 more
openaire   +2 more sources