Results 111 to 120 of about 1,666,541 (346)

Effect of 2 Integrated Interventions on Alcohol Abstinence and Viral Suppression Among Vietnamese Adults With Hazardous Alcohol Use and HIV

JAMA Network Open, 2020
Key Points Question What is the effect of 2 clinic-based behavioral interventions of varying intensity on alcohol use and viral suppression among individuals with HIV and hazardous alcohol use? Findings In this 3-group randomized clinical trial involving
V. Go, H. Hutton, T. V. Ha, G. Chander, C. Latkin, N. V. Mai, B. X. Quynh, Vu Nguyen, T. Sripaipan, K. Lancaster, N. Blackburn, R. Hershow, D. Dowdy, C. Frangakis   +13 more
semanticscholar   +1 more source

Reply: Beyond Viral Suppression

Open Forum Infectious Diseases, 2021
Christoph D Spinner, Eva Wolf, Christoph Boesecke   +2 more
openaire   +2 more sources

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Effectiveness of antiretroviral therapy in the single-tablet regimen era

Revista de Saúde Pública, 2018
OBJECTIVE To evaluate the effectiveness of antiretroviral therapy and the associated factors according to the type of regimen used: Single Tablet Regimen or Multiple Tablet Regimen.
Juliana de Oliveira Costa, Maria das Graças Braga Ceccato, Micheline Rosa Silveira, Palmira de Fátima Bonolo, Edna Afonso Reis, Francisco de Assis Acurcio   +5 more
doaj   +1 more source

Clinic- and individual-level factors that influence HIV viral suppression in adolescents and young adults: a national survey in Kenya.

AIDS (London), 2020
OBJECTIVES To determine clinic- and individual-level correlates of viral suppression among HIV-positive adolescents and young adult (AYA) aged 10-24 years receiving antiretroviral treatment (ART). DESIGN Multi-level cross-sectional analysis using viral
Irene N Njuguna, Jillian Neary, Caren Mburu, D. Black, Kristin M Beima-Sofie, A. Wagner, C. Mugo, Yolanda N. Evans, B. Guthrie, Janet Itindi, A. Onyango, L. Oyiengo, B. Richardson, D. Wamalwa, G. John-Stewart   +14 more
semanticscholar   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Modelling correlates of adolescent and young people viral suppression pathway in Zambia: a Bayesian multi-state approach

Critical Public Health
This study aimed to look into the correlates of viral suppression in HIV-infected adolescents by utilizing Markov renewal multi-state survival models based on the Bayesian Approach, which use a deterministic posterior approximation.
Isaac Fwemba, Samuel Iddi, Yawson Alfred, Chris Guure, Jacques Tamuzi, Peter S. Nyasulu, Samuel Bosomprah   +6 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source