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VirusesThe tropism of the Human Immunodeficiency Virus type 1 (HIV-1) is determined by the use of either or both chemokine coreceptors CCR5 (R5) and CXCR4 (X4) for entry into the target cell.
Angelo Pavesi, Fabio Romerio
doaj +1 more source
Determination of HIV-1 coreceptor tropism using proviral DNA in women before and after viral suppression [PDF]
, 2015 BackgroundAn HIV-1 tropism test is recommended prior to CCR5 antagonist administration to exclude patients harboring non-R5 virus from treatment with this class of antiretrovirals.
Mary Young +21 more
core +1 more source
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
Viral vector tropism for supporting cells in the developing murine cochlea [PDF]
Hearing Research, 2011 Gene-based therapeutics are being developed as novel treatments for genetic hearing loss. One roadblock to effective gene therapy is the identification of vectors which will safely deliver therapeutics to targeted cells. The cellular heterogeneity that exists within the cochlea makes viral tropism a vital consideration for effective inner ear gene ...
Abraham M, Sheffield +6 more
openaire +2 more sources
Viral interferon antagonists and antiviral drugs [PDF]
, 2009 For this project, we developed reporter cell lines that express viral proteins with the potential to be used in cell-based screening assays to select chemical candidates for antiviral drugs.
Nobre, Rita
core +2 more sources
A survey of SARS-CoV-2 tropism
Infectious Diseases & Immunity. The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has significantly burdened global public health.
Xiangxing Jin +4 more
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Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
Altering AAV tropism with mosaic viral capsids
Molecular Therapy, 2005 Over the past decade, AAV-based vectors have emerged as promising candidates for gene therapeutic applications. Despite the broad tropism of the first eight serotypes identified, certain cell types are refractory to transduction with AAV-based vectors. Furthermore, for certain applications the targeting of specific cell types is desirable.
Gigout, L +6 more
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Recent Observations on Australian Bat Lyssavirus Tropism and Viral Entry [PDF]
Viruses, 2014 Australian bat lyssavirus (ABLV) is a recently emerged rhabdovirus of the genus lyssavirus considered endemic in Australian bat populations that causes a neurological disease in people indistinguishable from clinical rabies. There are two distinct variants of ABLV, one that circulates in frugivorous bats (genus Pteropus) and the other in insectivorous ...
Dawn L. Weir +3 more
openaire +3 more sources
Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species. [PDF]
PLoS Pathogens, 2017 The cellular and molecular mechanisms underpinning the unusually high virulence of highly pathogenic avian influenza H5N1 viruses in mammalian species remains unknown.
Smanla Tundup +7 more
doaj +1 more source