Results 1 to 10 of about 2,910 (115)

Vero cell upstream bioprocess development for the production of viral vectors and vaccines

Biotechnology Advances, 2020
The Vero cell line is considered the most used continuous cell line for the production of viral vectors and vaccines. Historically, it is the first cell line that was approved by the WHO for the production of human vaccines. Comprehensive experimental data on the production of many viruses using the Vero cell line can be found in the literature ...
Kiesslich, Sascha, Kamen, Amine A.
openaire   +3 more sources

Ultra scale-down approaches to study the centrifugal harvest for viral vaccine production [PDF]

, 2018
Large scale continuous cell‐line cultures promise greater reproducibility and efficacy for the production of influenza vaccines, and adenovirus for gene therapy.
Altaras, Balvers, Berrill, Boychyn, Boychyn, Boychyn, Chang, Chua, Edelstein., Feng, Garoff, Genzel, Gros, Harrison, Hedlund, Hutchinson, Kasala, Kotterman, Lau, Levy, Lynch, Mannweiler, Maybury, Mclean, Mittereder, Muennig, Murali, Osterhaus, Perlmutter, Pettitt, Rathore, Roberts, Rossman, Russell, Salomon, Schaap, Shaw, Shigematsu, Silva, Skehel, Tait, Titchener-Hooker, Waehler, Wiethoff, Wolff, Xu, Xu, Zaman, Zhang   +48 more
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Industry 4.0 : a vision for personalized medicine supply chains? [PDF]

, 2016
Industry 4.0 foresees a digital transformation of manufacturing resulting in smart factories and supply chains. At the heart of the concept lies the vision of interconnected materials, goods and machines, where goods find their way through the factory ...
Branke, Jürgen, Farid, Suzanne S., Shah, Nilay   +2 more
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Circumventing antivector immunity: potential use of nonhuman adenoviral vectors [PDF]

, 2014
Adenoviruses are efficient gene delivery vectors based on their ability to transduce a wide variety of cell types and drive high-level transient transgene expression. While there have been advances in modifying human adenoviral (HAdV) vectors to increase
Beard C.W., Benkö M., Cauthen A.N., Crawford-Miksza L., Estrella Lopez-Gordo, Gall J., Gall J.G., Gattoni A., Ginsberg H.S., Haviv Y.S., Hofmann C., Iva I. Podgorski, Kajon A.E., Kanerva A., Kass-Eisler A., Kuriyama S., Mastrangeli A., Michou A.I., Nicholas Downes, Ramon Alemany, Rogozhin V.N., Roy S., Seiradake E., Shmarov M.M., Soudais C., Tutykhina I.L., Wang D.Y., Wohlfart C., Ying B., Zakhartchouk A.N., Zeng Q.   +30 more
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Optimization of insect cell based protein production processes - online monitoring, expression systems, scale-up [PDF]

, 2013
Due to the increasing use of insect cell based expression systems in research and industrial recombinant protein production, the development of efficient and reproducible production processes remains a challenging task.
A Axen, A Bluma, A Glindkamp, A Lundstrom, A Negrete, A Tadayyon, A Vilcinskas, A Zeiser, A Zeiser, AP Pearson, AP Pearson, AP Teixeira, AP Teixeira, AP Teixeira, AR Bernard, AR Heath, AW Nienow, BAA Dremel, BH Weigl, C Cannizzaro, C Dyring, C Haake, C Justice, C Justice, C Weber, C Weber, C Weber, C Weber, CA Sellick, CB Elias, CL Davey, CY Li, D Freimark, D Landgrebe, DA Moreno-Habel, DL Jarvis, DL Jarvis, DM Marks, DR O’Reilly, DW Zabriskie, E Petiot, F Altmann, F Anton, FR Schmidt, G Echalier, G Rudolph, G Smagghe, H Suhr, HR Kermis, I Schneider, J Hwang, JA Mackintosh, JG Frerichs, JG Henriques, JK Li, JM Vlak, JP Carvell, JS Guez, JT Vivian, JW Severinghaus, JX Tian, K Joeris, K-D Anders, KA McDonald, KB Konstantinov, L Chu, L Ikonomou, L Maranga, LH Grimm, M Cajlakovic, M Mirzaei, M Rhiel, MMJ Cox, MR Riley, N Uduman, N Wei, N Wei, NR Abu-Absi, O Kohls, P Barrett, P Jeffers, P Roychoudhury, P Wang, R Eibl, R Köneke, R Ulber, R Verma, RG Sparks, RM Kotin, S Ansorge, S Beutel, S Hisiger, S Kawaoka, S Sommerfeld, S-Z Feng, SA Arnold, SP Srinivas, T Hoepfner, T Vicente, TA Bunch, TA Kost, TA Pfeifer, TDC Grace, TE Edmonds, TJ Wickham, V Degouys, V Singh, V Vojinovic, VA Luckow, VA Luckow, W Tan, W Weber, WF Hink, XM Ge, X–X Xu, YT Chung   +115 more
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Cell-Mediated Immune Predictors of Vaccine Effect on Viral Load and CD4 Count in a Phase 2 Therapeutic HIV-1 Vaccine Clinical Trial. [PDF]

, 2017
In a placebo-controlled trial of the peptide-based therapeutic HIV-1 p24 ^Gag vaccine candidate Vacc-4x, participants on combination antiretroviral therapy (cART) received six immunizations over 18weeks, followed by analytical ...
Hovden, A.O., Huang, Y., Pantaleo, G., Pollard, R., Rockstroh, J., Sanchez, B., Sommerfelt, M.A., Tapia, G., Trondsen, M., Zhang, L., Ökvist, M.   +10 more
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Correlative Scanning-Transmission Electron Microscopy Reveals that a Chimeric Flavivirus Is Released as Individual Particles in Secretory Vesicles. [PDF]

, 2014
International audienceThe intracellular morphogenesis of flaviviruses has been well described, but flavivirus release from the host cell remains poorly documented.
Caroline, Sellin, Claude, Lebos, Gaillard, Julien, Jean-Marc, Guillaume, Roingeard, Philippe, Sonia, Georgeault, Uzbekov, Rustem   +6 more
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Emerging technologies for the integration and intensification of downstream bioprocesses [PDF]

, 2013
Downstream processing is currently the major bottleneck for bioproduct generation. In contrast to the advances in fermentation processes, the tools used for downstream processes have struggled to keep pace in the last 20 years. Purification bottlenecks
Aires Barros, M. Raquel, Azevedo, Ana M., Carbajal, Maria Laura, D’Souza, Roy N., Fernandez Lahore, Marcelo, Grasselli, Mariano, Krajnc, Nika Lendero, Kramberger, Petra, Meyer, Ronald   +8 more
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DNA vaccination for prostate cancer: key concepts and considerations [PDF]

, 2015
While locally confined prostate cancer is associated with a low five year mortality rate, advanced or metastatic disease remains a major challenge for healthcare professionals to treat and is usually terminal. As such, there is a need for the development
A Ghosh, A Horwich, A Schietinger, A Thakur, A Yoshida, A-C Durieux, A-K Roos, AB Raff, AC Cunha, AD Frankel, AI Daud, B Ferraro, B Schurko, C. R. UK, CM Fehres, CW Pouton, D Escors, D Yang, D Zhang, DG McNeel, DG McNeel, DM Copolovici, DM Lubaroff, DS Coffey, E Rosenbaum, EF Boudreau, F Eriksson, F Kong, F Saad, G Dom, H Davtyan, H Hosseinkhani, H Lv, H-L Jiang, H-S Jeong, HO McCarthy, HO McCarthy, J Rice, JC Glorioso, JD Wolchok, JL Coll, JM Ottnod, JP Eder, K Oosterhuis, K Zhang, L Chudley, L Fong, LE Johnson, LE Johnson, LE Johnson, M Breunig, M Duvshani-Eshet, M Krupa, M Mahadevan, M Mincheff, M Noguchi, M Pavlenko, M Yoshida, MA Kutzler, MD Brown, MDLL Garcia-Hernandez, ME Martin, MI Milowsky, MT Lin, N Agarwal, N Gao, N Tatsis, NW Kim, NY Sardesai, P Castelo-Branco, PD Gregor, PW Kantoff, PW Kantoff, R Suzuki, R Truant, RA Madan, RB Moss, RB Sims, RS Hubert, S Aggarwal, S Ahmad, S Daya, S Drunen Littel-van den Hurk, S Drunen Littel-van van, S Jones, S Kawakami, S Kim, S Kim, S Mehier-Humbert, S Slovin, S-H Min, S-O Choi, SP Balk, SP Vyas, T Yuan, TJ Graddis, WT Godbey, X Sun, X Zhang, Y Lu, Y Yamashita, Y Yi   +101 more
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Противовирусная активность экстрактов трансгенных растений цикория и салата с геном интерферона α­2b человека [PDF]

, 2012
Изучена биологическая активность белковых экстрактов трансгенных растений Cichorium intybus L. и Lactuca sativa L. с геном интерферона-α2b человека по отношению к вирусу везикулярного стоматита.
Безденежных, Н.А., Кваско, Е.Ю., Кудрявец, Ю.И., Лихова, А.А., Матвеева, Н.А., Шаховский, А.М.   +5 more
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